 | Gérard Depardieu als Christopher Columbus |
 | Armand Assante als Sanchez |
 | Sigourney Weaver als Queen Isabella |
 | Loren Dean als Older Fernando |
 | Ángela Molina als Beatrix |
 | Fernando Rey als Marchena |
 | Michael Wincott als Adrian de Moxica |
 | Kevin Dunn als Captain Mendez |
 | Tchéky Karyo als Martín Alonso Pinzón |
 | Frank Langella als Santangel |
 | Mark Margolis als Bobadilla |
 | Arnold Vosloo als Guevara |
 | Steven Waddington als Bartolome |
 | Fernando Guillén Cuervo als Giacomo |
 | Juan Diego Botto als Diego |
 | Fernando García Rimada als King Ferdinand |
 | Albert Vidal als Hernando de Talavera |
 | José Luis Ferrer als Alonso de Bolaños |
 | Jack Taylor als Vicuna |
 | Billy L. Sullivan als Ten-Year-Old Fernando |
 | John Heffernan als Brother Buyl |
| Ridley Scott | Director |
| Alain Goldman | Producer |
| Ridley Scott | Producer |
| Adrian Biddle | Director of Photography |
| Vangelis | Original Music Composer |
| William M. Anderson | Editor |
| Françoise Bonnot | Editor |
| Armen Minasian | Editor |
| Les Healey | Editor |
| Marc Boyman | Producer |
| Pere Fages | Producer |
| Mimi Polk Gitlin | Executive Producer |
| Iain Smith | Executive Producer |
| Garth Thomas | Producer |
| Louis DiGiaimo | Casting |
| Dan Parada | Casting |
| Deborah Zeitman | Editor |
| Norris Spencer | Production Design |
| Martin Hitchcock | Art Direction |
| Antonio Patón | Art Direction |
| Kevin Phipps | Art Direction |
| Luke Scott | Art Direction |
| Ann Mollo | Set Decoration |
| Charles Knode | Costume Design |
| Barbara Rutter | Costume Design |
| Priscilla John | Casting |
| Benjamín Fernández | Supervising Art Director |
| Leslie Tomkins | Supervising Art Director |
| Luciano Arroyo | Assistant Art Director |
| José Luis del Barco | Assistant Art Director |
| Amado Conejo | Assistant Art Director |
| Tony Rimmington | Assistant Art Director |
| Peter Russell | Assistant Art Director |
| Camilo Lira Colin | Greensman |
| German Ramirez | Greensman |
| Peter Voysey | Sculptor |
| Jim Shields | Supervising Sound Editor |
| Kent Houston | Visual Effects Supervisor |
| Greg Powell | Stunt Coordinator |
| David Appleby | Still Photographer |
| Francesc Brualla | Gaffer |
| Kevin Day | Gaffer |
| Martin Kenzie | Camera Operator |
| David Worley | Camera Operator |
| Guillermo Cano | Script Supervisor |
| Mark Albela | Location Manager |
| Juan Carlos Caro | Location Manager |
| Kevin De La Noy | Location Manager |
| Luca Kouimelis | Script Supervisor |
| Gina McShane | Chef |
| Luis Puig | Chef |
| Eduardo Santana | Location Manager |
| John Whelan | Chef |
| Robin Clarke | Music Editor |
| Sergio Miranda | Associate Producer |
| Pablo Espinosa | Wardrobe Assistant |
| Roselyne Bosch | Producer |
| Elaine Bowerbank | Hairstylist |
| Eithné Fennel | Hairstylist |
| Paula Gillespie | Hairstylist |
| Paquita Núñez | Hairstylist |
| Dolores Sánchez | Hairstylist |
| Lisa Tomblin | Hairstylist |
| Geraldine Jones | Hairstylist |
| María del Carmen Clavel | Makeup Artist |
| José Luis Pérez | Makeup Artist |
| José Antonio Sánchez | Makeup Artist |
| Susana Sánchez | Makeup Artist |
| Linda DeVetta | Makeup Artist |
| Tony Graysmark | Construction Manager |
| Ramón Moya | Construction Manager |
| Stephen Dobric | Draughtsman |
| Jonathan McKinstry | Draughtsman |
| Gary Tomkins | Draughtsman |
| Robert Zammit-Pace | Draughtsman |
| Honorio Cruz | Dressing Prop |
| Luis Muñoz | Dressing Prop |
| John Palmer | Dressing Prop |
| Bradley Torbett | Dressing Prop |
| Keith Vowles | Dressing Prop |
| Jake Wells | Dressing Prop |
| Andrew Palmer | Dressing Prop |
| John Davey | Painter |
| Graeme Thompson | Scenic Artist |
| Julian Martin Benito | Scenic Artist |
| Jesus Canveras | Standby Carpenter |
| Santos Pedroche | Standby Carpenter |
| Pedro Calderón | Standby Painter |
| Sherman Labby | Storyboard Artist |
| Bob Smith | Camera Operator |
| Kevin Greene | Camera Technician |
| Thomas Guard | Camera Trainee |
| Manuel Andujar | Electrician |
| Marcelo Correa Sanchez | Electrician |
| Jaime Domenech | Electrician |
| Miguel González | Electrician |
| Juan Fernando Guzmán | Electrician |
| Jordi Joaní | Electrician |
| Josep Llopart | Electrician |
| Alejandro Martín | Electrician |
| José María Martín | Electrician |
| John Modder | Electrician |
| Stewart Monteith | Electrician |
| Antonio Pascual | Electrician |
| Ricky Pattenden | Electrician |
| Jesús Pelegrín | Electrician |
| Emilio Samper | Electrician |
| Steve Burgess | Focus Puller |
| Fraser Taggart | Focus Puller |
| Eamonn O'Keeffe | Focus Puller |
| Don Maton | Generator Operator |
| Ken Sheppard | Generator Operator |
| Eddie Knight | Rigging Gaffer |
| Ann Taylor | Assistant Costume Designer |
| Anthony Brookman | Costume Assistant |
| Bina Daigeler | Costume Assistant |
| Pablo Espinosa | Costume Assistant |
| Isabel Perales | Costume Assistant |
| Ángeles del Saz | Costume Assistant |
| Peter Edmonds | Costumer |
| Andrés Fernández | Costumer |
| Agustín Jiménez | Costumer |
| Penny McVitie | Seamstress |
| Stewart Meachem | Wardrobe Master |
| Janek Sirrs | Visual Effects |
| Domicio Melero | Animal Wrangler |
| Juan Cruz Mesa | Animal Wrangler |
| Simon Atherton | Armorer |
| Trilby Norton | Production Coordinator |
| Joyce Turner | Production Coordinator |
| Belinda Uriegas | Production Coordinator |
| Mario Sotela | Production Executive |
| José Luis Escolar | Production Manager |
| Sean Clayton | Production Runner |
| Maralyn Causley | Production Secretary |
| Joelle Delaney | Production Secretary |
| Patrick Clayton | Production Supervisor |
| José Antonio Pérez Giner | Production Supervisor |
| Terry Needham | First Assistant Director |
| Kevin De La Noy | First Assistant Director |
| Jacqueline Fouchet | Assistant Editor |
| Julian Rodd | Assistant Editor |
| Steve Spencer | Assistant Editor |
| Tony Tromp | Assistant Editor |
| Kevin Daley | Negative Cutter |
| Pat Gilbert | Assistant Sound Editor |
| Michael Monks | Assistant Sound Editor |
| Patrick Brennan | Assistant Sound Editor |
| Robert Mullen | Assistant Sound Editor |
| Bernard Chaumeil | Boom Operator |
| Pierre Gamet | Sound |
| Hector Viquez Barth | Sound Assistant |
| Peter Best | Sound Editor |
| Derek Holding | Sound Editor |
| Rocky Phelan | Sound Editor |
| Robert Risk | Sound Editor |
| John Hayward | Sound Recordist |
| Charles Torbett | Property Master |
| Ron Davis | Sound Editor |
| Roselyne Bosch | Screenplay |
| Roselyne Bosch | Story |
| Terry Wells Sr. | Property Master |
| Hugh Johnson | Second Unit Director of Photography |
| Gary Powell | Stunts |
| Greg Powell | Animal Coordinator |
