 | Katherine Heigl als Jane Nichols |
 | James Marsden als Kevin Doyle |
 | Malin Åkerman als Tess Nichols |
 | Judy Greer als Casey |
 | Edward Burns als George |
 | Melora Hardin als Maureen |
 | Brian Kerwin als Hal Nichols |
 | Maulik Pancholy als Trent |
 | David Castro als Pedro |
 | Krysten Ritter als Gina the Goth |
 | Michael Ziegfeld als Taxi Fahrer Khaleel |
 | Jennifer Lim als Bridal Salesgirl |
 | Danielle Skraastad als Bride Suzanne |
 | Yetta Gottesman als Hip Bridesmaid |
 | Erin Fogel als Shari Rabinowitz |
 | Bern Cohen als Rabbi |
| Brigitte Bourdeau als Salesgirl Olga |
 | Peyton List als Young Jane |
| Charli Barcena als Young Tess |
 | Jane Pfitsch als Cousin Lisa |
| Laksh Singh als Hindu Priest |
| Lyralen Kaye als Yoga Instructor |
 | Ronald Guttman als Antoine |
 | Ron Simons als Boathouse Chef |
 | Robert Clohessy als Dive Bartender |
 | Michael Mosley als Bar Dude |
| Alyssa Bresnahan als Diner Waitress |
| Ellen H. Schwartz als Diner Waitress |
 | Jennifer Bassey als Jane's Aunt |
 | Alexa Havins als Boat Bride |
| Richard O'Rourke als Jane's Minister |
 | Kathryn Weisbeck als Tara Bride (uncredited) |
| Robert F. Newmyer | Executive Producer |
| Michael Mayer | Executive Producer |
| Becki Cross Trujillo | Executive Producer |
| Peter James | Director of Photography |
| Anne Fletcher | Director |
| Roger Birnbaum | Producer |
| Jonathan Glickman | Producer |
| Erin Stam | Executive Producer |
| Gary Barber | Producer |
| Catherine Marie Thomas | Costume Design |
| Priscilla Nedd-Friendly | Editor |
| Steven Feinberg | Thanks |
| Zachary Woodlee | Choreographer |
| Ray Fisher | Leadman |
| Anthony Veader | Hair Department Head |
| Jonathan Arkin | Art Direction |
| Miguel López-Castillo | Art Direction |
| Joseph Kearney | Construction Coordinator |
| Frank Graziadei | Boom Operator |
| Susanna David | Script Supervisor |
| Kate Bulpitt | Casting Associate |
| Steven Ritzi | Stunt Coordinator |
| Michael Atwell | Construction Foreman |
| Chryss Hionis | Set Decoration |
| Jason Mayoh | Art Department Coordinator |
| Deborah Newhall | Costume Supervisor |
| Steph Accetta | Unit Production Manager |
| Karen Baker Landers | Supervising Sound Editor |
| Peter Oillataguerre | Executive In Charge Of Production |
| Christopher Assells | Sound Effects Editor |
| Shepherd Frankel | Production Design |
| Jon Taylor | Sound Re-Recording Mixer |
| Christian P. Minkler | Sound Re-Recording Mixer |
| Amanda Mackey | Casting |
| Paulina Kuszta | Visual Effects Coordinator |
| Michele Ferrone | Visual Effects Producer |
| Cathy Sandrich Gelfond | Casting |
| Linda Grimes | Makeup Department Head |
| Charles Martin Inouye | Music Editor |
| Adam McCarthy | Location Manager |
| Aline Brosh McKenna | Writer |
| Buck Damon | Music Supervisor |
| Adam McCarthy | Production Supervisor |
| Jocelyn Thomas | Casting Associate |
| Amanda Goodpaster | Music Editor |
| Barry Wetcher | Still Photographer |
| Tom Nelson | Production Sound Mixer |
| Mark Dornfeld | Visual Effects Supervisor |
| Zoë Bell | Stunts |
| Frederick H. Stahly | Dialogue Editor |
| Ann Miller | Property Master |
| Chris Jargo | ADR Supervisor |
| Jeffrey Wilhoit | Foley Artist |
| Dean St. John | ADR Mixer |
| Nerses Gezalyan | Foley Mixer |
| Julie Altus | ADR Recordist |
| Randy Edelman | Original Music Composer |
| James Moriana | Foley Artist |
| Adam Cole | Post Production Coordinator |
| Caroline Duncan | Assistant Costume Designer |
| G. A. Aguilar | Stunts |
| Aja Frary | Stunts |
| Aaron Vexler | Stunt Double |
| Terence Lorino | Stunts |
| Blaise Corrigan | Stunts |
| Jodi Michelle Pynn | Stunts |
| Wade Allen | Stunts |
| Joe Mancini | Stunt Driver |
