 | Russell Crowe als John Nash |
 | Jennifer Connelly als Alicia Nash |
 | Ed Harris als William Parcher |
 | Paul Bettany als Charles Herman |
 | Christopher Plummer als Dr. Rosen |
 | Josh Lucas als Martin Hansen |
 | Adam Goldberg als Richard Sol |
 | Anthony Rapp als Bender |
 | Judd Hirsch als Helinger |
 | Jason Gray-Stanford als Ainsley Neilson |
 | Austin Pendleton als Thomas King |
 | Vivien Cardone als Marcee |
| Jillie Simon als Bar Co-Ed |
| Victor Steinbach als Prof. Horner |
 | Tanya Clarke als Becky |
| Thomas F. Walsh als Captain |
| Jesse Doran als General |
| Kent Cassella als Analyst |
| Patrick Blindauer als MIT Student |
| John Blaylock als Photographer |
 | Roy Thinnes als Governor |
| Anthony Easton als Young Man |
 | Cheryl Howard als Harvard Administrator |
 | Josh Pais als Princeton Professor |
| David B. Allen als John Nash Teenager |
 | Michael Esper als John Nash Young Man |
 | Erik Van Wyck als Princeton Student |
 | Rance Howard als White-Haired Patient |
 | Jane Jenkins als Code-Red Nurse |
| Darius Stone als Adjunct |
| Valentina Cardinalli als Joyce |
 | Teagle F. Bougere als Young Professor |
| Amy Walz als Blond in Bar |
| Tracey Toomey als Brunette |
| Jennifer Weedon als Brunette |
| Yvonne Thomas als Brunette |
| Holly Pitrago als Brunette |
| Isadore Rosenfeld als Pen Ceremony Professor |
| Tom McNutt als Pen Ceremony Professor |
| Alex Toma als Toby |
 | Bryce Dallas Howard als Student at Harvard University (Uncredited) |
 | Ryan O'Connor als Princeton Student (uncredited) |
| Kathleen McGill | Producer |
| Louisa Velis | Executive Producer |
| Roger Deakins | Director of Photography |
| Mike Hill | Editor |
| Maureen Peyrot | Producer |
| Jane Jenkins | Casting |
| Robert Guerra | Art Direction |
| Karen Kehela Sherwood | Executive Producer |
| Daniel P. Hanley | Editor |
| James Horner | Original Music Composer |
| Ron Howard | Director |
| Todd Hallowell | Executive Producer |
| Janet Hirshenson | Casting |
| Rita Ryack | Costume Design |
| Ron Howard | Producer |
| Aldric La'Auli Porter | Executive Producer |
| Leslie E. Rollins | Set Decoration |
| Brian Grazer | Producer |
| Winsome G. McKoy | Costume Supervisor |
| William A. Campbell | Costume Supervisor |
| Kevin Draves | Costume Supervisor |
| Wynn Thomas | Production Design |
| Jim Henrikson | Music Editor |
| Julie Kuehndorf | Unit Publicist |
| Joseph Grimaldi | Best Boy Electric |
| Bradley Mayer | Assistant Art Director |
| Harry Peck Bolles | Sound Effects Editor |
| Wilfred Caban | Special Effects Coordinator |
| Kyle Rudolph | Camera Operator |
| Gerardo Puglia | Camera Operator |
| Martin Bernstein | Construction Coordinator |
| Judy Dickerson | Dialect Coach |
| Chris Jenkins | Sound Re-Recording Mixer |
| Kevin Scott Mack | Visual Effects Supervisor |
| Steve Castellano | Post Production Supervisor |
| Peter Bucossi | Stunt Coordinator |
| Eytan Mirsky | Sound Effects Editor |
| Heather J. Morrison | Visual Effects Editor |
| Eva Z. Cabrera | Script Supervisor |
| Lyn Pinezich | Location Manager |
| Kelly L'Estrange | Visual Effects Producer |
| Nancy Winters | Assistant Art Director |
| Frank A. Montaño | Sound Re-Recording Mixer |
| Bill O'Leary | Gaffer |
| Anthony J. Ciccolini III | Supervising Sound Editor |
| Daniel Pagan | Sound Effects Editor |
| Joseph Proscia | Leadman |
| Eli Reed | Still Photographer |
| Deborah Wallach | ADR Supervisor |
| Tommy Allen | Property Master |
| Todd Hallowell | Second Unit Director |
| Aldric La'Auli Porter | First Assistant Director |
| Allan Byer | Production Sound Mixer |
| Stan Bochner | Dialogue Editor |
| Marc Laub | Dialogue Editor |
| Patrick Dundas | Foley Editor |
| Missy Cohen | Foley Editor |
| Louis Cerborino | Dialogue Editor |
| Bob Olari | Sound Recordist |
| Greg Cannom | Special Effects Makeup Artist |
| Peter Walts | Best Boy Electric |
| Jonathan Nussbaum | Best Boy Grip |
| Rick Marroquin | Dolly Grip |
| Douglas Murray | ADR Recordist |
| Katie Nook | Digital Compositor |
| Dale Brownell | Hairstylist |
| Tim Norman | First Assistant Camera |
| Krista Benson | Digital Compositor |
| James Boniece | Key Rigging Grip |
| Bill Dance | Extras Casting |
| Paul Weathered | Property Master |
| Don Peebles | Assistant Sound Editor |
| Nikos Kalaitzidis | 3D Animator |
| Charlie Marroquin | Best Boy Grip |
| Bruce Hamme | Dolly Grip |
| Kristen McTigue | Casting Assistant |
| Michael Thompson | ADR Mixer |
| Antoinette Carr | Key Hair Stylist |
| Howard Davidson | Rigging Grip |
| Kevin Brainerd | Assistant Costume Designer |
| Betsy Klompus | Assistant Property Master |
| Dennis Eger | Key Makeup Artist |
| Andy Harris | First Assistant Camera |
| Richie Ford | Rigging Gaffer |
| Peter White | Costumer |
| Lisa Barnstone | Scenic Artist |
| Paul J. Zydel | ADR Mixer |
| Nancy Cabrera | Foley Artist |
| Jessica Harris | Digital Compositor |
| Neal Martz | Makeup Department Head |
| Laurie Buehler | Seamstress |
| Suzy Mazzarese-Allison | Hairstylist |
| Linda Lazar | Makeup Artist |
| Kenneth Fundus | Dolly Grip |
| Patrick Quinn | Second Assistant Camera |
| Christine Moosher | Assistant Set Decoration |
| Warren Drummond | Storyboard Artist |
| Dean Drabin | ADR Mixer |
| Gimo Chanphianamvong | Digital Compositor |
| David M. Dunlap | Second Unit Director of Photography |
| Mary Jo 'MJ' McGrath | Wardrobe Assistant |
| Ann Edgeworth | Assistant Property Master |
| Keith Huggins | 3D Animator |
| Eliot Sirota | 3D Modeller |
| Sal Lanza | Key Grip |
| Marcia Oste | Costume Supervisor |
| Gabriel Goodenough | Camera Loader |
| Perri Wainwright | Digital Compositor |
| Greg Addison | Gaffer |
| Lynne Twentyman | Script Supervisor |
| Claas Henke | Compositing Supervisor |
| Colleen Callaghan | Key Hair Stylist |
| Todd Kleitsch | Key Makeup Artist |
| Ginger Geary | Foley Artist |
| Matthew E. Butler | Digital Effects Supervisor |
| Paul Abatemarco | Visual Effects Coordinator |
| James R. Belletier | First Assistant Camera |
| Kris Enos | Second Assistant Camera |
| Thomas R. Dickens | 3D Modeller |
| Kymbra Callaghan | Makeup Artist |
| Brick Mason | Storyboard Artist |
| Claudia Carle | ADR Recordist |
| Livia Ruzic | ADR Recordist |
| Mitchell Andrew Lillian | Key Grip |
| Todd S. Klein | Rigging Grip |
| Anthony Starbuck | Sound Mixer |
| Michelle Macirella | Production Secretary |
| Audra Polk | Production Secretary |
| Guy Barresi | Assistant Editor |
| Richard Friedlander | First Assistant Editor |
| Mike Milliken | Color Timer |
| Judy Pursley | First Assistant Accountant |
| Glenn Allen | Assistant Editor |
| Evan Perazzo | Location Manager |
| Tamara Bally | Production Accountant |
| Gary Burritt | Negative Cutter |
| David Bausch | Production Coordinator |
| Brandon McNaughton | Digital Compositor |
| Gary Archer | Prosthetics |
| Sylvia Nasar | Book |
| Akiva Goldsman | Writer |
| Brian Smyj | Stunts |
