 | Michael Stuhlbarg als Larry Gopnik |
 | Richard Kind als Uncle Arthur |
 | Fred Melamed als Sy Ableman |
 | Sari Lennick als Judith Gopnik |
 | Aaron Wolff als Danny Gopnik |
 | Jessica McManus als Sarah Gopnik |
 | Peter Breitmayer als Mr. Brandt |
| Brent Braunschweig als Mitch Brandt |
| David Kang als Clive Park |
| Benjamin Portnoe als Danny's Reefer Buddy |
| Jack Swiler als Boy on Bus |
| Andrew S. Lentz als Cursing Boy on Bus |
| Jon Kaminski Jr. als Mike Fagle |
 | Ari Hoptman als Arlen Finkle |
 | Alan Mandell als Rabbi Marshak |
 | Amy Landecker als Mrs. Samsky |
 | George Wyner als Rabbi Nachtner |
 | Michael Tezla als Dr. Sussman |
 | Katherine Borowitz als Friend at the Picnic |
 | Steve Park als Clive's Father |
 | Allen Lewis Rickman als Shtetl Husband |
 | Yelena Shmulenson als Shtetl Wife |
 | Fyvush Finkel als Dybbuk? |
| Ronald Schultz als Hebrew School Teacher |
 | Raye Birk als Dr. Shapiro |
 | Jane Hammill als Larry's Secretary |
| Claudia Wilkens als Marshak's Secretary |
 | Simon Helberg als Rabbi Scott |
 | Adam Arkin als Divorce Lawyer |
| James Cada als Cop #1 |
 | Michael Lerner als Solomon Schlutz |
 | Charles Brin als Hebrew School Principal |
| Michael Engel als Torah Blesser |
 | Tyson Bidner als Magbiah |
| Phyllis Harris als Hebrew School Tea Lady |
| Piper Sigel-Bruse als D'vorah |
| Hannah Nemer als Sarah's Friend |
| Rita Vassallo als Law Firm Secretary |
| Warren Keith als Dick Dutton (voice) |
| Neil Newman als Cantor |
 | Tim Russell als Detective #1 |
| Jim Lichtscheidl als Detective #2 |
| Wayne A. Evenson als Russell Krauss |
 | Scott Thompson Baker als Sci-Fi Movie Hero |
| Landyn Banx als Physics Student (uncredited) |
 | Punnavith Koy als Physics Nerd (uncredited) |
| Joel Thingvall als Physics Student (uncredited) |
 | Amanda Day als Physics Student (uncredited) |
| Joel Coen | Editor |
| Joel Coen | Producer |
| Eric Fellner | Executive Producer |
| Tim Bevan | Executive Producer |
| Ellen Chenoweth | Casting |
| Rachel Tenner | Casting |
| Joel Coen | Director |
| Jess Gonchor | Production Design |
| Robert Graf | Executive Producer |
| Joel Coen | Writer |
| Ethan Coen | Editor |
| Roger Deakins | Director of Photography |
| Carter Burwell | Original Music Composer |
| Ethan Coen | Director |
| Ethan Coen | Writer |
| Ethan Coen | Producer |
| Deborah Jensen | Art Direction |
| Thomas Johnston | Script Supervisor |
| Jenny Eagan | Assistant Costume Designer |
| Greg Orloff | Sound Re-Recording Mixer |
| Jean Ann Black | Makeup Department Head |
| Peter F. Kurland | Sound mixer |
| Karen Ruth Getchell | Production Supervisor |
| Wilson Webb | Still Photographer |
| Nancy Haigh | Set Decoration |
| Skip Lievsay | Sound Re-Recording Mixer |
| Craig Berkey | Sound Designer |
| Jarrette Moats | Art Department Coordinator |
| Larz Anderson | Special Effects Coordinator |
| Mary Zophres | Costume Design |
| Fríða Aradóttir | Hair Department Head |
| Craig Berkey | Sound Re-Recording Mixer |
| Skip Lievsay | Supervising Sound Editor |
| Jery Hewitt | Stunt Coordinator |
| James Morioka | Dialogue Editor |
| Byron Wilson | Dialogue Editor |
| Robert Graf | Unit Production Manager |
| Betsy Magruder | First Assistant Director |
| Bac DeLorme | Second Assistant Director |
| Danny Downey | Stunts |
| Eric D. Howell | Stunts |
| Cheryl Kurk | Production Accountant |
| Catherine Farrell | Post Production Supervisor |
| Roger Deakins | Camera Operator |
| Andy Harris | First Assistant Camera |
| Michael Lindquist | Second Assistant Camera |
| Cole Koehler | Camera Loader |
| Maria Juranic | Camera Production Assistant |
| Matt Olson | Camera Production Assistant |
| Katie McQuerrey | Associate Editor |
| Emma Gaffney | First Assistant Editor |
| Jeff Schoen | Assistant Art Director |
| Maria Baker | Set Designer |
| Gregory Hill | Graphic Designer |
| Scott Troha | Dresser |
| Scott Nordhausen | On Set Dresser |
| Matt Joyer | Swing |
| Sarah Kruchowski | Swing |
| Quentin Matthys | Swing |
| Brian J. Simpson | Swing |
| Ryan Tallant | Swing |
| Chris Thickins | Swing |
| Rob Walstead | Swing |
| Cate Honzl | Art Department Production Assistant |
| Keith Walters | Property Master |
| John C. Cameron | Assistant Property Master |
| Randall L. Johnson | Boom Operator |
| Chris C. Benson | Utility Sound |
| Peter Zimbicki | Utility Sound |
| Bill O'Leary | Chief Lighting Technician |
| Joseph Grimaldi | Best Boy Electric |
| Tom Franchett | Rigging Gaffer |
| Edward Cohen | Electrician |
| Craig Hanson | Electrician |
| Travis Hottinger | Electrician |
| Kevin Karpinski | Electrician |
| Jeff Villars | Electrician |
| Mitchell Andrew Lillian | Key Grip |
| Paul Candrilli | Best Boy Grip |
| Bruce Hamme | Dolly Grip |
| Peter Clemence | Key Rigging Grip |
| Joseph Gallup | Grip |
| Scott Jolstad | Grip |
| David Pope | Grip |
| Darin Spring | Grip |
| Tristan Allen | Rigging Grip |
| James Farrell | Rigging Grip |
| Peter Von Grossman | Rigging Grip |
| Virginia Burton | Costume Supervisor |
| Lori DeLapp | Costume Supervisor |
| Jane E. Williams | Key Costumer |
| Nikki Fallenstein | Set Costumer |
| Melissa Seitzer | Set Costumer |
| Cerah Tymoshuk | Costume Assistant |
| Joan Lee | Costume Assistant |
| Mary Flaa | Makeup Department Head |
| Carrie Messina | Assistant Makeup Artist |
| Christien Tinsley | Makeup Effects |
| Dianna Rochelle Johnson | Assistant Hairstylist |
| Rachael Lin Gallaghan | Production Coordinator |
| Kris Barberg | Assistant Production Coordinator |
| Terrence B. Zinn | Second Second Assistant Director |
| Tyson Bidner | Location Manager |
| Anne Healy | Assistant Location Manager |
| Kat Donahue | Assistant Location Manager |
| Chris Cloud | Location Assistant |
| Mark Har | Location Scout |
| Amelia Rasche McCarthy | Casting Associate |
| Debbie DeLisi | Extras Casting |
| Kati Batchelder | Extras Casting Assistant |
| Aaron Greenwood | Extras Casting Assistant |
| Todd Kasow | Music Editor |
| Kenton Jakub | ADR Editor |
| Joel Dougherty | Foley Editor |
| Phil Barrie | First Assistant Sound Editor |
| Johnna Chism | Assistant Sound Editor |
| George A. Lara | Foley Mixer |
| Marko Costanzo | Foley Artist |
| Timothy O'Toole | Video Assist Operator |
| Payam Shohadai | Executive Visual Effects Producer |
| Vincent Cirelli | Visual Effects Supervisor |
| Steven Swanson | Visual Effects Producer |
| Steve Griffith | Visual Effects Producer |
| Justin Johnson | Digital Effects Supervisor |
| Oliver Arnold | CG Supervisor |
| Katie Godwin | Visual Effects Coordinator |
| Alexandre Cancado | Compositor |
| Jared Simeth | Compositor |
| Joey Sila | Compositor |
| James Waterson | Compositor |
| Randall Balsmeyer | Title Designer |
