 | Griffin Dunne als Paul Hackett |
 | Rosanna Arquette als Marcy |
 | Linda Fiorentino als Kiki |
 | Teri Garr als Julie |
 | John Heard als Tom the Bartender |
 | Tommy Chong als Pepe |
 | Cheech Marin als Neil |
 | Catherine O'Hara als Gail |
 | Will Patton als Horst |
 | Verna Bloom als June |
 | Bronson Pinchot als Lloyd |
 | Robert Plunket als Street Pickup |
 | Rocco Sisto als Coffee Shop Cashier |
 | Larry Block als Taxi Driver |
 | Dick Miller als Waiter |
 | Victor Argo als Diner Cashier |
 | Murray Moston als Subway Attendant |
| John P. Codiglia als Transit Cop |
| Clarke Evans als Neighbor #1 |
| Victor Bumbalo als Neighbor #2 |
| Bill Elverman als Neighbor #3 |
| Joel Jason als Biker #1 |
| Rand Carr als Biker #2 |
 | Clarence Felder als Bouncer |
 | Henry Judd Baker als Jett |
| Margo Winkler als Woman With Gun |
| Victor Magnotta als Dead Man |
 | Robin Johnson als Punk Girl |
| Stephen Lim als Club Berlin Bartender |
 | Frank Aquilino als Angry Mob Member |
| Maree Catalano als Angry Mob Member |
| Paula Raflo als Angry Mob Member |
 | Rockets Redglare als Angry Mob Member |
 | Charles Scorsese als Club Berlin Patron (uncredited) |
 | Martin Scorsese als Club Berlin Searchlight Operator (uncredited) |
| John Spacely als Club Berlin Patron with Eyepatch (uncredited) |
| Thelma Schoonmaker | Editor |
| Martin Scorsese | Director |
| Howard Shore | Original Music Composer |
| Robert F. Colesberry | Producer |
| Michael Ballhaus | Director of Photography |
| Griffin Dunne | Producer |
| Amy Robinson | Producer |
| Joseph Minion | Writer |
| Jeffrey Townsend | Production Design |
| Leslie A. Pope | Set Decoration |
| Mary Colquhoun | Casting |
| Deborah Schindler | Associate Producer |
| Stephen J. Lineweaver | Art Direction |
| Rita Ryack | Costume Design |
| Skip Lievsay | Supervising Sound Editor |
| Tom Fleischman | Sound Re-Recording Mixer |
| Dan Perri | Title Designer |
| Medusah | Hairstylist |
| Valli O'Reilly | Makeup Artist |
| Michael Jacobi | Sound Editor |
| Neil L. Kaufman | Sound Editor |
| Magdaline Volaitis | Sound Editor |
| Marko Costanzo | Foley Artist |
| Louis Bertini | Assistant Sound Editor |
| Keith Gardner | Boom Operator |
| Chat Gunter | Sound Mixer |
| Marissa Littlefield | Assistant Sound Editor |
| Barbara Minor | Assistant Sound Editor |
| Dick Vorisek | Sound Re-Recording Mixer |
| Charles Scorsese | Wardrobe Assistant |
| Sarah M. Brim | Second Assistant Director |
| Stephen Lim | First Assistant Director |
| Christopher Griffin | Second Assistant Director |
| David H. Allen | Set Dresser |
| Leigh Kyle | Assistant Art Director |
| Jordan H. Fischer | Stunts |
| Harry Madsen | Stunt Coordinator |
| Florian Ballhaus | Second Assistant Camera |
| Jan Sebastian Ballhaus | Second Assistant Camera |
| Stefan Czapsky | Gaffer |
| Arthur Blum | Key Grip |
| David M. Dunlap | First Assistant Camera |
| Anthony Dunne | Grip |
| Charlie Marroquin | Grip |
| Larry McConkey | Steadicam Operator |
| Susan Starr | Second Assistant Camera |
