 | Klaus Kinski als Don Lope de Aguirre |
 | Helena Rojo als Inés de Atienza |
 | Del Negro als Brother Gaspar de Carvajal |
 | Ruy Guerra als Don Pedro de Ursúa |
 | Peter Berling als Don Fernando de Guzmán |
 | Cecilia Rivera als Flores, Aguirre's Daughter |
 | Daniel Ades als Perucho |
 | Edward Roland als Okello |
| Alexandra Cheves |
| Armando Polanah als Armando |
| Daniel Farfán |
| Julio E. Martínez |
| Alejandro Repullés als Gonzalo Pizarro |
 | Claus Biederstaedt als Brother Gaspar de Carvajal (voice) (uncredited) |
| Lothar Blumhagen als Don Pedro de Ursúa (voice) (uncredited) |
| Heinz Theo Branding als Don Fernando de Guzmán (voice) (uncredited) |
 | Christian Brückner als Balthasar (voice) (uncredited) |
| Michael Chevalier als Conqueror Being Beheaded (voice) (uncredited) |
| Norbert Gescher als Conqueror (voice) (uncredited) |
| Justo González als González (uncredited) |
| Uta Hallant als Inés / Flores (voice) (uncredited) |
 | Manfred Lehmann als Conqueror (voice) (uncredited) |
| Antonio Marquez als (uncredited) |
| Gerd Martienzen als Don Lope de Aguirre (voice) (uncredited) |
| Edgar Ott als Gonzalo Pizarro (voice) (uncredited) |
| Uwe Paulsen als Okello (voice) (uncredited) |
| Dieter Ranspach als Perucho (voice) (uncredited) |
| Werner Herzog | Director |
| Werner Herzog | Producer |
| Popol Vuh | Original Music Composer |
| Thomas Mauch | Director of Photography |
| Beate Mainka-Jellinghaus | Editor |
| Herbert Prasch | Sound Designer |
| Hans Prescher | Producer |
| Werner Herzog | Writer |
| Bob Oliver | Sound Recordist |
| Gustavo Cerff Arbulú | Assistant Director |
| Ovidio Ore | Camera Operator |
| Francisco Joán | Second Unit Cinematographer |
| Orlando Macchiavello | Second Unit Cinematographer |
| Daniel Camino | Co-Producer |
| Lucki Stipetić | Line Producer |
| Gustavo Cerff Arbulú | Location Manager |
| Walter Saxer | Production Manager |
| Lucki Stipetić | Production Manager |
| Wolf Stipetić | Production Manager |
| Georg Hagmüller | Production Assistant |
| Ina Fritsche | Production Assistant |
| René Lechleitner | Production Assistant |
| Martje Grohmann | Production Assistant |
| Juvenal Herrera | Special Effects |
| Miguel Vázquez | Special Effects |
