 | Tom Cruise als Barry Seal |
 | Sarah Wright als Lucy Seal |
 | Domhnall Gleeson als Monty Schafer |
 | Alejandro Edda als Jorge Ochoa |
 | Jesse Plemons als Sheriff Downing |
 | Connor Trinneer als George W. Bush |
 | Mauricio Mejía als Pablo Escobar |
 | Jayma Mays als Dana Sibota |
 | Lola Kirke als Judy Downing |
 | April Billingsley als Jenny |
 | Jayson Warner Smith als Bill Cooper |
 | William Mark McCullough als Pete Dubois |
 | Lara Grice als Female Reporter (uncredited) |
 | Frank Licari als ATF Special Agent Franks |
 | Jed Rees als Louis Finkle |
 | Caleb Landry Jones als JB |
 | Benito Martinez als James Rangel |
 | Justice Leak als Agent Winter |
 | Sharon Conley als DEA Agent Grace (uncredited) |
 | Mike Pniewski als Willie |
 | Robert Pralgo als Gary |
 | E. Roger Mitchell als Agent Craig McCall |
 | Morgan Hinkleman als Christina Seal |
 | Courtney Lakin als Stewardess |
 | Chris Gann als Donor #2 (uncredited) |
 | Fredy Yate als Carlos Lehder |
 | Robert Farrior als Oliver North |
 | Alberto Ospino als Manuel Noriega |
| Felipe Bernedette als Translator |
 | Daniel Lugo als Adolfo Calero |
 | Lauren Boyd als Secretary |
 | Nancy Reagan als Herself (archive footage) |
 | Lauren Revard als Teller |
 | Marcus Hester als Parka |
 | Alex Collins als ATF #1 |
 | Scott Poythress als ATF #2 |
 | Alpha Trivette als Judge Linkletter |
 | Kevin L. Johnson als Agent Horace Wainwright |
| DeVere Jehl als Plain Clothed Man |
| Emilio Sierra als Héctor (Colombian Driver) |
 | Leon Lamar als Elderly Man |
 | Maria Howell als NSC Woman |
 | Darla Delgado als Customs Agent |
 | Mickey Sumner als North's Aide Fawn Hall |
 | Daniel Thomas May als CIA Man |
 | Chloe Swan Sparwath als LeAnn |
| Alex Quarles als Aaron |
| Trip McCarthy als Dean |
| Zachary Powell als Dean |
 | Jairo Ordóñez als Scar |
 | Matt Mercurio als FBI Analyst |
 | Johnny Otto als Protester |
 | Ronald Reagan als Himself (archive footage) |
 | Kayla Perkins als Waitress (uncredited) |
| Michael Mercaldi als Sandinista (uncredited) |
 | Dan Southworth als Agent Winters (uncredited) |
| Bill Billions als Radar Op. #1 (uncredited) |
| Doug Liman | Director |
| Gary Spinelli | Writer |
| César Charlone | Director of Photography |
| Ray Angelic | Producer |
| Doug Davison | Producer |
| Brian Grazer | Producer |
| Brian Oliver | Producer |
| Kim Roth | Producer |
| Tyler Thompson | Producer |
| Mindy Marin | Casting |
| Dan Weil | Production Design |
| Patricia Arango | Art Direction |
| Christina Eunji Kim | Art Direction |
| Justin O'Neal Miller | Art Direction |
| María Fernanda Muñoz | Art Direction |
| Rachel Nowik | Art Department Coordinator |
| Alanna Smith | Art Department Coordinator |
| Douglas Womack | Construction Coordinator |
| Kris Peck | Property Master |
| Elizabeth Cummings | Supervising Art Director |
| Kelley Burney | Set Decoration |
| Kym Barrett | Costume Design |
| Jenny Gering | Costume Design |
| Hayden Bilson | Armorer |
| Jody Blose | Script Supervisor |
| Frédéric North | Aerial Coordinator |
| Jim Garland | Pilot |
| Alan D. Purwin | Pilot |
| Ianthe Jeanne Dugan | Researcher |
| Todd Kasow | Music Editor |
| Tom Kramer | Music Editor |
| Annette Kudrak | Music Editor |
| Gabe Hilfer | Music Supervisor |
| Julianne Jordan | Music Supervisor |
| Mercedes Cook | Assistant Costume Designer |
| Thom Heyer | Assistant Costume Designer |
| Bridget Shields | Assistant Costume Designer |
| Abby Walton | Assistant Costume Designer |
| Chelsea Staebell | Assistant Costume Designer |
| Camila Olarte | Assistant Costume Designer |
| Aimee Campolucci | Ager/Dyer |
| Pam Aaron | Key Costumer |
| Wendy Talley | Key Costumer |
| Fran Beaudry | Seamstress |
| Libby Culligan | Set Costumer |
| Julian Grijalba | Set Costumer |
| Alexyz Danine Kemp | Set Costumer |
| Olivia Vestina Torres | Set Costumer |
| Natasha Romanow | Set Costumer |
| Tom Schmitz | Tailor |
| Dylan Goss | Aerial Director of Photography |
| Christine Oeurn | Camera Technician |
| Christopher TJ McGuire | Steadicam Operator |
| Kelly Clear | Gaffer |
| Kevin Gazdik | Gaffer |
| C. Ashley Sudge | Dolly Grip |
| Michael Duarte | Key Grip |
| James Selph | Key Grip |
| Jerry Chief Parker | Rigging Gaffer |
| Tyler Childs | Rigging Gaffer |
| Tony Murima | Rigging Grip |
| Tommy Donald | Rigging Grip |
| David James | Still Photographer |
| Adam Meadows | Video Assist Operator |
| Edward Button | Additional Photography |
| Eliza Morse | Additional Still Photographer |
| Cristen Clark | Lighting Technician |
| Killian Clear | Lighting Technician |
| Marie Larkin | Hair Department Head |
| Jay Ferrara | Hairstylist |
| Alice Moore | Hairstylist |
| Teresa Morgan | Hairstylist |
| Sarah Monzani | Makeup Department Head |
| Olga Turrini Bernardoni | Makeup Department Head |
| Anthony Brooks | Makeup Artist |
| Jamie Cline | Makeup Artist |
| Laura Dandridge | Makeup Artist |
| Leigh Ann Yandle | Key Makeup Artist |
| Kevin Scott | Animation Director |
| Bryan T. Evans | Matchmove Supervisor |
| Grant Lynch | VFX Editor |
| Greg Takacs | VFX Editor |
| Chris Hamilton | VFX Editor |
| Jae Won D. Lee | Visual Effects Coordinator |
| Jennifer Ramos | Visual Effects Coordinator |
| Justin Rogers-CdeBaca | Visual Effects Coordinator |
| Michael Tanton | Visual Effects Coordinator |
| Sara Woomer | Visual Effects Coordinator |
| Matt Mayer | Visual Effects Editor |
| Jaime Fok | Visual Effects Editor |
| Gayle Busby | Visual Effects Producer |
| Sarah McMurdo | Visual Effects Producer |
| Eric J. Robertson | Visual Effects Producer |
| Justin Ball | Visual Effects Supervisor |
| Craig Calvert | Visual Effects Supervisor |
| Scott Riopelle | Visual Effects Supervisor |
| David Fletcher | Special Effects Supervisor |
| Thomas Kittle | Special Effects Coordinator |
| David K. Nami | Special Effects Coordinator |
| Anthony Ortiz | Boom Operator |
| Branka Mrkic | Dialogue Editor |
| Marko Costanzo | Foley |
| Steven Visscher | Foley |
| Dave Flynch | Foley Editor |
| Paul Hsu | Sound Designer |
| Allan Zaleski | Sound Effects Editor |
| Bob Chefalas | Sound Re-Recording Mixer |
| Tom Fleischman | Sound Re-Recording Mixer |
| Seva Solntsev | Sound Re-Recording Mixer |
| Ron Bochar | Supervising Sound Editor |
| Philip Stockton | Supervising Sound Editor |
| Tif Luckenbill | Digital Intermediate |
| Pete Polyakov | Digital Intermediate |
| James W. Harrison III | First Assistant Editor |
| Arturo Sosa | Assistant Editor |
| Robert Grigsby Wilson | Assistant Editor |
| Elizabeth Robinson | Key Hair Stylist |
| Christophe Beck | Original Music Composer |
| Alison Winter | Associate Producer |
| Brandt Andersen | Executive Producer |
| Michael Bassick | Executive Producer |
| Ray Chen | Executive Producer |
| Terry Dougas | Executive Producer |
| Michael Finley | Executive Producer |
| Eric Greenfeld | Executive Producer |
| Paris Kasidokostas Latsis | Executive Producer |
| Johnny Lin | Executive Producer |
| Philip Moross | Executive Producer |
| Michael Plank | Executive Producer |
| Joshua Skurla | Executive Producer |
| Gary Spinelli | Executive Producer |
| Marcos Tellechea | Executive Producer |
| Jill Ahrens | Co-Executive Producer |
| Ryan Ahrens | Co-Executive Producer |
| Andrés Calderón | Co-Executive Producer |
| Jean-Luc De Fanti | Co-Executive Producer |
| Daniel Lanmi | Co-Executive Producer |
| Beely Lee | Co-Executive Producer |
| Allen Liu | Co-Executive Producer |
| James H. Pang | Co-Executive Producer |
| Lauren Selig | Co-Executive Producer |
| Christopher Woodrow | Co-Executive Producer |
| Leo Shi Young | Co-Executive Producer |
| Rita Harrell | Local Casting |
| Jen Kelley | Local Casting |
| Michael Paraskevas | Music |
| Robert Alonzo | Stunt Coordinator |
| Max Calder | Stunt Double |
| Niko Dalman | Stunt Double |
| Elena Sanchez | Stunt Double |
| Christopher C. Padilla | Stunts |
| Tyler Vogt | Stunts |
| Ben Prine | Set Medic |
| Claire Raskind | Unit Publicist |
| Tyler Hohmann | Location Assistant |
| Andrew Mondshein | Editor |
| Saar Klein | Additional Editor |
| Dylan Tichenor | Additional Editor |
| Amy Lynn Tuttle | Utility Stunts |
| Joey Box | Stunt Coordinator |
