 | Colin Farrell als Jesse James |
 | Scott Caan als Cole Younger |
 | Ali Larter als Zerelda "Zee" Mimms |
 | Gabriel Macht als Frank James |
 | Gregory Smith als Jim Younger |
 | Harris Yulin als Thaddeus Rains - President Rock Northern Rail Road |
 | Kathy Bates als Ma James |
 | Timothy Dalton als Allan Pinkerton |
 | Will McCormack als Bob Younger |
 | Ronny Cox als Doc Mimms - Zee's Dad |
 | Terry O'Quinn als Rollin H. Parker - Rains' Gopher |
 | Nathaniel Arcand als Comanche Tom |
 | Ty O'Neal als Clell Miller |
 | Joe Stevens als Loni Packwood |
 | Barry Tubb als Captain Malcolm |
 | Jack Watkins als Detective |
 | Tom Schuster als Union Officer |
 | Lee Ritchey als Bank Manager |
 | Robin Christian-McNair als Woman (as Robin Christian) |
 | Ed Geldart als Old Man Tucker |
 | Brad Leland als Sheriff |
| Craig Erickson als Deputy |
| Mark Walters als Engineer |
 | Michael Stephen Costello als Senator (as Michael Costello) |
| Jack Gould als Head Teller |
 | Morgana Shaw als Lyla |
 | Brady Coleman als Driver |
 | Richard Andrew Jones als Pastor (as Richard Jones) |
| Steven Bland als Man (as Steven "Dooky" Bland) |
| Jerry Cotton als Teller |
 | Muse Watson als Burly Detective |
| Lane Thomas Wilson als Boy Soldier |
 | Ron Hayden als Union Lieutenant |
 | Darryl Cox als Jenkins |
| Riley Flynn als Union Commander |
| Joe Brown als Pinkerton Commander |
 | Shawn Patrick Nash als Hangman |
| Jessica M.E. Nitsch als Loni's girl (as Jessica M-E Nitsch) |
 | Johnny Bartee als Guitarist (uncredited) |
| Big Skinny Brown als Harlan (uncredited) |
 | Pei-San Brown als Saloon Girl (uncredited) |
| Anne Carr als Gang Horse Rider (uncredited) |
| Steve Crawford als Troublemaker (uncredited) |
 | Frank G. Curcio als Hold-up Victim (uncredited) |
| Lisa Del Dotto als Townsfolk (uncredited) |
| Susan E. Denison als Disappointed Girl (uncredited) |
 | Jeremy Denzlinger als Hyperion Townsfolk (uncredited) |
 | Troy Dillinger als Pinkerton / Sniper (uncredited) |
| Charles E. Gray als Banker (uncredited) |
| Kirk Hunter als Townsfolk (uncredited) |
 | David Jachin Kelley als Sharpshooter (uncredited) |
 | Frank Matthews als Pinkerton Detective (uncredited) |
 | Rana Morrison als Horserider / Passenger on Train (uncredited) |
| Philip Olivas als Townsfolk (uncredited) |
| Marvin Schroeder als Pinkerton Man (uncredited) |
| Michael L. Strange als Reenactor (uncredited) |
 | Chris Warner als Railroad Worker (uncredited) |
 | Gena West als Townsfolk (uncredited) |
 | Paul Wright als Civil War Veteran (uncredited) |
| Les Mayfield | Director |
| Roderick Taylor | Screenplay |
| John Rogers | Screenplay |
| Trevor Rabin | Original Music Composer |
| Russell Boyd | Director of Photography |
| Michael Tronick | Editor |
| Barbara Haberecht | Set Decoration |
| Luke Reichle | Costume Design |
| Cary White | Production Design |
| John Frick | Production Design |
| Pam Dixon | Casting |
| Art Schaefer | Co-Producer |
| Wayne Morris | Co-Producer |
| David Robinson | Co-Producer |
| Jonathan A. Zimbert | Executive Producer |
| Bill Gerber | Producer |
| Roderick Taylor | Story |
| James G. Robinson | Producer |
| Freddie Hice | Stunt Coordinator |
| Wayne Morris | Unit Production Manager |
| Bruce Moriarty | First Assistant Director |
| Stephen Lee Davis | Second Assistant Director |
| Maureen Crowe | Music Supervisor |
| Angel Pine | Post Production Supervisor |
| Michael J. Sullivan | Assistant Art Director |
| Ronn Basquette | Set Designer |
| David Hack | Leadman |
| Christopher Stull | Leadman |
| Don Reddy | Camera Operator |
| Roger Basquette | Video Assist Operator |
| Van Redin | Still Photographer |
| Bill Coe | First Assistant Camera |
| Bobby McMahan | Second Assistant Camera |
| Ralph Watson | "B" Camera Operator |
| Peter Simonite | First Assistant "B" Camera |
| Nina Proctor | Costume Supervisor |
| Stephen M. Chudej | Key Costumer |
| Amy Maner | Set Costumer |
| Leeann Radeka | Set Costumer |
| Gail Hunter | Script Supervisor |
| Pud Cusack | Production Sound Mixer |
| Ross Simpson | Boom Operator |
| Scott Streetman | Cableman |
| Taylor Knight | Hair Department Head |
| Taylor Knight | Makeup Department Head |
| Ron Berkeley | Key Makeup Artist |
| Becki Drake | First Assistant Makeup Artist |
| Melissa Forney | First Assistant Hairstylist |
| Matt Vogel | Special Effects Coordinator |
| Bruno Van Zeebroeck | Special Effects Coordinator |
| Kelly Farrah | Property Master |
| Ray Giron | Assistant Property Master |
| Greg Parsons | Editor |
| James Andrykowski | First Assistant Editor |
| J. Paul Huntsman | Supervising Sound Editor |
| James Simcik | Supervising ADR Editor |
| Benjamin Beardwood | Dialogue Editor |
| Patrick J. Foley | Dialogue Editor |
| Gloria D'Alessandro | Dialogue Editor |
| Jayme S. Parker | Sound Effects Editor |
| Ed Callahan | Sound Effects Editor |
| Christopher S. Aud | Sound Effects Editor |
| Adam Johnston | Sound Effects Editor |
| Patricio A. Libenson | Foley Supervisor |
| Terry Garcia | Assistant Sound Editor |
| Jeff Cranford | Assistant Sound Editor |
| Will Kaplan | Music Editor |
| Steve Kempster | Scoring Mixer |
| Doc McGhee | Music Consultant |
| John T. Reitz | Sound Re-Recording Mixer |
| Gregg Rudloff | Sound Re-Recording Mixer |
| Mark Johnston | Sound Recordist |
| Rick Camera | Sound Recordist |
| David Jobe | Foley Mixer |
| Sandy Garcia | Foley Recordist |
| David Lee Fein | Foley Artist |
| Katherine Rose | Foley Artist |
| Doc Kane | ADR Mixer |
| Jeanette Browning | ADR Recordist |
| Barbara Harris | ADR Voice Casting |
| Thom 'Coach' Ehle | Dolby Consultant |
| Amy Chance | Production Coordinator |
| Shanti Delsarte | Assistant Production Coordinator |
| Katie Tull | Second Second Assistant Director |
| Sheila Allen | Production Accountant |
| Pamela Williamson | First Assistant Accountant |
| Robbie Friedmann | Location Manager |
| Toni Atterbury | Unit Publicist |
| David Wilt | Construction Coordinator |
| Marc Andrus | Key Grip |
| Mike Sheeren | Dolly Grip |
| Key Kolb | Key Rigging Grip |
| Buzzy Burwell | Best Boy Electric |
| Todd Smiley | Rigging Gaffer |
| Murray K. Campbell | Gaffer |
| Cecil D. Evans | Transportation Coordinator |
| Ronald D. Chambers | Transportation Captain |
| Joe Fiske | Craft Service |
| Michael Buster | Dialect Coach |
| Tim Monich | Dialect Coach |
| Mat Beck | Visual Effects Supervisor |
| Cindy Jones | Visual Effects Producer |
| Colin Strause | 3D Supervisor |
| Erik Liles | 2D Supervisor |
| Terry Leonard | Second Unit Director |
| Paul Varrieur | Second Unit Director of Photography |
| Robert McLachlan | Second Unit Director of Photography |
| David Cass Jr. | Second Unit First Assistant Director |
| Gary Burritt | Negative Cutter |
| David Orr | Color Timer |
| David E. Campbell | Sound Re-Recording Mixer |
| Troy Gilbert | Stunts |
| Tad Griffith | Stunts |
| Steve M. Davison | Stunts |
| John C. Meier | Stunts |
| Ronnie Rondell Jr. | Stunts |
| Billy D. Lucas | Stunts |
| Erik Rondell | Stunts |
| Casey O'Neill | Stunt Double |
