 | Jennifer Lopez als Terri Flores |
 | Ice Cube als Danny Rich |
 | Jon Voight als Paul Serone |
 | Eric Stoltz als Dr. Steven Cale |
 | Jonathan Hyde als Warren Westridge |
 | Owen Wilson als Gary Dixon |
 | Kari Wuhrer als Denise Kalberg |
 | Vincent Castellanos als Mateo |
 | Danny Trejo als Poacher |
 | Frank Welker als Anaconda (voice) (uncredited) |
| Randy Edelman | Original Music Composer |
| Michael R. Miller | Editor |
| Carole Little | Producer |
| Leonard Rabinowitz | Producer |
| Bill Butler | Director of Photography |
| Susan Ruskin | Executive Producer |
| Luis Llosa | Director |
| Verna Harrah | Producer |
| Gregory Nutt | Transportation Co-Captain |
| Stelvio Rosi | Line Producer |
| Beau Marks | Co-Producer |
| Mindy Marin | Casting |
| Andy Fickman | Associate Producer |
| Jack Epps Jr. | Producer |
| James Dyer | Unit Production Manager |
| Thomas W. Lay Jr. | Production Illustrator |
| Louis Medrano | Painter |
| Walt Fraser | Camera Operator |
| K.C. Colwell | First Assistant Director |
| Kimberly Harris | ADR Supervisor |
| Robin Griffin | Visual Effects Producer |
| Kathy Monderine | Costume Design |
| Justin J. LaPresle | Propmaker |
| Scott Anderson | Visual Effects Editor |
| Laurence Cropley | Lighting Technician |
| Bill Houston Ball | Visual Effects |
| Tom Reta | Assistant Art Director |
| Barbara Mesney | Set Designer |
| Toca Seabra | Aerial Camera |
| Dino Ganziano | Hairstylist |
| Jon Aguilar | Set Dressing Artist |
| Jennifer Badger | Stunts |
| Richard C. Franklin | Supervising Sound Editor |
| Robert Ulland | Steadicam Operator |
| Gala Autumn | Set Costumer |
| Guy Moon | Orchestrator |
| Barry Chusid | Art Direction |
| Todd Johnson | Craft Service |
| Tracy Farrington | Property Master |
| Kirk M. Petruccelli | Production Design |
| John F. Teeple | Driver |
| Vanessa Grayson | Stand In |
| Webster Whinery | Stunt Coordinator |
| Glen Harmon | Greensman |
| Kris Fullan Martinez | Production Coordinator |
| Jacquie Barnbrook | Visual Effects Coordinator |
| Kevin A. Canamar | Set Medic |
| John H. Arrufat | Dialogue Editor |
| Simon Coke | Sound Effects Editor |
| Philip Sloan | Key Grip |
| Steve Blumenkrantz | Animatronic and Prosthetic Effects |
| Daniel Loren May | Set Decoration |
| David Tanner | Software Engineer |
| Destiny Borden | First Assistant Sound Editor |
| Michael Muscarella | Construction Coordinator |
| Adam Martyn | Sculptor |
| Serge Genitempo | Standby Painter |
| Alex Touyarot | First Assistant Camera |
| Gary A. Beaird | Grip |
| Gene Kelly | Production Accountant |
| Steve Birkett | Boom Operator |
| John Nelson | Visual Effects Supervisor |
| Pete Romano | Underwater Camera |
| Donna Barrett Gilbert | Key Hair Stylist |
| Greg Nutt | Transportation Captain |
| Deborah Laub | Location Manager |
| Serge Sretschinsky | Supervising Technical Director |
| Mira Tweti | Unit Publicist |
| Dale E. Grahn | Color Timer |
| Michael Douglas Middleton | Still Photographer |
| David Maddux | Gaffer |
| John Papsidera | Casting Associate |
| Joanie Diener | Music Editor |
| Randy Bostic | Leadman |
| Ken Diaz | Makeup Artist |
| Roy Bean | Video Assist Operator |
| Douglas B. Arnold | Sound Mixer |
| Chuck Gaspar | Special Effects Supervisor |
| Martin A. Kline | Visual Effects Art Director |
| Caique Martins Ferreira | Production Manager |
| Roberto Carneiro | Costumer |
| Jim Marquette | Assistant Camera |
| Jane E. Graves | Assistant Location Manager |
| Fred Aghajanian | Production Assistant |
| Lisanne Sartor | Second Second Assistant Director |
| Walter Royle | Best Boy Grip |
| Kelvin Lee | Lead Animator |
| Nerses Gezalyan | Foley Mixer |
| Valeria Costa Amorim | Assistant Production Manager |
| Justine Hebron | Assistant Production Coordinator |
| Colin Campbell | Compositing Lead |
| Gary A. Hecker | Foley Artist |
| Gu Ramalho | Camera Loader |
| Pedro Moraes | Camera Trainee |
| Ann Monn | VFX Artist |
| David J. Negrón Jr. | Storyboard Artist |
| Rick Senteno | Assistant Chief Lighting Technician |
| Marcela Bourseau | Second Assistant Camera |
| Xochi Blymyer | Second Assistant Director |
| Anthony Ceccomancini | Pre-Visualization Coordinator |
| Beau Marks | Second Unit Director |
| Tony Allard | Special Effects Technician |
| Edward C. Peters | Dolly Grip |
| Avram D. Gold | ADR Editor |
| Inéz Salgado Miranda | Wardrobe Assistant |
| Michael Neal | Payroll Accountant |
| Nancy Huffman | Special Effects Assistant |
| Mo Henry | Negative Cutter |
| Tiffany Fraser | First Assistant Accountant |
| Richard Harrah | Production Executive |
| Chuck Picerni Jr. | Stunts |
| Hans Bauer | Writer |
| Jack Epps Jr. | Writer |
| Jim Cash | Writer |
| Stephanie Finochio | Stunt Double |
| Patricia Eskenazi | Stunt Double |
| Terry Jackson | Stunt Double |
| Dain Turner | Stunts |
| Tierre Turner | Stunts |
| Patrick J. Statham | Stunts |
| April Weeden | Stunts |
| Eddie L. Watkins | Stunts |
| Nick Brett | Stunts |
| Phil Culotta | Stunts |
| Sandy Berumen | Stunts |
| Carol Daniels | Stunts |
| Richard Epper | Stunts |
| J. Mark Donaldson | Stunts |
| Terry James | Stunts |
| Mickey Giacomazzi | Stunts |
| Denney Pierce | Stunts |
| Hugh Aodh O'Brien | Stunts |
| James Ryan | Stunts |
| Dennis Scott | Stunts |
| Jeff Podgurski | Stunts |
| Mike Smith | Stunts |
