 | Jeff Daniels als Dr. Ross Jennings |
 | Harley Jane Kozak als Molly Jennings |
 | John Goodman als Delbert McClintock |
 | Julian Sands als Doctor James Atherton |
 | Brian McNamara als Chris Collins |
 | Stuart Pankin als Sheriff Lloyd Parsons |
 | Henry Jones als Doctor Sam Metcalf |
 | Peter Jason als Henry Beechwood |
 | Mark L. Taylor als Jerry Manley |
 | James Handy als Milton Briggs |
 | Roy Brocksmith als Irv Kendall |
 | Kathy Kinney als Blaire Kendall |
 | Mary Carver als Margaret Hollins |
 | Garette Ratliff Henson als Tommy Jennings |
 | Marlene Katz als Shelley Jennings |
| Jane Marla Robbins als Edna Beechwood |
| Theo Schwartz als Bunny Beechwood |
| Cori Wellins als Becky Beechwood |
| Chance Boyer als Bobby Beechwood |
 | Frances Bay als Evelyn Metcalf |
 | Lois de Banzie als Henrietta Manley |
| Warren Rice als Dick Manley |
| Robert Frank Telfer als Mayor Bob |
| Michael Steve Jones als Irv's Assistant |
| Fiona Walsh als Little Girl |
| Terese Del Piero als Mom |
| Nathaniel Spitzley als Todd Miller |
| Jay Scorpio als Mover |
 | Mai-Lis Kuniholm als Girlfriend |
| Robert 'Bobby Z' Zajonc als Reserve Pilot |
 | Juan Fernández als Miguel Higueras (uncredited) |
| Mikael Salomon | Director of Photography |
| Wesley Strick | Screenplay |
| Frank Marshall | Executive Producer |
| Steven Spielberg | Executive Producer |
| Don Jakoby | Screenplay |
| Frank Marshall | Director |
| Kathleen Kennedy | Producer |
| Trevor Jones | Original Music Composer |
| Richard Vane | Producer |
| Michael Kahn | Editor |
| William S. Beasley | Associate Producer |
| Robert W. Cort | Co-Executive Producer |
| Ted Field | Co-Executive Producer |
| Al Williams | Story |
| Don Jakoby | Co-Producer |
| Mike Fenton | Casting |
| Judy Taylor | Casting |
| Valorie Massalas | Casting |
| James D. Bissell | Production Design |
| Don Jakoby | Story |
| Christopher Burian-Mohr | Art Direction |
| William S. Beasley | Unit Production Manager |
| Bruce Cohen | First Assistant Director |
| David D'Ovidio | Second Assistant Director |
| Chuck Waters | Stunt Coordinator |
| Robert 'Bobby Z' Zajonc | Pilot |
| Edward T. McAvoy | Assistant Art Director |
| Jackie Carr | Set Decoration |
| Tim Donelan | Leadman |
| Max E. Brehme | Set Dresser |
| Don Kaeding | Set Dresser |
| Mike Carrillo | Set Dresser |
| Suzanne Lee Peck | Art Department Coordinator |
| Louis S. Fleming | Property Master |
| Gary F. Kieldrup | Assistant Property Master |
| Gus Feederle | Assistant Property Master |
| Julie Pitkanen | Script Supervisor |
| James Lee McCoy | Makeup Artist |
| David Quashnick | Makeup Artist |
| Carolyn Elias | Hairstylist |
| Dione Taylor | Hairstylist |
| Jennifer L. Parsons | Costume Design |
| Eric J. Goldstein | Camera Operator |
| Ian Fox | First Assistant Camera |
| David Luckenbach | Second Assistant Camera |
| Rebecca Baehler | Camera Loader |
| Ralph Nelson Jr. | Still Photographer |
| Ron Judkins | Sound Mixer |
| Robert Jackson | Boom Operator |
| Randy McDonald | Cableman |
| Richmond G. Cogswell | Video Assist Operator |
| Dwight Campbell | Gaffer |
| Bobby Huber | Key Grip |
| Jesse Chavez | Best Boy Grip |
| Jimmy Leavens | Dolly Grip |
| Jack Glenn | Grip |
| Paul Iski | Grip |
| Matt Sweeney | Special Effects Supervisor |
| David Sosalla | Visual Effects Supervisor |
| Alison Savitch | Visual Effects Coordinator |
| Dan Marrow | Transportation Coordinator |
| Randy Burke | Transportation Captain |
| Ernie Depew | Construction Coordinator |
| Thomas A. Carlson | Music Editor |
| Terry Porter | Sound Re-Recording Mixer |
| David J. Hudson | Sound Re-Recording Mixer |
| Mel Metcalfe | Sound Re-Recording Mixer |
| Tom C. McCarthy | Supervising Sound Editor |
| Marsha Robertson | Unit Publicist |
| Barbara Harris | ADR Voice Casting |
| Gary Burritt | Negative Cutter |
| Stephen R. Sheridan | Color Timer |
| Hilda Hodges | Foley Artist |
| Richard Friedman | Supervising ADR Editor |
| R.J. Kizer | Supervising ADR Editor |
| Chris Walas | Creature Effects Technical Director |
| Spice Williams-Crosby | Stunts |
