 | Jack Nicholson als Melvin Udall |
 | Helen Hunt als Carol Connelly |
 | Greg Kinnear als Simon Bishop |
 | Cuba Gooding Jr. als Frank Sachs |
 | Shirley Knight als Beverly Connelly |
 | Jesse James als Spencer Connelly |
 | Yeardley Smith als Jackie Simpson |
 | Lupe Ontiveros als Nora Manning |
 | Skeet Ulrich als Vincent Lopiano |
 | Harold Ramis als Dr. Bettes |
 | Bibi Osterwald als Neighbor Woman |
 | Ross Bleckner als Carl |
 | Bernadette Balagtas als Caterer |
 | Jaffe Cohen als Partygoer |
| Laurie Kilpatrick als Partygoer |
 | Alice Vaughn als Partygoer |
 | Brian Doyle-Murray als Handyman |
 | Kristi Zea als Mother at Table |
 | Annie Maginnis Tippe als Daughter at Table |
 | Patricia Childress als Cafe 24 Waitress |
 | Rebekah Johnson als Cafe 24 Waitress |
 | Missi Pyle als Cafe 24 Waitress |
 | Leslie Stefanson als Cafe 24 Waitress |
 | Tara Subkoff als Cafe 24 Waitress |
 | Shane Black als Cafe 24 Manager |
 | Peter Jacobson als Man at Table |
 | Lisa Edelstein als Woman at Table |
| Stan Bly als Cafe 24 Customer |
 | Randall Batinkoff als Carol's Date |
 | Jamie Kennedy als Street Hustler |
| Justin Herwick als Street Hustler |
 | Maya Rudolph als Policewoman |
| John F. O'Donohue als Detective Ray |
| David A. Kipper als Hospital Doctor |
| Mary Elizabeth Still als Nurse Receptionist |
| Chloe Brooks als Child at Cafe 24 |
| Cooper Brooks als Child at Cafe 24 |
| Sharon L. Alexander als Female Passerby |
| Holly Denys als Female Passerby |
 | Lawrence Kasdan als Dr. Green |
| Alison Rose als Psychiatric Patient |
 | Kathryn Morris als Psychiatric Patient |
 | Wood Harris als Cafe 24 Busboy |
 | Linda Gehringer als Publisher |
 | Julie Benz als Receptionist |
 | Antonia Jones als Nurse |
 | Kaitlin Hopkins als Woman in Lobby |
 | Jimmy Workman als Sean from the Bakery |
 | Todd Solondz als Man on Bus |
 | Tom McGowan als Maitre D' |
 | Danielle Brisebois als Singer |
 | Matt Malloy als Men's Store Salesman |
 | Paul Greenberg als Bar Waiter |
| Kirk Ringberg als Food Waiter |
| Dave Hawthorne als Bartender |
| Alex Ballar als Flower Store Customer (uncredited) |
| Dunya Djordjevic als Art Dealer (uncredited) |
| Frank Slaten als Miffed Party Goer (uncredited) |
| Laura Mayes Byrnes als Restaurant Patron (uncredited) |
| Oriana Nicole Tavoularis als Restaurant Patron (uncredited) |
| Roger Ferreira als Restaurant Patron (uncredited) |
| Jason Thomas Campbell als Valet (uncredited) |
| Amy Anzel als Ballet Dancer (uncredited) |
| Eliza Harris als Ballet Dancer (uncredited) |
| Eddie L. Fauria als NYC Transit Cop (uncredited) |
| Bronwyn Cornelius als Bartender (uncredited) |
 | Maurice LaMarche als Fred Bishop - Simon's Dad on Phone (voice) (uncredited) |
| Mark Andrus | Screenplay |
| James L. Brooks | Producer |
| James L. Brooks | Screenplay |
| James L. Brooks | Director |
| Ray Quiroz | Script Supervisor |
| Walter Scott | Stunt Coordinator |
| Philip Toolin | Art Direction |
| Julie Ansell | Thanks |
| Owen Wilson | Associate Producer |
| Molly Maginnis | Costume Design |
| Gena Bleier | Assistant Editor |
| Hans Berggren | Other |
| Francine Maisler | Casting |
| Ralph Nelson Jr. | Still Photographer |
| Carrie Angland | Makeup Artist |
| Bruce Fowler | Orchestrator |
| Michael Besman | Thanks |
| John Bailey | Director of Photography |
| Bill Brzeski | Production Design |
| Clay A. Griffith | Set Decoration |
| Karen E. Etcoff | Casting |
| Richard Marks | Editor |
| Susan Perlman | Other |
| Chester E. Tripp III | Stunts |
| Greg Addison | Lighting Technician |
| Mark Andrus | Story |
| Dennis Drummond | Supervising Sound Editor |
| Julia Davis | Stunt Double |
| Julia Davis | Stunt Coordinator |
| BJ Davis | Stunt Double |
| Hilary Schroeder | Assistant Editor |
| Denise Lynne Roberts | Stunts |
| Pablo Ferro | Title Designer |
| Barbara Harris | ADR Voice Casting |
| Tim McGovern | Visual Effects Supervisor |
| Mark Wade | Property Master |
| Armen Ksajikian | Musician |
| Aldric La'Auli Porter | Associate Producer |
| Maria Kavanaugh | Associate Producer |
| John D. Schofield | Co-Producer |
| Richard Marks | Co-Producer |
| Richard Sakai | Executive Producer |
| Laurence Mark | Executive Producer |
| Laura Ziskin | Executive Producer |
| Bridget Johnson | Producer |
| Kristi Zea | Producer |
| Ken Fritz | Stunt Coordinator |
| Jake Jacobson | Unit Production Manager |
| John D. Schofield | Unit Production Manager |
| Aldric La'Auli Porter | First Assistant Director |
| William M. Connor | Second Assistant Director |
| David Giammarco | Supervising Sound Editor |
| Masako Masuda | Assistant Art Director |
| Brana Rosenfeld | Assistant Set Decoration |
| John Naehrlich | Leadman |
| John Hammer Maxwell | Set Dresser |
| Bart C. Hubenthal | Set Dresser |
| Scott G. Jones | Set Dresser |
| John Maskovich | Set Dresser |
| Michael Stone | Camera Operator |
| Donald E. Thorin Jr. | First Assistant Camera |
| Michael Martinez | Second Assistant Camera |
| Renée Tondelli | ADR Supervisor |
| Patrick Drummond | Sound Effects Editor |
| Cindy Marty | Sound Effects Editor |
| Nicholas Korda | ADR Editor |
| Jonathan Klein | Foley Editor |
| Christopher Flick | Foley Editor |
| Zigmund Gron | Music Editor |
| Galen Goodpaster | First Assistant Sound Editor |
| Kira Edmunds | Assistant Sound Editor |
| Bill Ward | Assistant Sound Editor |
| Chris Jenkins | Sound Re-Recording Mixer |
| Ron Bartlett | Sound Re-Recording Mixer |
| Mark Smith | Sound Re-Recording Mixer |
| Andy Malcolm | Foley Artist |
| Richard Duarte | Foley Mixer |
| Thomas J. O'Connell | ADR Mixer |
| Jeff Gomillion | ADR Mixer |
| Rudy Pi | Sound Recordist |
| Matt Colleran | Sound Recordist |
| Jeffrey Pollack | Music Supervisor |
| Adam Milo Smalley | Music Editor |
| Jeff Wexler | Sound Mixer |
| Don Coufal | Boom Operator |
| Gary Holland | Cableman |
| Mike Moyer | Chief Lighting Technician |
| David Burnett | Assistant Chief Lighting Technician |
| Michael M. Krevitt | Key Grip |
| Thomas Wazney | Best Boy Grip |
| Michael Connors | Dolly Grip |
| William B. Doane | Special Effects Coordinator |
| Donna Casey-Aira | Assistant Costume Designer |
| Elaine Ramires | Wardrobe Supervisor |
| Mary Elizabeth Still | Costumer |
| James Lapidus | Costumer |
| Michèle Burke | Makeup Supervisor |
| Stacye P. Branche | Makeup Artist |
| Darrell Redleaf-Fielder | Hairstylist |
| Linda Arnold | Hair Supervisor |
| Joy Zapata | Hairstylist |
| Ralph Coleman | Location Manager |
| S. Todd Christensen | Assistant Location Manager |
| Gary Deaton | Construction Coordinator |
| Yvonne Yaconelli | Production Office Coordinator |
| Martin Charles | Graphic Designer |
| George Merkert | Visual Effects Producer |
| Theresa Repola Mohammed | Negative Cutter |
| Dale E. Grahn | Color Timer |
| Gene LeBell | Stunts |
| Hans Zimmer | Original Music Composer |
| Felipe Savahge | Stunts |
| Bruce Gregory | Stunts |
| Phil O'Dell | Stunts |
| David LeBell | Stunts |
