 | Kurt Russell als Stephen McCaffrey |
 | William Baldwin als Brian McCaffrey |
 | Robert De Niro als Donald Rimgale |
 | Donald Sutherland als Ronald Bartel |
 | Jennifer Jason Leigh als Jennifer Vaitkus |
 | Scott Glenn als John 'Axe' Adcox |
 | Rebecca De Mornay als Helen McCaffrey |
 | Jason Gedrick als Tim Kirzminski |
 | J.T. Walsh als Alderman Marty Swayzak |
 | Anthony Mockus Sr. als Chief John Fitzgerald |
| Cedric Young als Grindle |
 | Juan Ramírez als Ray Santos |
| Kevin Casey als Nightingale |
 | Jack McGee als Schmidt |
| Mark Wheeler als Pengelly |
| Richard Lexsee als Washington |
| Beep Iams als Sean McCaffrey |
| Ryan Goldstein als Brian, Age 7 |
| John Duda als Stephen - Age 12 |
 | Robert Swan als Willy - Bartender |
 | Clint Howard als Ricco, Pathologist |
 | Ron West als Alan Seagrave |
 | Kevin Crowley als Candidate |
 | Carlos Sanz als Candidate |
 | Jane Jenkins als Woman Psychiatrist |
 | David Crosby als '70s Hippie |
 | W. Earl Brown als Paramedic |
 | James Ritz als Mannequin Fire Reporter |
 | Irma P. Hall als Nurse |
| Nydia Rodriguez Terracina als Nurse |
| Dennis Liddiard als Party Brawler |
| David Luckenbach als Security Officer |
| Gregory Lundsgaard als High-Rise Fireman |
| Dan Tullis Jr. als Engine 17 Firefighter |
| Peter C. Hobert als Probie |
| Ron Howard | Director |
| Gregory Widen | Writer |
| Richard Barton Lewis | Producer |
| Raffaella De Laurentiis | Executive Producer |
| Brian Grazer | Executive Producer |
| Hans Zimmer | Original Music Composer |
| Mikael Salomon | Director of Photography |
| Daniel P. Hanley | Editor |
| Mike Hill | Editor |
| Pen Densham | Producer |
| Larry DeWaay | Co-Producer |
| John Watson | Producer |
| Janet Hirshenson | Casting |
| Todd Hallowell | Associate Producer |
| Jane Jenkins | Casting |
| Pierre Remy | Chef |
| John Burros | Stand In |
| Shirley Walker | Orchestrator |
| Albert Brenner | Production Design |
| Carol Winstead Wood | Art Direction |
| Garrett Lewis | Set Decoration |
| Jodie Lynn Tillen | Costume Design |
| Gregory A. Weimerskirch | Assistant Art Director |
| Steve A. Hagberg | Construction Coordinator |
| Richard Bryan Douglas | Construction Foreman |
| Steve Homa | Greensman |
| David Conaghan | Leadman |
| Larissa Supplitt | Location Scout |
| Anthony Joseph Fatigato | Painter |
| Peter Ramsey | Production Illustrator |
| Gary Baugh | Set Designer |
| Alan Broadbent | Standby Painter |
| Robert L. Blatman | Camera Operator |
| Josh Bleibtreu | First Assistant Camera |
| Dick Dova | Key Grip |
| Gregory Lundsgaard | Steadicam Operator |
| Phillip V. Caruso | Still Photographer |
| Denise Wingate | Assistant Costume Designer |
| John Casey | Costume Supervisor |
| Ilona Herman | Hairstylist |
| Linda Rizzuto | Key Hair Stylist |
| Dennis Liddiard | Makeup Artist |
| Lance Anderson | Prosthetic Makeup Artist |
| Jane Blank | Seamstress |
| Gloria Coffey-Sharrieff | Set Costumer |
| Lawrence Hammer | Carpenter |
| Monica Devereux | Choreographer |
| Raymond Bulinski | Craft Service |
| Todd Dickison | Driver |
| George Dougherty | Loader |
| Andrew Golov | Post Production Supervisor |
| Shari Lynn Himes | Production Office Assistant |
| Dennis J. Parrish | Property Master |
| Walter Scott | Stunt Coordinator |
| William Baldwin | Stunts |
| Todd Dickison | Transportation Co-Captain |
| Calvin Chin | Transportation Coordinator |
| Larry DeWaay | Unit Production Manager |
| Andrew Lipschultz | Unit Publicist |
| Jack Gallagher | First Assistant Director |
| Sioux Richards | Script Supervisor |
| Roger Tweten | First Assistant Editor |
| Rob Doherty | Electrician |
| Alphonse Blumenthal | Gaffer |
| Todd Braden | Lighting Technician |
| Jacqueline King | Casting Associate |
| Jim Morris | Executive In Charge Of Production |
| Michael J. Malone | Location Manager |
| Cheryl A. Stone | Production Accountant |
| Alecia LaRue | Production Coordinator |
| Jeffrey A. Williams | Boom Operator |
| Becky Mancuso-Winding | Music Supervisor |
| Jay Rifkin | Scoring Mixer |
| Dennis Leonard | Sound Engineer |
| Curt Frisk | Sound Mixer |
| Richard Hymns | Supervising Sound Editor |
| Robert Finley Jr. | Pyrotechnic Supervisor |
| Anne Calanchini | Visual Effects Coordinator |
| Suella Kennedy | Visual Effects Producer |
| Scott Farrar | Visual Effects Supervisor |
| Mark Moore | Storyboard |
| Robert E. Knight | Sign Painter |
| Paul Huston | Visual Effects Art Director |
| W. Earl Brown | Dialect Coach |
| John S. Robertson | Key Grip |
| David Orr | Color Timer |
| Sara Bolder | Dialogue Editor |
| Michael Silvers | Dialogue Editor |
| Gary Isbell | Set Dresser |
| Todd Hallowell | Second Unit Director |
| Sandina Bailo-Lape | Foley Editor |
| Vivien Hillgrove Gilliam | ADR Editor |
| Marilyn McCoppen | ADR Editor |
| Rob Fruchtman | ADR Editor |
| Diana Pellegrini | Foley Editor |
| Dennie Thorpe | Foley Artist |
| Mary Helen Leasman | Foley Editor |
| Marnie Moore | Foley Artist |
| Christopher Boyes | Foley Recordist |
| Mark Sullivan | Matte Painter |
| Haleen K. Holt | Costume Illustrator |
| Jeff Okabayashi | Second Second Assistant Director |
| Michael D. Gianneschi | Construction Buyer |
| Walter J. Piers | Swing |
| Wayne Fitzgerald | Title Designer |
| Ed Golya | ADR Mixer |
| William L. Allen Sr. | Special Effects Technician |
| Martin Rosenberg | Visual Effects Camera |
| John Casino | Stunt Double |
| Mollie S. Mallinger | Additional Second Assistant Camera |
| Robert Hill | Assistant Camera |
| Bill Barr | Best Boy Grip |
| Chris Freres | Dolly Grip |
| Joe Carroll | Second Assistant Camera |
| Guy Barresi | Assistant Editor |
| Tom Rovak | Colorist |
| Louis Rivera | Negative Cutter |
| Stephen Andrzejewski | Assistant Location Manager |
| Betsy Horning | Location Assistant |
| Shirley Walker | Conductor |
| Celest Ray | Music Coordinator |
| Louise C. Larson | Assistant Production Coordinator |
| Dwight Campbell | Chief Lighting Technician |
| Joan Philo | Extras Casting Assistant |
| Scott Ross | General Manager |
| Eugene F. Crededio | Generator Operator |
| Paul Andresen | Production Assistant |
| Wileen Dragovan | Production Secretary |
| Reuben Goldberg | Pyrotechnician |
| Tom Bertino | Rotoscoping Artist |
| William Cosgrove | Technical Advisor |
| Gary Rydstrom | Sound Designer |
| Gary Rydstrom | Sound Re-Recording Mixer |
| Gary Summers | Sound Re-Recording Mixer |
| Randy Thom | Sound Re-Recording Mixer |
| Mike Johnson | Stunts |
| Terry Leonard | Stunts |
| Tony Brubaker | Stunts |
| Corey Michael Eubanks | Stunts |
| Norman Howell | Stunts |
