 | Nicolas Cage als Terence McDonagh |
 | Eva Mendes als Frankie Donnenfeld |
 | Val Kilmer als Stevie Pruit |
 | Fairuza Balk als Heidi |
 | Shawn Hatosy als Armand Benoit |
 | Jennifer Coolidge als Genevieve |
 | Tom Bower als Pat McDonagh |
 | Vondie Curtis-Hall als Captain James Brasser |
 | Irma P. Hall als Binnie Rogers |
 | Shea Whigham als Justin |
 | Michael Shannon als Mundt |
 | Brad Dourif als Ned Schoenholtz |
 | Xzibit als Big Fate |
 | Denzel Whitaker als Daryl |
 | Joe Nemmers als Larry Moy |
 | J.D. Evermore als Rick Fitzsimon |
 | Tim Bellow als G (Gary Jenkins) |
 | Lucius Baston als Midget |
| Lauren Swinney als Antoinette |
 | Nick Gomez als Evaristo Chavez |
 | Sam Medina als Andy |
 | Lance E. Nichols als Jeremiah Goodhusband |
 | Tony Bentley als Hurley |
| Jeremy Aaron Johnson als Yasco |
| Bernard Johnson als Dub |
| Matt Borel als Bernie |
 | Gary Grubbs als Chief of Police |
 | J. Omar Castro als First Narcotics Detective |
 | Kerry Cahill als Second Narcotics Detective |
 | Noel Arthur als Renaldo Hayes |
 | Douglas M. Griffin als Sergeant |
| Jedda Jones als Civilian Aide |
| Lauren Pennington als Woman |
 | Dane Rhodes als Bettor |
 | Don Yesso als Client |
 | Trey Burvant als Dealer |
| Robert Pavlovich als Dr. Milburn |
 | Marco St. John als Eugene Gratz |
 | David Joseph Martinez als Juan Michel |
 | Kyle Clements als Lawrence |
| Deena Beasley als Maimouna |
 | Deneen Tyler als Pharmacist |
 | Roger J. Timber als Security Guard |
| Joshua Joseph Gillum als Host |
 | Sean Boyd als Lt. Stoyer |
| Katie Chonacas als Tina |
 | Brandi Coleman als Yvonne |
| Michael Zimbrich als Waiter |
| Trenton Perez als Boy |
 | Stephanie Honoré als Girl |
| Katrell Dixon als Witness #1 |
| Stiggidy Steve als Witness #2 |
 | Armando Leduc als Jeff |
 | Jillian Batherson als Assistant to D.A. |
| Scheryl W Brown als Police Officer (uncredited) |
| Geraldine Glenn als Family Member (uncredited) |
| Ted Jordan als Detective (uncredited) |
 | William M. Finkelstein als Dave Jacobs |
| Werner Herzog | Director |
| Edward R. Pressman | Producer |
| Stephen Belafonte | Producer |
| Randall Emmett | Producer |
| Alan Polsky | Producer |
| John Thompson | Producer |
| Alessandro Camon | Executive Producer |
| Boaz Davidson | Executive Producer |
| Danny Dimbort | Executive Producer |
| Avi Lerner | Executive Producer |
| Elliot Lewis Rosenblatt | Executive Producer |
| Trevor Short | Executive Producer |
| Mark Isham | Original Music Composer |
| Peter Zeitlinger | Director of Photography |
| Joe Bini | Editor |
| William M. Finkelstein | Writer |
| Gabe Polsky | Producer |
| Jenny Jue | Casting |
| Johanna Ray | Casting |
| Toby Corbett | Production Design |
| Leonard R. Spears | Set Decoration |
| Jill Newell | Costume Design |
| Stacy Kelly | Makeup Department Head |
| Cathy Gesualdo | Production Manager |
| Chuck Stringer | Construction Coordinator |
| Pat A. O'Connor | Leadman |
| John Blanchard | Construction Foreman |
| Christina Eunji Kim | Set Designer |
| Brent Findley | Sound Effects Editor |
| Jonathan Wales | Sound Re-Recording Mixer |
| David K. Nami | Special Effects Coordinator |
| Veselina Georgieva | Visual Effects Supervisor |
| Russell Towery | Stunt Coordinator |
| Lena Herzog | Still Photographer |
| Paul Olinde | Gaffer |
| Tarik Naim Alherimi | Best Boy Electric |
| S. Aimee Helms | Set Costumer |
| Ann Walters | Costume Supervisor |
| Danny Mortenson | Transportation Coordinator |
| Batou Chandler | Location Manager |
| Amy Sanderson | Script Supervisor |
| Malikka Coston | Key Set Costumer |
| Paul Anthony Morris | Key Hair Stylist |
| Michael Zimbrich | First Assistant Director |
| Vince LeBlanc | Set Dresser |
| Ashley Waldron | Music Supervisor |
| Stanford Gilbert | Armorer |
| Donna Spahn | Hair Department Head |
| Margot Boccia | Makeup Artist |
| Aimee Stuit | Key Makeup Artist |
| George Bott | Second Assistant Director |
| Rachel Nowik | Art Department Assistant |
| Troy A. Johnson | Construction Buyer |
| George Sanchez | Painter |
| Stanford Gilbert | Property Master |
| William Burck | Prop Maker |
| Luke Cauthern | Set Dresser |
| Gregory T. Geniusz | Set Dresser |
| Lawrence Heap | Set Dresser |
| Erik Söllner | Assistant Camera |
| Gerald Autin | Best Boy Grip |
| Brad Garris | Electrician |
| D.H. Jacobs | Electrician |
| Michael Charbonnet | First Assistant Camera |
| Duane Cooper | Grip |
| Jonathan Stoll | Grip |
| Barry Williamson | Grip |
| Ferdinand Duplantier Jr. | Rigging Gaffer |
| Penelope Helmer | Second Assistant Camera |
| Jerry M. Jacob | Second Unit Cinematographer |
| Jim Mayo | Techno Crane Operator |
| Jason Landry | Casting Associate |
| Robin Batherson | Extras Casting |
| Lauren Bott | Assistant Costume Designer |
| Jen Wasson | Costume Assistant |
| Alexandra Eagle | Costumer |
| Meagan McLaughlin | Costumer |
| D.J. Shea | Compositor |
| Kremena Ganeva | Digital Compositor |
| Delyan Ketipov | Digital Compositor |
| Momchil Kirov | Digital Compositor |
| Stanislav Draganov | Visual Effects |
| Kiril Georgiev | Visual Effects Coordinator |
| Angelina Borisowa | Visual Effects Editor |
| Jason Gaya | ADR Mixer |
| Judah Getz | ADR Mixer |
| Corey J. Grasso | ADR Mixer |
| Tiffany Lentz | Assistant Sound Editor |
| Randy Pease | Boom Operator |
| Walter Spencer | Dialogue Editor |
| Zach Michaelis | Foley Artist |
| Joshua Adeniji | Foley Editor |
| Levent Erdogan | Foley Editor |
| Jay Meagher | Sound Mixer |
| Chris J. Fanguy | Animal Wrangler |
| Mark Micucci | Post Production Accountant |
| Steev Beeson | Production Accountant |
| Alan J. Lam | Production Controller |
| Anthony Rossi III | Production Coordinator |
| Sam Horton | Production Secretary |
| Omar Daher | Assistant Editor |
| David Graubard | Digital Intermediate |
| Kurt Tuffendsam | Digital Intermediate |
| Julius Friede | Digital Intermediate Colorist |
| Jon Pehlke | Digital Intermediate Editor |
| Chris Ward | Digital Intermediate Producer |
| Ilona Herman | Hairstylist |
| Ilona Herman | Makeup Artist |
| Nikki I Brown | Makeup Artist |
| Darryl Lucas | Makeup Artist |
| René Besson | Executive In Charge Of Production |
| Jerry Gilbert | Post Production Supervisor |
| Todd Gilbert | Executive In Charge Of Post Production |
| Joseph Lobato | Post-Production Manager |
| Sarah Parker | Executive In Charge Of Production |
| Sherman Shelton Jr. | Second Second Assistant Director |
| Scott C. Bivona | Greensman |
| Gail Briant | Scenic Artist |
| Janna Roach | First Assistant Property Master |
| Wayne Softley Jr. | Set Painter |
| Michael Baird | Sound Supervisor |
| Richard Kitting | Additional Sound Re-Recording Mixer |
| Larry Barado | Special Effects Technician |
| David Nash | Special Effects Technician |
| Jake Whitney | Special Effects Technician |
| McMurphy Quito | Visual Effects |
| Shane Dufrene | Utility Stunts |
| Jeff Galpin | Stunts |
| Lex D. Geddings | Utility Stunts |
| Tony Lazzara | Stunts |
| Sam Medina | Stunts |
| Cory Parker | Set Dresser |
