 | Seth Rogen als Mac Radner |
 | Zac Efron als Teddy Sanders |
 | Rose Byrne als Kelly Radner |
 | Chloë Grace Moretz als Shelby |
 | Dave Franco als Pete |
 | Ike Barinholtz als Jimmy |
 | Lisa Kudrow als Dean Carol Gladstone |
 | Selena Gomez als Phi Lamda President |
 | Jerrod Carmichael als Garf |
 | Carla Gallo als Paula |
 | Kiersey Clemons als Beth |
 | Beanie Feldstein als Nora |
 | Hannibal Buress als Officer Watkins |
 | Christopher Mintz-Plasse als Scoonie |
 | Elise Vargas als Stella |
| Zoey Vargas als Stella |
 | Clara Mamet als Maranda |
 | Awkwafina als Christine |
 | John Early als Darren |
 | Johnny Pemberton als Frat President |
 | Kyle Mooney als R.A. |
 | Ian Gregg als Second Frat Guy |
 | Jacob Wysocki als Live Tinder Guy |
 | Liz Cackowski als Wendy the Realtor |
 | Kelsey Grammer als Shelby's Dad |
 | Sam Richardson als Eric Baiers |
 | Abbi Jacobson als Jessica Baiers |
 | Billy Eichner als Oliver Studebaker |
 | Brian Huskey als Bill Wazakowski |
 | Miles Armstrong als Rapper |
| Kemuel Crossty als Rapper |
| Cameron Hill als Rapper |
| Denryc Hill als Rapper |
| Brian K. Johnson als Rapper |
| Windsor Jones als Rapper |
| Harrison Thacker als Rapper |
 | Ciara Bravo als Sorority Girl |
| Nicholas Stoller | Director |
| Nicholas Stoller | Writer |
| Seth Rogen | Writer |
| Andrew J. Cohen | Writer |
| Evan Goldberg | Writer |
| Brendan O'Brien | Writer |
| Andrew J. Cohen | Characters |
| Zene Baker | Editor |
| Evan Goldberg | Producer |
| Tom Wolfe | Music Supervisor |
| Nathan Kahane | Executive Producer |
| Theresa Guleserian | Production Design |
| Brendan O'Brien | Characters |
| Ted Gidlow | Executive Producer |
| Andrew J. Cohen | Executive Producer |
| Brendan O'Brien | Executive Producer |
| Francine Maisler | Casting |
| Manish Raval | Music Supervisor |
| Leesa Evans | Costume Design |
| Seth Rogen | Producer |
| Michael Andrews | Original Music Composer |
| Kathy Driscoll-Mohler | Casting |
| Ted Gidlow | Unit Production Manager |
| James Weaver | Producer |
| Brandon Trost | Director of Photography |
| Joseph Drake | Executive Producer |
| Cate Bangs | Art Direction |
| Ryan Watson | Set Decoration |
| Maggie Fung | Makeup Department Head |
| Michael Babcock | Sound Re-Recording Mixer |
| Michael Babcock | Supervising Sound Editor |
| Jeff Sawyer | Sound Effects Editor |
| Randy Torres | Sound Effects Editor |
| Michael A. Webber | Editor |
| Erin Westerman | Co-Producer |
| Josh Fagen | Co-Producer |
| Kyle Hunter | Co-Producer |
| Ariel Shaffir | Co-Producer |
| Michael J. Moore | First Assistant Director |
| Matt Haggerty | Second Assistant Director |
| Jeffrey J. Dashnaw | Stunt Coordinator |
| Jamal Sims | Choreographer |
| Maria Blasucci | Associate Producer |
| Amanda Lund | Associate Producer |
| Douglas I. Schwartz | Associate Producer |
| Patricia Klawonn | Set Designer |
| John Thigpen | Set Designer |
| Heather Kane | On Set Dresser |
| Ellen Arden | Makeup Artist |
| Robert Satkovich | Makeup Artist |
| Colleen LaBaff | Hair Department Head |
| Alicia Accardo | Script Supervisor |
| Tony Lamberti | Sound Re-Recording Mixer |
| Doug Delaney | Digital Intermediate Colorist |
| Blake Hooks | Second Assistant "B" Camera |
