 | Bruce Willis als RJ (voice) |
 | Garry Shandling als Verne (voice) |
 | Steve Carell als Hammy (voice) |
 | Wanda Sykes als Stella (voice) |
 | William Shatner als Ozzie (voice) |
 | Nick Nolte als Vincent (voice) |
 | Thomas Haden Church als Dwayne (voice) |
 | Allison Janney als Gladys (voice) |
 | Eugene Levy als Lou (voice) |
 | Catherine O'Hara als Penny (voice) |
 | Avril Lavigne als Heather (voice) |
 | Omid Djalili als Tiger (voice) |
 | Sami Kirkpatrick als Bucky (voice) |
 | Shane Baumel als Spike (voice) |
 | Madison Davenport als Quillo (voice) |
 | Ariel Winter als (voice) |
 | Michaela Jill Murphy als (voice) |
 | Paul Butcher als Skeeter (voice) |
| Zoe Randol als Mackenzie (voice) |
 | Jessica DiCicco als Shelby (voice) |
 | Debra Wilson als Debbie (voice) |
| Sean Bishop als Police Officer (voice) |
 | Jeannie Elias als Janis (voice) |
| Kejon Kesse als Timmy (voice) |
| Sean Yazbeck als BBQ Barry (voice) |
 | Geoffrey Pomeroy als Ranger (voice) |
 | Joel McCrary als Dr. Dennis (voice) |
| Lee Bienstock als Lunch Table Larry (voice) |
 | Brian Stepanek als Nugent the Dog (voice) |
| Steve Alterman als (voice) |
| Erin Lander als (voice) |
 | Kirk Baily als (voice) |
| Jordan Orr als (voice) |
 | Michelle Ruff als (voice) |
 | Nicholas Guest als (voice) |
| Greyson Spann als (voice) |
| David Hiller als (voice) |
| April Lawrence als Navistar GPS System (voice) |
 | Bridget Hoffman als (voice) |
 | Marcelo Tubert als (voice) |
| Sandy Holt als (voice) |
| Talula Holt als (voice) |
| Pat Fry als TV Announcer (voice) (uncredited) |
| Len Blum | Screenplay |
| Lorne Cameron | Screenplay |
| David Hoselton | Screenplay |
| Karey Kirkpatrick | Screenplay |
| Michael Fry | Characters |
| Tom Lewis | Characters |
| Pat Sito | Art Department Manager |
| Steve Cunningham | Animation |
| Simon Otto | Art Department Manager |
| Emilio Ghorayeb | Animation |
| Steven E. Gordon | Storyboard |
| Lorne Balfe | Thanks |
| Stephen J. Eads | Thanks |
| Fern Lee | Thanks |
| Rob Letterman | Thanks |
| Cameron Stevning | Thanks |
| Stuart Sumida | Thanks |
| Chris Poche | Additional Dialogue |
| Eric Forsberg | Additional Dialogue |
| Mike de Seve | Script Consultant |
| Bonnie Arnold | Producer |
| Ellen Coss | Associate Producer |
| Jim Cox | Co-Executive Producer |
| Bill Damaschke | Executive Producer |
| Christian Kubsch | Producer |
| Rupert Gregson-Williams | Original Music Composer |
| John K. Carr | Editor |
| Leslee Feldman | Casting |
| Kathy Altieri | Production Design |
| Paul Shardlow | Art Direction |
| Jane Poole | Costume Design |
| Tony Sereno | Additional Sound Re-Recording Mixer |
| Darci Zalvin | Animation Supervisor |
| Kolja Erman | CGI Director |
| James Beshears | Post Production Supervisor |
| Ben H. Kwa | Software Engineer |
| Abhay Manusmare | Score Engineer |
| Rachel Bolt | Musician |
| James Hull | Animation |
| Morgan R. Kelly | Animation |
| Alessandro Carloni | Animation |
| Philip K. Livingston Jr. | Animation |
| Jennifer L. Hoskin | Actor's Assistant |
| Tiffany Moss | Actor's Assistant |
| Buck Lewis | Character Designer |
| Halli Cauthery | Additional Music |
| Tony Clarke | Additional Music |
| Gianni Aliotti | Compositors |
| Erik Mattson | CG Supervisor |
| Rupert Gregson-Williams | Orchestrator |
| Alastair King | Orchestrator |
| Vicki Hunter | Finance |
| Terri Anderson | Finance |
| Reuben Simon | Foley Editor |
| Buck Lewis | Lead Character Designer |
| Shaun Collaco | Lighting Artist |
| Michael Zavala | Modeling |
| Alan Meyerson | Scoring Mixer |
| Nicholas Bucknall | Musician |
| Jonathan Snowden | Musician |
| James Thatcher | Musician |
| Tom Boyd | Musician |
| Dan Newell | Musician |
| Bruce White | Musician |
| Mark Berrow | Musician |
| Angel G. Salinas | Production Coordinator |
| David Juan Bianchi | Production Coordinator |
| Wendy Berry Campbell | Production Coordinator |
| Kathy Cavaiola | Production Supervisor |
| Gary Rizzo | Sound Re-Recording Mixer |
| Laurence Cottle | Musician |
| Mike Chock | Sound Effects Editor |
| Steve Lee | Sound Effects Editor |
| John O'Sullivan | Systems Administrators & Support |
| Michael H. Lee | Visual Effects Technical Director |
| Patrick Marc Hanenberger | Visual Development |
| Damon Bard | Sculptor |
| Ariandy Chandra | Title Designer |
| Mark Fattibene | CG Supervisor |
| Joe Palrang | CG Supervisor |
| Bert Poole | CG Supervisor |
| Milton E. Rodriguez-Rios | CG Supervisor |
| Dave Walvoord | CG Supervisor |
| Hans Zimmer | Executive Music Producer |
| Mark Schoellkopf | Post Production Assistant |
| Barbara Ford | Post-Production Manager |
| Lori Korngiebel | Post Production Supervisor |
| Hernan Silberman | Software Engineer |
| Dave Burgess | Supervising Animator |
| Paul Chung | Supervising Animator |
| John Hill | Supervising Animator |
| Jason Reisig | Supervising Animator |
| William Salazar | Supervising Animator |
| Kristof Serrand | Supervising Animator |
| Gregory Brentin | Supervising Technical Director |
| Bart Feliciano | Systems Administrators & Support |
| Scott Kilty | Systems Administrators & Support |
| Derek Mann | Systems Administrators & Support |
| John R. Miller | Systems Administrators & Support |
| Stephen E. Ross | Systems Administrators & Support |
| Amanda Deering Jones | Script Coordinator |
| Joshua Pruett | Script Coordinator |
| Karl Armstrong | Assistant Editor |
| Alex McDonnell | Assistant Editor |
| Mary Blee | Associate Editor |
| Susan Fitzer | Associate Editor |
| Gina Gallo | Associate Editor |
| Mark A. Hester | Associate Editor |
| Terry Claborn | Color Timer |
| Maurissa Horwitz | First Assistant Editor |
| Mo Henry | Negative Cutter |
| Kevin Edwards | Lighting Artist |
| Lei Han | Lighting Artist |
| Amy Rae Jones | Lighting Artist |
| Christopher Lexington | Lighting Artist |
| Ozgur Ustundag | Lighting Artist |
| Liang-Yuan Wang | Lighting Artist |
| Matthieu Grospiron | Lighting Artist |
| Dennis Recchia | Lighting Artist |
| Celeste Leger | Casting Assistant |
| Kristen D. Chidel | Executive In Charge Of Production |
| Kristina Reed | Executive In Charge Of Production |
| Andrea McCarthy Paul | Production Accountant |
| Michael Lynn | Production Coordinator |
| Stephanie C. Lee | Production Coordinator |
| Malia P. Russell | Production Coordinator |
| Jeff Chasin | Production Coordinator |
| Christopher Leahy | Production Coordinator |
| Bruce Seifert | Production Manager |
| Larry Weisberg | Production Office Coordinator |
| Patrice Avery | Production Supervisor |
| Jennifer Dahlman | Production Supervisor |
| Alison Fedrick Donahue | Production Supervisor |
| Marny Nahrwold | Production Supervisor |
| Matt Pomeroy | Production Supervisor |
| Craig Rittenbaum | Production Supervisor |
| Bethany Wilksen | Production Supervisor |
| Caprice Ann Ridgeway | Researcher |
| Ray Felipe | Script Researcher |
| Mark Coffey | Assistant Sound Editor |
| Andy Sisul | Assistant Sound Editor |
| Josephine Nericcio | First Assistant Sound Editor |
| Dan O'Connell | Foley |
| Bob Newlan | Foley Editor |
| Rodrigo Ortiz-Parraga | Foley Editor |
| Slamm Andrews | Music Editor |
| Chris Douridas | Music Supervisor |
| George Doering | Musician |
| Frank Wolf | Scoring Mixer |
| Mark Binder | Sound Designer |
| David A. Whittaker | Sound Effects Editor |
| Randy Thom | Sound Mixer |
| Ronald G. Roumas | Sound Recordist |
| Richard L. Anderson | Supervising Sound Editor |
| Thomas Jones | Supervising Sound Editor |
| Christopher Lee Capel | Animation |
| Beau DeSilva | Animation |
| Chris Bancroft | Animation |
| Jeremy Bernstein | Animation |
| Arnaud Berthier | Animation |
| Scott Claus | Animation |
| Donnachada Daly | Animation |
| Eric Daniels | Animation |
| Eric Deuel | Animation |
| Bill Diaz | Animation |
| Roberto Espanto Domingo | Animation |
| Thomas Estrada | Animation |
| Raffaella Filipponi | Animation |
| Antony Gray | Animation |
| Willy Harber | Animation |
| Tim Ingersoll | Animation |
| Jeffrey Joe | Animation |
| Aaron Kirby | Animation |
| Chris Kirshbaum | Animation |
| Heather Knight | Animation |
| Kevin Koch | Animation |
| Marek Kochout | Animation |
| Serguei Kouchnerov | Animation |
| Kevin MacLean | Animation |
| Sean Mahoney | Animation |
| Sean McLaughlin | Animation |
| Claire Morrissey | Animation |
| Luci Napier | Animation |
| Fredrik Nilsson | Animation |
| Ben Rush | Animation |
| Jason Schleifer | Animation |
| Sean Sexton | Animation |
| Theodore Anthony Lee Ty | Animation |
| Jim Van der Keyl | Animation |
| Chris Wahl | Animation |
| Scott Wright | Animation |
| Kathy Zielinski | Animation |
| Jakob Hjort Jensen | Character Designer |
| Nico Marlet | Character Designer |
| Tony Siruno | Character Designer |
| Jaewon Lee | Modeling |
| Steve McGrath | Modeling |
| Charlie Ramos | Modeling |
| John P. Rand | Modeling |
| Jeff Wagner | Modeling |
| Joshua West | Modeling |
| Tony K. Williams | Modeling |
| Nadja Bonacina | Modeling |
| Hyun Huh | Modeling |
| Max Boas | Visual Development |
| Paul Duncan | Visual Development |
| Ron Lukas | Visual Development |
| Ritchie Sacilioc | Visual Development |
| David Caeiro Cebrián | Visual Effects |
| William Opdyke | Visual Effects |
| Paul Rademacher | Visual Effects |
| Kevin Vassey | Visual Effects |
| Andy Chen | VFX Artist |
| Karen Smith | VFX Artist |
| Craig Ring | Visual Effects Supervisor |
| Juan Peralta | Sound Mix Technician |
| Brandon Proctor | Sound Mix Technician |
| Wayne Hellinger | Post Production Coordinator |
| Melchior Zwyer | Props |
| Lok Ming Hwa | Layout Supervisor |
| Tom Kramer | Additional Music |
| Alessandro Carloni | Storyboard Artist |
| Derek Casari | ADR Engineer |
| Michael Miller | ADR Mixer |
| Courtney Bishop | ADR Recordist |
| John T. Cucci | Foley Artist |
| James Ashwill | Foley Mixer |
| Dan A. Walker | Animation Technical Director |
| Zahida Bacchus | Digital Intermediate Producer |
| Rupert Gregson-Williams | Conductor |
| Julie Imboden Keel | Music Coordinator |
| Mary M. Quinn | Administrative Assistant |
| Jim Mainard | Head of Research |
| Jeff Snow | Head of Story |
| Max Boas | Matte Painter |
| Brendan O'Connor | Production Assistant |
| Kristen D. Chidel | Production Executive |
| David Soren | Story Artist |
| Joshua Pruett | Story Coordinator |
| Damon O'Beirne | Cinematography |
| Damon O'Beirne | Head of Layout |
| Christian Schellewald | Art Direction |
| Karey Kirkpatrick | Director |
| Tim Johnson | Director |
| Ben Folds | Songs |
