 | Eddie Murphy als Det. Axel Foley |
 | Judge Reinhold als Det. Sgt. Billy Rosewood |
 | Hector Elizondo als Det. Jon Flint |
 | Timothy Carhart als Ellis Dewald |
 | John Saxon als Orrin Sanderson |
 | Theresa Randle als Janice |
 | Stephen McHattie als Agent Steve Fulbright |
 | Alan Young als Uncle Dave Thornton |
 | Gilbert R. Hill als Insp. Douglas Todd |
 | Bronson Pinchot als Serge |
 | Jon Tenney als Levine |
 | Joey Travolta als Giolito |
 | Eugene Collier als Leppert |
 | Jimmy Ortega als Rondell |
 | Ousaun Elam als Pederson |
 | Ray Lykins als Nixon |
 | Tim Gilbert als McKee |
 | Rick Avery als Cline |
| Dick Purtan als Detroit Disc Jockey |
| Fred Asparagus als Bobby |
 | Louis Lombardi als Snake |
 | Lindsey Ginter als Holloway |
 | Michael Bowen als Fletch |
| David Parry als Taddeo |
 | Al Green als Minister |
 | Hattie Winston als Mrs. Todd |
 | Tracy Melchior als Ticket Booth Girl |
 | Gregory McKinney als Kimbrough |
 | Forry Smith als Rondy |
 | Dan Martin als Cooper |
 | Steven Banks als Spider Ride Operator |
 | George Lucas als Disappointed Man |
| Christina Venuti als Disappointed Girl |
 | Jonathan Hernandez als Scared Boy |
| Christy Alvarez als Scared Girl |
 | Yareli Arizmendi als Scared Kids' Mom |
 | Jeannie Epper als Spider Rider |
| Kurtis Epper als Spider Rider |
| Bill Taylor als Spider Rider |
| Neva Sosna als Spider Rider |
 | Nichole McAuley als Spider Rider |
| Jerra Stewart als Spider Rider |
| Patty Raya als Spider Rider |
 | Meadow Williams als Spider Rider |
| Aileen Acain als Waitress (Lily) |
 | Martha Coolidge als Security Woman |
 | Symba als Annihilator Girl |
 | Julie Strain als Annihilator Girl |
| Heather Elizabeth Parkhurst als Annihilator Girl |
 | George Schaefer als Mike |
 | Joe Dante als Jailer |
 | Curtis Williams als Little Kid (loves Oki-Doki) |
 | Theodore Borders als Big Kid |
 | Helen Martin als Grandma |
 | Albie Selznick als Technician |
 | Charles Rahi Chun als Technician |
| Roger E. Reid als Man on Phone |
| Royce Reid als Feisty Kid |
| Hector Correa als Man with Video Camera |
 | Elaine Kagan als Sanderson's Secretary |
 | Tino Insana als Burly Cop |
| John Rubinow als Doctor |
| Hank McGill als Paramedic |
| Cherilyn Shea als Girl at Corner |
 | Peter Medak als Man at Corner |
 | Arthur Hiller als Bar Patron |
 | Ray Harryhausen als Bar Patron |
 | Robert B. Sherman als Bar Patron |
| Eugene Elman als Bartender |
| Jerry Dunphy als Newscaster |
 | Barbet Schroeder als Man in Porsche |
| Philip Levien als Serge's Assistant (Donny) |
 | John Singleton als Fireman |
| Lisa Allen als Prescott Pig |
| Julie Dolan als Prescott Pig |
| Christian Heath als Oki-Doki |
| Patricia Quinn als Oki-Doki |
 | Sean Spence als Rufus Rabbit |
| James MacKinnon als Rufus Rabbit |
| Jennifer Cobb als Meyer Lion |
| Lynn Walsh als Meyer Lion |
| Susan Gayle als Kopy Kat |
| Devin McRae als Kopy Kat |
| Wendy Harpenau als Liddle Bear |
| Felicia Wong als Liddle Bear |
| Marlene Hoffmann als Big Bear |
| Wanda Welch als Big Bear |
| Liza Macawili als Floyd Fox |
 | Robin Shelby als Floyd Fox |
| Dave Myers als Tippy Turtle |
| Matt Myers als Tippy Turtle |
 | Nick Hermz als Tadross Gorilla |
| Tim Shuster als Tadross Gorilla |
 | Anthony G. Schmidt als Horvath (uncredited) |
| Kiante Elam als Car Mechanic (uncredited) |
 | Al Leong als Car Mechanic (uncredited) |
 | Thomas Rosales Jr. als Car Mechanic (uncredited) |
| Ryal Haakenson als Hotel Doorman (uncredited) |
 | Richard M. Sherman als Wonderworld Bandleader (scenes deleted) |
| Aliza Washabaugh als OR Nurse (uncredited) |
 | Lynnanne Zager als Beverly Hills Police Station Computer (voice) (uncredited) |
 | Bob Minor als Security Guard in Printing Room (uncredited) |
| John Landis | Director |
| Mace Neufeld | Producer |
| Robert Rehme | Producer |
| Nile Rodgers | Original Music Composer |
| Mac Ahlberg | Director of Photography |
| Dale Beldin | Editor |
| Jackie Burch | Casting |
| Michael Seymour | Production Design |
| Mark Lipsky | Executive Producer |
| Danilo Bach | Characters |
| Daniel Petrie Jr. | Characters |
| Leslie Belzberg | Co-Producer |
| Ray Murphy Jr. | Associate Producer |
| Marty Hornstein | Unit Production Manager |
| Arthur Anderson | First Assistant Director |
| Albert Cho | Second Assistant Director |
| Thomas Johnston | Script Supervisor |
| Rick Avery | Stunt Coordinator |
| Thomas P. Wilkins | Art Direction |
| Masako Masuda | Assistant Art Director |
| Ricardo F. Delgado | Production Illustrator |
| Marvin March | Set Decoration |
| Daril Alder | Leadman |
| Roy Bean | Video Assist Operator |
| Theresa Repola Mohammed | Negative Cutter |
| Phil Hetos | Color Timer |
| Kathy Nelson | Music Supervisor |
| William Jennings | Second Second Assistant Director |
| Cary Fisher | "A" Camera Operator |
| David Boyd | "B" Camera Operator |
| Baird Steptoe | First Assistant "B" Camera |
| A. Anthony Cappello | Second Assistant "B" Camera |
| Gregory Lundsgaard | Steadicam Operator |
| Sue Moore | Costume Supervisor |
| David Rawley | Key Costumer |
| Silvio Scarano | Key Costumer |
| Dick Kyker | Property Master |
| Robert Scott Kyker | Assistant Property Master |
| Joseph Geisinger | Sound Mixer |
| Craig Woods | Boom Operator |
| Mark Steinbeck | Cableman |
| D.J. Plumb | Hairstylist |
| Ora Green | Hairstylist |
| Marietta Carter-Narcisse | Makeup Supervisor |
| Geri B. Oppenheim | Key Makeup Artist |
| Toy Van Lierop | Makeup Artist |
| Coree Lear | Makeup Artist |
| Dean Sadler | Makeup Artist |
| Donald L. Hartley | Dolly Grip |
| Lonnie Stewart | Dolly Grip |
| Gerald Boatright | Chief Lighting Technician |
| Walter Nichols | Assistant Chief Lighting Technician |
| Steve Boyum | Second Unit Director |
| Jon G. Belyeu | Special Effects Coordinator |
| Smith Wordes | Choreographer |
| Paula Benson-Himes | Production Office Coordinator |
| Lou Phillips | Production Accountant |
| Gail Goldberg | Casting Assistant |
| Ron Windred | Location Manager |
| Patrick Mignano | Assistant Location Manager |
| Bruce W. Talamon | Still Photographer |
| Peter Evangelatos | Craft Service |
| Robert Bonino | Construction Coordinator |
| Wayne Nelson | Transportation Coordinator |
| Wayne Williams | Transportation Captain |
| Fulton 'Greg' Gilson | Transportation Co-Captain |
| Richard C. Franklin | Supervising Sound Editor |
| Doug Jackson | Supervising Sound Editor |
| Kerry Dean Williams | Sound Effects Editor |
| William Jacobs | Sound Effects Editor |
| Jeff Bushelman | Foley Editor |
| Joseph A. Ippolito | Supervising Dialogue Editor |
| Kevin Hearst | Dialogue Editor |
| Gloria D'Alessandro | Dialogue Editor |
| James Beshears | ADR Supervisor |
| Stephen Janisz | ADR Editor |
| Ken Dufva | Foley Artist |
| David Lee Fein | Foley Artist |
| Eric Gotthelf | Foley Mixer |
| Bob Baron | ADR Mixer |
| Paul Massey | Sound Re-Recording Mixer |
| Scott Millan | Sound Re-Recording Mixer |
| Steve Pederson | Sound Re-Recording Mixer |
| Jeff Carson | Supervising Music Editor |
| Tom Villano | Music Editor |
| Steven Lambert | Stunts |
| Jeannie Epper | Stunts |
| Rosine 'Ace' Hatem | Stunts |
| Eurlyne Epper | Stunts |
| Charlie Picerni | Stunts |
| Joni Avery | Stunts |
| Spiro Razatos | Stunts |
| Doug Coleman | Stunts |
| Gregory J. Barnett | Stunts |
| Keith Woulard | Stunts |
| Steven E. de Souza | Screenplay |
| Catherine Adair | Costume Designer |
| Alex Leyton | First Assistant "A" Camera |
| Thomas Vandermillen | Second Assistant "A" Camera |
| Brent Lon Hershman | Camera Loader |
| Mitchell Ray Kenney | Set Costumer |
| Kelly Porter (costumer) | Set Costumer |
| Fetteroff Colen | Set Costumer |
| Kelly Kimball | Costume Designer |
| Karen M. Davis | Costumer |
| Christine McKenzie | Graphic Designer |
| Ann-Giselle Spiegler | Art Department Coordinator |
| Aaron M. Albucher | Art Department Production Assistant |
| Caroline Perzan | Set Decoration Buyer |
| James Buckley | Props |
| Kevin Chambers | Props |
| Richard Chirco | Props |
| Michael P. Hunter | Props |
| David Napoli | Props |
| Tamara Clinard | On Set Dresser |
| Eric Bilson | Propmaker |
| Alex Barraza | First Company Grip |
| Steele Hunter | Second Company Grip |
| Brian Smith | Second Company Grip |
| John Palka | Rigging Grip |
| Tom Lamont | Rigging Grip |
| John Farmer | Grip |
| Joe Kraft | Grip |
| Robert Sharp | Grip |
| Donald L. Hartley | Grip |
| Christopher Whitman | Assistant Chief Lighting Technician |
| William Aldridge | Special Effects |
| Chris Burton | Special Effects |
| Manuel S. Epstein | Special Effects |
| Chuck Hessey | Special Effects |
| Harold Selig | Special Effects |
| Syd Dutton | Visual Effects |
| Bill Taylor | Visual Effects |
| Steven Chuck | Production Assistant |
| Scott Eberlein | Production Assistant |
| Derek Johansen | Production Assistant |
| Gary S. Lipsky | Production Assistant |
| Matt Luber | Production Assistant |
| Darryl Pryor | Production Assistant |
| Wayne Witherspoon | Production Assistant |
| Charisse M. Hewitt | Actor's Assistant |
| Kimberly Tangorra | Executive Producer's Assistant |
| Dan March | Production Assistant |
| Frank LaTorre | Production Assistant |
| Nile Rodgers | Theme Song Performance |
| Bonnie Haner | Producer's Assistant |
| Heather Upjohn | Producer's Assistant |
| Kathy Day | Producer's Assistant |
| Laurie Woolery | Actor's Assistant |
| Laura Folger | Extras Casting |
| Susan Nowak | Unit Publicist |
| Anthony Kerum | Catering |
| Neil Saiger | Construction Foreman |
| Todd Young | Construction Foreman |
| Christopher S. Baird | First Assistant Editor |
| Phyllis Housen | Assistant Editor |
| Jeffrey Harlacker | Assistant Editor |
| Steve Mann | Foley Editor |
| Nick Perito | Conductor |
| Mark McKenzie | Orchestrator |
| Ken Kushnick | Music Consultant |
| David Passick | Music Consultant |
| Eric Chambers | Stunts |
