 | Paul Mercier als Leon S. Kennedy (voice) |
 | Alyson Court als Claire Redfield (voice) |
 | Laura Bailey als Angela Miller (voice) |
 | Roger Craig Smith als Curtis Miller (voice) |
 | Crispin Freeman als Frederic Downing (voice) |
 | Michael Sorich als Senator Ron Davis (voice) |
 | Salli Saffioti als Ingrid Hunnigan (voice) |
 | Michelle Ruff als Rani Chawla (voice) |
 | Mary Elizabeth McGlynn als Rani's aunt (voice) |
 | Steve Blum als Greg Glenn (voice) |
 | Michael McConnohie als WilPharma CEO (voice) |
 | Kirk Thornton als U.S. President (voice) |
 | Cindy Robinson als Various (voice) |
 | Dave Wittenberg als Various (voice) |
 | Kari Wahlgren als Various (voice) |
 | Kyle Hebert als Various (voice) |
 | Barbara Goodson als Various (voice) |
 | Keith Silverstein als Various (voice) |
 | Yuri Lowenthal als Various (voice) |
 | Megan Hollingshead als Various (voice) |
 | Skip Stellrecht als Various (voice) |
 | Troy Baker als Various (voice) |
 | Karen Strassman als Various (voice) |
 | JB Blanc als Various (voice) |
 | Johnny Yong Bosch als Various (voice) |
 | Derek Mears als Greg Glenn / G-Curtis (motion capture) |
| Makoto Kamiya | Director |
| Shoutarou Suga | Screenplay |
| Haruhiro Tsujimoto | Executive Producer |
| Hidenori Ueki | Co-Producer |
| Hiroyuki Kobayashi | Producer |
| Koji Kasamatsu | Sound Designer |
| Yota Tsuruoka | Sound Director |
| Shinji Mikami | Video Game |
| Tokuro Fujiwara | Video Game |
| Kenichi Iwao | Video Game |
| Takahiro Arimitsu | Video Game |
| Hiroyuki Kobayashi | Story |
| Yoshiaki Hirabayashi | Story |
| Father | Story Editor |
| Scott Dolph | Associate Producer |
| Daisuke Gomi | Associate Producer |
| Keiji Inafune | Executive Producer |
| Seiji Iseda | Producer |
| Aki Kiuchi | Associate Producer |
| Taro Morishima | Producer |
| Ivan C. Shih | Executive Producer |
| Masao Takiyama | Executive Producer |
| Toshi Tokumaru | Co-Executive Producer |
| Mareo Yamada | Associate Producer |
| Tetsuya Takahashi | Original Music Composer |
| Ryuji Miyajima | Editor |
| Shiho Tamura | Production Design |
| Kuniko Hôjô | Costume Design |
| Alena Fang | Production Manager |
| Kumiko Oguri | Production Manager |
| Sareana Sun | Production Manager |
| Kentaro Fujisawa | Second Assistant Director |
| Gaku Nagao | First Assistant Director |
| Takumi Sakura | Prop Designer |
| Nobuhito Sue | Layout |
| Les Claypool III | Dialogue Editor |
| Yoshiki Matsunaga | Sound Editor |
| Yoshimi Sugiyama | Production Manager |
| Hiroki Ando | Compositor |
| Kazuhiro Asakawa | Compositor |
| Wu Bin | VFX Artist |
| Zhang Bei | Lighting Artist |
| Stacy Chang | Modeling |
| Peng Chao | Lighting Artist |
| Hsin-Che Chen | Modeling |
| Soyoung Cheng | Modeling |
| Chaucer Chiu | Modeling |
| Liu Dexin | Lighting Artist |
| Atsushi Doi | CGI Director |
| Nobutaka Emoto | Compositor |
| Naoyuki Fujii | Compositor |
| Le Gao | Lighting Artist |
| Tsubasa Harikae | Compositing Lead |
| Yifang He | Lighting Artist |
| Yoshiaki Hirabayashi | Modelling Supervisor |
| Zhang Hongkun | Lighting Artist |
| Ni Hongtao | Animation |
| Satoshi Hakuzen | Stunts |
| Nobuhiro Inohara | Stunts |
| Jersey Maki Itosu | Stunts |
| Naohiro Kawamoto | Stunts |
| Hiroyuki Yoshida | Action Director |
| Hiroki Ando | Animation |
| Kazuhiro Asakawa | Character Designer |
| Michelle Ladd | Casting Producer |
| Thom Williams | Casting Producer |
| Hiroyuki Yoshida | Casting Producer |
| Yuuki Hashimoto | Post Production Producer |
| Narihiko Kôno | Assistant Editor |
| Father | Script Supervisor |
| Shinji Nishikawa | Storyboard Artist |
| Kiyoshi Okuyama | Storyboard Artist |
| Hiromitsu Soma | Storyboard Artist |
| Koji Kawamoto | Stunts |
| Shinji Mikami | Original Story |
