 | Johnny Depp als George Jung |
 | Penélope Cruz als Mirtha Jung |
 | Franka Potente als Barbara Buckley |
 | Rachel Griffiths als Ermine Jung |
 | Paul Reubens als Derek Foreal |
 | Jordi Mollà als Diego Delgado |
 | Cliff Curtis als Pablo Escobar |
 | Max Perlich als Kevin Dulli |
 | Miguel Sandoval als Augusto Oliveras |
 | Ethan Suplee als Tuna |
 | Ray Liotta als Fred Jung |
 | Kevin Gage als Leon Minghella |
 | Tony Amendola als Sanchez |
 | Jesse James als Young George |
 | Emma Roberts als Young Kristina Jung |
 | Dan Ferro als Cesar Toban |
 | Bobcat Goldthwait als Mr. T |
 | Miguel Pérez als Alessandro |
 | Michael Tucci als Dr. Bay |
 | Monet Mazur als Maria |
 | Lola Glaudini als Rada |
 | Jennifer Gimenez als Inez |
 | Jaime King als Kristina Jung |
| Charles Noland als Jack Stevens |
| Pamela Abdy als Beach Woman #3 |
 | John Harrington Bland als FBI Waiter #1 |
 | Jimmy Burke als FBI Waiter #4 |
 | Brantley Bush als FBI Waiter #3 |
 | Kevin Chapman als DEA Eastham |
 | Ted Demme als Archie Sigmond |
 | Daniel Escobar als Emilio Ochoa |
| Tracy Falco als Beach Woman #2 |
| Vanessa Grayson als Stewardess #3 |
| Elif Guertin als Stewardess #2 |
| Faith Hoover als Stewardess #6 |
| Kristina Jung als Clerk |
 | Dorothy Lyman als Judge (Chicago) |
 | Genevieve Maylam als Beach Woman #1 |
| Kathleen Mullan als Beach Woman #5 |
 | Meriah Nelson als Stewardess #4 |
| Sophie Tsimel als Beach Woman #4 |
| The Dawk als Guard (Visit Area #2) |
| Crystal Erickson als Stewardess #1 |
| Jean-Carlos Felix als Prison Guard (Warden's Office) |
| Lazaro Galarraga als Band Singer |
 | Brian Goodman als Guard Gus |
| Josh Herman als Detective #1 |
 | Brad Hunt als GG |
 | Patrick Husted als Bank Manager (Mass.) |
| Ralph Kampshoff als Guard (Visit Area ä1) |
 | Ajgie Kirkland als James Trout |
| Skip O'Brien als Customs Agent |
 | Richard LaGravenese als Detective #2 |
 | Roberto Lopez als Guard (Danbury) |
| Lydell M. Cheshier als Inmate #3 |
| Jodie Mann als Nurse (Cape Cod) |
| Charles Martiniz als Bank Employee |
 | Gonzalo Menendez als Ramon Ochoa |
 | Mauricio Mendoza als Benny |
| Carlos Mendoza als Tony |
| Alan James Morgan als Young Tuna |
 | Randy Mulkey als Employee #1 |
 | Tony Perez als Bank President |
| Jack Polick als Ben |
 | Michael Ralph als Inmate #2 |
| Raoul N. Rizik als Rafael Ojeda |
| Matt Robinson als Inmate #1 |
 | Elizabeth Rodriguez als Martha Oliveras |
 | Bert Rosario als Bank President (Panama) |
| Leslie Schirrmacher als Stewardess #5 |
| Dale Snowberger als FBI Waiter #2 |
 | Julia Vera als Clara Blanca |
| Santiago Verdu als Juan Carlos |
| Pamela Walker als FBI Waiter #5 |
| Twyla Banks als Inmate's Daughter (uncredited) |
 | Greg Bronson als Prison Inmate (uncredited) |
 | Nick Cassavetes als Man in Derek's Salon (uncredited) |
| Janine Foster als Flight Attendant (uncredited) |
 | Jo Price als Business Woman (uncredited) |
 | Anna de Cardi als Friend at Pool Party (uncredited) |
| Avy Kaufman | Casting |
| Graeme Revell | Original Music Composer |
| David Ensley | Art Direction |
| Georgia Kacandes | Executive Producer |
| Joel Stillerman | Producer |
| Ellen Kuras | Director of Photography |
| Michael Z. Hanan | Production Design |
| Nick Cassavetes | Screenplay |
| Denis Leary | Producer |
| Kevin Tent | Editor |
| Michael De Luca | Executive Producer |
| David McKenna | Screenplay |
| Ted Demme | Director |
| Ted Demme | Producer |
| Jose Ludlow | Line Producer |
| Ve Neill | Makeup Artist |
| Tomáš Krejčí | Producer |
| Bruce Porter | Book |
| Douglas A. Mowat | Set Decoration |
| Amanda Scheer-Demme | Music Supervisor |
| Michael Keller | Sound Re-Recording Mixer |
| Hillary Sherman | Associate Producer |
| Lorey Sebastian | Still Photographer |
| Victor Ray Ennis | Supervising Sound Editor |
| Susan McNamara | Associate Producer |
| Susan McNamara | Production Supervisor |
| Tracy Falco | Associate Producer |
| Whitney James | Makeup Department Head |
| Patrick Cyccone Jr. | Sound Re-Recording Mixer |
| Cheree Welsh | Art Department Coordinator |
| Mark P. Stoeckinger | Supervising Sound Editor |
| Keenan Wyatt | Boom Operator |
| Richard Ford | Music Editor |
| Donna O'Neal | Set Costumer |
| Mark Bridges | Costume Design |
| Pamela Alch | Script Supervisor |
| Richard Dwan Jr. | Dialogue Editor |
| Glenn T. Morgan | Dialogue Editor |
| Kristina Jung | Thanks |
| Martin Scorsese | Thanks |
| Joni Avery | Stunts |
| Anita Hart | Stunt Double |
| Anita Hart | Stunts |
| Rick Avery | Stunt Coordinator |
| Georgia Kacandes | Unit Production Manager |
| Nicholas Mastandrea | First Assistant Director |
| Rosemary C. Cremona | Second Assistant Director |
| Brian Avery | Stunts |
| Cameron Croughwell | Stunts |
| Danny Wynands | Stunts |
| Chris Howell | Stunts |
| Carla Fry | Executive In Charge Of Production |
| Leon Dudevoir | Production Executive |
| Jody Levin | Executive In Charge Of Post Production |
| Rick Reynolds | Post Production Supervisor |
| Kevin Yagher | Makeup Designer |
| Susan McNamara | Executive Producer |
| Daniel R. Jennings | Assistant Art Director |
| Maria Baker | Set Designer |
| Bill Taliaferro | Set Designer |
| Adam Khalid | Art Department Assistant |
| Amiee Clark | Art Department Assistant |
| Timothy Braniff | Storyboard Artist |
| Karin L. McGaughey | Assistant Set Decoration |
| Scott Bobbitt | Leadman |
| Eric Ramirez | Leadman |
| Cheryl Gould Strang | Set Dresser |
| Jeff Damal | Set Dresser |
| Cynthia C. Rebman | Set Dresser |
| Andrew Rowlands | "A" Camera Operator |
| Andrew Rowlands | Steadicam Operator |
| Baird Steptoe | Focus Puller |
| Baird Steptoe | First Assistant "A" Camera |
| John Young | Second Assistant "A" Camera |
| Roger Wall | Camera Loader |
| Sandi Sissel | "B" Camera Operator |
| Henry Tirl | "B" Camera Operator |
| Henry Tirl | Steadicam Operator |
| Mark Santoni | First Assistant "B" Camera |
| Camille Freer | Second Assistant "B" Camera |
| Allan Byer | Sound Mixer |
| Tim Peyton | Utility Sound |
| Karen Eisenstadt | Production Accountant |
| Judy Blinick | First Assistant Accountant |
| Cathy Marshall-Hart | Payroll Accountant |
| Steven J. Reynolds | Assistant Accountant |
| Christa Vausbinder | Production Coordinator |
| John Burton West | Assistant Production Coordinator |
| Melissa Kinnicutt | Assistant Production Coordinator |
| Maria Mantia | Second Second Assistant Director |
| John C. Nadeau | Gaffer |
| Simone Perusse | Best Boy Electric |
| Gustavo Oliva | Rigging Gaffer |
| Brandon Ainsworth | Rigging Grip |
| Steve Kagan | Rigging Grip |
| John Janusek | Key Grip |
| John P. Shine | Best Boy Grip |
| Bryan Ashford | Dolly Grip |
| John Beran | Grip |
| Alex Klabukov | Grip |
| Rob J. Greenlea | Grip |
| Al Ambrosio | Grip |
| Jeff Kluttz | Key Rigging Grip |
| Don Telles | Rigging Grip |
| Maureen Farley | Property Master |
| Merdyce McClaran | Assistant Property Master |
| Kim Larsen-Santini | Props |
| Tom Dailey | First Assistant Editor |
| Danya Joseph | Assistant Editor |
| Mark Scovil | Assistant Editor |
| Buck Damon | Music Supervisor |
| Alan Rankin | Sound Effects Editor |
| Gary Mundheim | Foley Editor |
| Philip A. Hess | Foley Editor |
| Eric Flickinger | Sound Recordist |
| James Moriana | Foley Artist |
| Jeffrey Wilhoit | Foley Artist |
| Greg Zimmerman | Foley Recordist |
| Nerses Gezalyan | Foley Mixer |
| Ron Bedrosian | ADR Mixer |
| Brian Basham | ADR Recordist |
| Barbara Harris | ADR Voice Casting |
| Steve A. Hagberg | Construction Coordinator |
| Steve Borgese | Greensman |
| Desne J. Holland | Key Makeup Artist |
| Jamie Kelman | Key Makeup Artist |
| Martin Samuel | Hair Supervisor |
| Rita Troy | Key Hair Stylist |
| Karl Wesson | Key Hair Stylist |
| Candace Neal | Hairstylist |
| Cha Blevins | Costume Supervisor |
| Lisa Tomczeszyn | Assistant Costume Designer |
| Steve Constancio | Set Costumer |
| Jenny Eagan | Costumer |
| Bridgitte Ferry | Costumer |
| Guy Miracle | Costumer |
| Charmaine Nash Simmons | Costumer |
| Pablo Nantas | Tailor |
| Mike Fantasia | Location Manager |
| Fermin Davalos | Assistant Location Manager |
| Steven S. Lee | Assistant Location Manager |
| Peter Costelli | Assistant Location Manager |
| Donny Martino | Location Assistant |
| Paul Prokop | Production Controller |
| Emily Glatter | Production Coordinator |
| Lisa Behlendorf | Post Production Accountant |
| Beth Bowling | Casting Assistant |
| Rich King | Extras Casting |
| Andrea McBride | Extras Casting Assistant |
| Ron Bolanowski | Special Effects Coordinator |
| Robert Bolanowski | Special Effects |
| Michael Duenas | Special Effects |
| David Fulton | Unit Publicist |
| Jeffrey D. Stevens | Set Medic |
| Jessica Drake | Dialogue Coach |
| Nick Mestrundrea | Craft Service |
| Randy White | Transportation Coordinator |
| Cesar Angobaldo | Transportation Captain |
| Tim Simonec | Conductor |
| Tim Simonec | Orchestrator |
