 | Heath Ledger als Ennis Del Mar |
 | Jake Gyllenhaal als Jack Twist |
 | Michelle Williams als Alma Beers |
 | Anne Hathaway als Lureen Newsome |
 | Randy Quaid als Joe Aguirre |
 | Linda Cardellini als Cassie Cartwright |
 | Anna Faris als Lashawn Malone |
 | David Harbour als Randall Malone |
 | Roberta Maxwell als Mrs. Twist |
 | Kate Mara als Alma Del Mar Jr. (age 19) |
 | Peter McRobbie als John Twist |
 | Graham Beckel als L.D. Newsome |
 | Mary Liboiron als Fayette Newsome |
 | Scott Michael Campbell als Monroe |
 | Marty Antonini als Timmy |
 | David Trimble als Basque |
| Larry Reese als Jolly Minister |
| Valerie Planche als Waitress |
| Lachlan Mackintosh als Chilean Sheepherder #2 |
 | Tom Carey als Rodeo Clown |
| Don Bland als Biker #1 |
 | Steven Cree Molison als Biker #2 |
| Duval Lang als Announcer |
| Dan McDougall als Bartender #1 |
 | Dean Barrett als Bartender #2 |
| Kade Phillips als Ennis Del Mar (age 9) |
| Steffen Cole Moser als K.E. Del Mar (age 11) |
| Cheyenne Hill als Alma Del Mar Jr. (age 13) |
| Cayla Wolever als Jenny Del Mar (age 11) |
| Sarah Hyslop als Alma Del Mar Jr. (age 9-12) |
| Jacey Kenny als Jenny Del Mar (age 7-8) |
| Keanna Dubé als Alma Del Mar Jr. (age 5) |
| Brooklynn Proulx als Jenny Del Mar (age 4) |
| Hannah Stewart als Alma Jr. (age 3) |
 | Jake Church als Bobby Twist (age 10) |
| James Baker als Farmer #1 |
| Pete Seadon als Farmer #2 |
 | Jerry Callaghan als Judge |
| Ken Zilka als Roughneck #1 |
 | John Tench als Roughneck #2 |
| Will Martin als Carl |
| Gary Lauder als Killer Mechanic |
 | Christian Fraser als Grease Monkey |
| Cam Sutherland als Assailant |
 | Barb Mitchell als Western Dancer (uncredited) |
 | Rodrigo Prieto als Young Mexican (uncredited) |
| Ken Roberts als Signal Bartender (uncredited) |
| Kailin See als Hippy Girl (uncredited) |
 | Jayson Therrien als Bar Patron (uncredited) |
 | Erika Walter als Waitress #2 (uncredited) |
| Victor Reyes als Chilean Sheepherder #1 |
| Ang Lee | Director |
| Diana Ossana | Producer |
| James Schamus | Producer |
| Annie Proulx | Novel |
| Larry McMurtry | Screenplay |
| Diana Ossana | Screenplay |
| Gustavo Santaolalla | Original Music Composer |
| Rodrigo Prieto | Director of Photography |
| Geraldine Peroni | Editor |
| Dylan Tichenor | Editor |
| Avy Kaufman | Casting |
| Judy Becker | Production Design |
| Laura Ballinger | Art Direction |
| Tracey Baryski | Art Direction |
| Patricia Cuccia | Set Decoration |
| Catherine Davis | Set Decoration |
| Marit Allen | Costume Design |
| Penny Thompson | Hairstylist |
| Manlio Rocchetti | Makeup Department Head |
| Linda Melazzo | Makeup Artist |
| Karen Bédard | Script Supervisor |
| David Linck | Unit Publicist |
| Kathy Nelson | Music Supervisor |
| Annette Kudrak | Music Editor |
| Anibal Kerpel | Music Editor |
| Kimberly French | Still Photographer |
| Damon Moreau | Steadicam Operator |
| Christopher Porter | Gaffer |
| Christopher G. Sprague | Gaffer |
| Gordon Schmidt | Rigging Gaffer |
| Kirk Jarrett | Stunt Coordinator |
| Kelly Fraser | Costume Supervisor |
| Philip Stockton | Supervising Sound Editor |
| Peter Melnychuk | Boom Operator |
| Jürgen Lutze | Construction Coordinator |
| Scott Ferguson | Unit Production Manager |
| Tom Benz | Unit Production Manager |
| Michael Hausman | First Assistant Director |
| Michael Hausman | Executive Producer |
| Michael Costigan | Executive Producer |
| Larry McMurtry | Executive Producer |
| Bill Pohlad | Executive Producer |
| Scott Ferguson | Co-Producer |
| Pierre Tremblay | First Assistant Director |
| Guy Bews | Stunt Driver |
| Tori James | Assistant Art Director |
| Ricardo Olinger | Art Department Trainee |
| Peter Wunstorf | Second Unit Director of Photography |
| Drew Kunin | Production Sound Mixer |
| Tim Milligan | Dolly Grip |
| Ken Wills | Property Master |
| Justin Onofriechuk | Assistant Property Master |
| Maurice Routly | Special Effects Coordinator |
| Mark W. Jones | Driver |
| Pat Goettler | Graphic Designer |
| Damon Moreau | "A" Camera Operator |
| Peter Wunstorf | "B" Camera Operator |
| Trevor Holbrook | First Assistant "A" Camera |
| Christine Thomson | Costume Supervisor |
| Renee Bravener | Assistant Costume Designer |
| Mary-Lou Green-Benvenuti | Hair Department Head |
| David Vernerey | Best Boy Electric |
| Kim Olsen | Key Grip |
| John Adshead | Key Grip |
| Ivan Hawkes | Key Rigging Grip |
| Hudson Cooley | Production Coordinator |
| Brad Moerke | Second Assistant Director |
| Joy Ellison | Dialect Coach |
| Elizabeth Greenberg | Casting Associate |
| Alyson Lockwood | Extras Casting |
| Gerry Robert Byrne | Post Production Supervisor |
| Kimberly Saree Tomas | First Assistant Editor |
| Shelby Siegel | First Assistant Editor |
| Eugene Gearty | Supervising Sound Editor |
| Kenton Jakub | ADR Editor |
| Igor Nikolic | First Assistant Sound Editor |
| Chris Fielder | First Assistant Sound Editor |
| Frank Kern | Foley Supervisor |
| Kam Chan | Foley Editor |
| George A. Lara | Foley Recordist |
| Marko Costanzo | Foley Artist |
| Thomas J. O'Connell | ADR Mixer |
| Michael J. Fox | ADR Mixer |
| Barbara Harris | ADR Voice Casting |
| Rick Canelli | ADR Recordist |
| Michael J. Fox | ADR Recordist |
| Andy Wright | ADR Recordist |
| Jay Gallagher | ADR Recordist |
| Eugene Gearty | Sound Re-Recording Mixer |
| Reilly Steele | Sound Re-Recording Mixer |
| Jill Antal | Payroll Accountant |
| Danny C. Klepper | Transportation Coordinator |
| Tom Lloyd | Transportation Captain |
| Chantal Teasdale | Craft Service |
| Louis Morin | Visual Effects Supervisor |
| Tom Mayclim | Negative Cutter |
| Chris Hinton | Color Timer |
| Bradford L. Hohle | Dolby Consultant |
| Darryl Solly | Location Manager |
