 | Melissa McCarthy als Lee Israel |
 | Richard E. Grant als Jack Hock |
 | Dolly Wells als Anna |
 | Ben Falcone als Alan Schmidt |
 | Gregory Korostishevsky als Andrei |
 | Jane Curtin als Marjorie |
 | Stephen Spinella als Paul |
 | Christian Navarro als Kurt |
 | Pun Bandhu als Agent Doyle |
 | Erik LaRay Harvey als Agent Solanas |
 | Brandon Scott Jones als Glen |
 | Shae D'Lyn als Nell |
 | Rosal Colon als Rachel |
 | Anna Deavere Smith als Elaine |
 | Marc Evan Jackson als Lloyd |
 | Marcella Lowery als Guest at Party |
 | Roberta Wallach als Tom Clancy Groupie |
 | Tina Benko als Karen |
 | Sandy Rosenberg als Yale Librarian |
 | Kevin Carolan als Tom Clancy |
 | Ben Rauch als Coat Check Guy |
 | Ethel Fisher als Mrs. Unger |
 | Chris Lamberth als Exterminator |
 | Joanna Adler als Arlene |
 | Mary B. McCann als Judge |
| Michael Laurence als Fenwick |
 | Michael Cyril Creighton als Harry |
 | Alice Kremelberg als Server |
 | Moisés Acevedo als Stationery Clerk |
 | Lucy DeVito als Gossipy Office Worker |
 | Josh Evans als Boss in Office |
 | Ricky Garcia als Security Guard |
 | Charlotte Mary Wen als Cubicle Worker |
 | Marcus Choi als Another Cubicle Worker |
 | Justin Vivian Bond als Lounge Singer |
 | Tim Cummings als Craig |
| Havilah Brewster als Toni |
 | Dann Fink als Male (voice) |
 | Zabryna Guevara als Female (voice) |
| Bonita Hamilton als Female (voice) |
| Dan McCabe als Male (voice) |
| Sean Oliver als Male (voice) |
| Lori Prince als Female (voice) |
 | Armando Riesco als Male (voice) |
| Sandy Rustin als Female (voice) |
 | George Aloi als Literary Agent (uncredited) |
| Tiffany Blair als Lady with Bird (uncredited) |
 | Linwood Brown als Prosecutor (uncredited) |
| Kevin Cristaldi als Other Dealer (uncredited) |
| Barbara Ann Davison als Bookstore Employee (uncredited) |
| Peter Donovan als Greg (uncredited) |
| Antoine Drye als Musician in Bar Scene (uncredited) |
| Liz Eng als Lisa (uncredited) |
| George R. Golden als Bookshop Browser (uncredited) |
| Anne Hollister als Young Girl at Vet (uncredited) |
| Katie Kocik als Bookstore Customer (uncredited) |
| Ron Maestri als Book Store Customer (uncredited) |
 | Doris McCarthy als Dinner Guest (uncredited) |
 | Wayne J. Miller als Pancake Man at Counter (uncredited) |
 | Bill Walters als Homeless Man (uncredited) |
| Lee Israel | Book |
| Marielle Heller | Director |
| Nicole Holofcener | Screenplay |
| Stephen H. Carter | Production Design |
| Ma Kalaadevi Ananda | Makeup Department Head |
| Shannen Walsh | Visual Effects Coordinator |
| Marci Mudd | Art Direction |
| Matthew T. Griffin | Visual Effects Producer |
| Deborah Wheatley | Assistant Art Director |
| Bob Balaban | Executive Producer |
| Joe White | Sound Mixer |
| Damian Volpe | Supervising Sound Editor |
| Jawal Nga | Executive Producer |
| Pamela Hirsch | Executive Producer |
| Robert Fernandez | Sound Re-Recording Mixer |
| Anne McCabe | Editor |
| Amy Nauiokas | Producer |
| Jeff Whitty | Screenplay |
| Arjun Bhasin | Costume Design |
| Brandon Trost | Director of Photography |
| Nate Heller | Original Music Composer |
| David Yarnell | Producer |
| Glenfield Payne | Sound Effects Editor |
| Anne Carey | Producer |
| Sarah E. McMillan | Set Decoration |
| Todd Antonio Somodevilla | "B" Camera Operator |
| Pamela Hirsch | Unit Production Manager |
| T.K. Knowles | Associate Producer |
| Matt Duncan | Set Decoration Buyer |
| John S. Moyer | Steadicam Operator |
| Howard Paar | Music Supervisor |
| Henriette Lopez | Assistant Set Decoration |
| Jennifer Euston | Casting |
| Tim Metivier | First Assistant "A" Camera |
| Andrea Burrell | Graphic Designer |
| Truman Clark McCasland | Art Department Coordinator |
| Graham Burt | First Assistant "B" Camera |
| Timothy R. Boyce Jr. | Boom Operator |
| Chuck Ryant | Associate Producer |
| Matthew Selkirk | Digital Imaging Technician |
| Rebecca Breckel | Script Supervisor |
| Chelsea Ryan | Second Assistant Director |
| Jack Mortellaro Jr. | Leadman |
| Graham Burt | Second Assistant "A" Camera |
| Brian Lynch | Loader |
| John O'Grady | Associate Producer |
| Graham Wichman | Set Decoration Buyer |
| Brian Lynch | Second Assistant "B" Camera |
| Shani Geva | Associate Producer |
| John S. Moyer | "A" Camera Operator |
| Jill Alexander | Property Master |
| Charlie Dibe | Unit Production Manager |
| Karen Kane | First Assistant Director |
| Mary Cybulski | Still Photographer |
| Kelley Cribben | Post Production Supervisor |
| Rachel Chancey | Foley Editor |
| Bruce Winant | ADR Voice Casting |
| Lawrence Bell | Tailor |
| Mike Myers | Special Effects Coordinator |
| Vance Miller | CG Supervisor |
| Alyssa Alimaras | Location Assistant |
| Hannah L. Smith | Production Secretary |
| Nate Heller | Orchestrator |
| James Hammer | Assistant Costume Designer |
| Barbara Sansone | Hairstylist |
| Nick Pray | Assistant Location Manager |
| David M. Waldron | Background Casting Director |
| Josh Nadelman | Assistant Production Coordinator |
| Shellie Gillespie | Production Accountant |
| Frank Beggins | Transportation Co-Captain |
| David Stern | Key Grip |
| Erika Abberton | Hairstylist |
| Michael Herlihy | Construction Coordinator |
| Lisa Green | Assistant Property Master |
| Robert Hein | Sound Effects Editor |
| Tracey Phillips-Boone | Costume Supervisor |
| Linda D. Flowers | Wig Designer |
| Loriel Letizia | Location Coordinator |
| Tony Behringer | Background Casting Director |
| John Bair | Visual Effects Supervisor |
| Mike Morini | Dolly Grip |
| Cinder Chou | Production Coordinator |
| Tony Martinez | Dialogue Editor |
| Filipe Messeder | Assistant Sound Editor |
| Jessica Hunt | Key Costumer |
| Jen Grubbs | Costume Assistant |
| Patrick O'Hala | Assistant Location Manager |
| Renuka Ballal | Visual Effects Producer |
| Bobby Johanson | ADR Mixer |
| Victoria Wood | Wigmaker |
| Sean Heilig | Transportation Captain |
| Dave Palestine | Dolly Grip |
| Kayla Viani | Costumer |
| Dann Fink | ADR Voice Casting |
| Jimmy Gribbin | Location Assistant |
| Stephanie DeCourcey | Background Casting Director |
| Michael Rivera | ADR Recordist |
| Jay Peck | Foley Artist |
| Christa Lewandowski | Costume Coordinator |
| Lemuel Herarte | Costume Assistant |
| Brooke Ensign | Unit Publicist |
| Kim Safatsky | Animal Wrangler |
| Jamie Coffey | Payroll Accountant |
| Richard P. Ulivella | Chief Lighting Technician |
| Matt Snedecor | Foley Recordist |
| Sascha Springer | Location Manager |
| Adam Dicterow | First Assistant Editor |
| Adam Bennati | Music Coordinator |
| Ted Caplan | Music Editor |
| Ma Kalaadevi Ananda | Makeup Artist |
| Dahlia Warner | Key Makeup Artist |
| S.J. Allocco | Casting Associate |
