 | Owen Wilson als Lightning McQueen (voice) |
 | Cristela Alonzo als Cruz Ramirez (voice) |
 | Chris Cooper als Smokey Yunick (voice) |
 | Nathan Fillion als Sterling (voice) |
 | Armie Hammer als Jackson Storm (voice) |
 | Larry the Cable Guy als Mater (voice) |
 | Bonnie Hunt als Sally Carrera (voice) |
 | Lea DeLaria als Miss Fritter (voice) |
 | Kerry Washington als Natalie Certain (voice) |
 | Tony Shalhoub als Luigi (voice) |
 | Guido Quaroni als Guido (voice) |
 | Lloyd Sherr als Fillmore (voice) |
 | Paul Dooley als Sarge (voice) |
 | Cheech Marin als Ramone (voice) |
 | Jenifer Lewis als Flo (voice) |
 | Lewis Hamilton als Hamilton (voice) |
 | Bob Costas als Bob Cutlass (voice) |
 | Bob Peterson als Chick Hicks (voice) |
 | Katherine Helmond als Lizzie (voice) |
 | John Ratzenberger als Mack (voice) |
 | Michael Wallis als Sheriff (voice) |
 | Ray Magliozzi als Dusty (voice) |
 | Tom Magliozzi als Rusty (voice) |
 | Junior Johnson als Junior 'Midnight' Moon (voice) |
 | Margo Martindale als Louise 'Barnstormer' Nash (voice) |
 | Chase Elliott als Chase Racelott (voice) |
 | Ryan Blaney als Ryan 'Inside' Laney (voice) |
 | Darrell Waltrip als Darrell Cartrip (voice) |
| Shannon Spake als Shannon Spokes (voice) |
| Humpy Wheeler als Tex (voice) |
 | Jeff Gordon als Jeff Gorvette (voice) |
 | Daniel Suárez als Danny Swervez (voice) |
 | Kyle Petty als Cal Weathers (voice) |
 | Mike Joy als Mike Joyride (voice) |
| Ray Evernham als Ray Reverham (voice) |
 | Richard Petty als Strip "The King" Weathers (voice) |
 | Jason Pace als Radio Sports Talk DJ (Voice) |
 | Angel Oquendo als Bobby Swift (voice) |
 | Madeleine McGraw als Maddy McGear (voice) |
 | Andra Day als Sweet Tea (voice) |
 | Bubba Wallace als Bubba Wheelhouse (voice) |
 | Isiah Whitlock Jr. als River Scott (voice) |
 | Paul Newman als Doc Hudson (voice) (archive recording) |
| Brian Fee | Director |
| Kevin Reher | Producer |
| Brian Fee | Original Story |
| Mike Rich | Screenplay |
| Ben Queen | Original Story |
| Aaron Conover | Visual Effects |
| Bob Peterson | Screenplay |
| Randy Newman | Original Music Composer |
| Jonathon E. Stewart | Original Story |
| Blake Collins | Foley |
| Eyal Podell | Original Story |
| Kiel Murray | Screenplay |
| Kevin Reher | Casting |
| Natalie Lyon | Casting |
| Angelo Libutti | Storyboard |
| John Lasseter | Executive Producer |
| Jeremy Lasky | Director of Photography |
| Craig Foster | Art Direction |
| Christine Crowley | Production Assistant |
| Scott Hosfeld | Musician |
| Tom Myers | Sound Re-Recording Mixer |
| Brian Chumney | Supervising Sound Editor |
| Andrew Wheeler | VFX Artist |
| Paul Oakley | Master Lighting Artist |
| Michael Rutter | Set Dressing Artist |
| Bobby Podesta | Supervising Animator |
| Louis Gonzales | Storyboard Artist |
| Darla K. Anderson | Thanks |
| Denise Ream | Thanks |
| Jose Ignacio | Systems Administrators & Support |
| Diane Howard | Publicist |
| Mark Dinicola | Colorist |
| George Doering | Musician |
| Michael Fong | VFX Artist |
| Yung Lian Frank Tai | VFX Artist |
| Dorien Gunnels | Lighting Artist |
| Jon Bryant | Lighting Coordinator |
| Bernard Lizon | Layout |
| Montaque Ruffin | Animation |
| Scott Morse | Additional Writing |
| Paul Abadilla | Set Designer |
| Winston O. Good | Software Engineer |
| Steve Schaeffer | Musician |
| Rachael Bigelow | Assistant Sound Editor |
| Michael Semanick | Sound Re-Recording Mixer |
| E.J. Holowicki | Sound Effects Editor |
| Charlie Ramos | Layout |
| Tim Pixton | Animation |
| Jeff Gordon | Thanks |
| Humpy Wheeler | Thanks |
| Dan Berman | Systems Administrators & Support |
| Maura Turner | Production Coordinator |
| Bart Samolis | Musician |
| Erik Shepherd | VFX Artist |
| David Shavers | Master Lighting Artist |
| Jesse Weglein | Lighting Artist |
| Jonas Jarvers | Modeling |
| Dana Frankoff | Production Coordinator |
| Randy Newman | Conductor |
| Dana Murray | Post Production Supervisor |
| John Hoffman | Storyboard Artist |
| Xavier Riffault | Storyboard Artist |
| Chris Montan | Thanks |
| Galyn Susman | Thanks |
| Laura Finell | Production Coordinator |
| Jessica Heidt | Script Supervisor |
| Eric M. Barker | Assistant Editor |
| Susan Brunig | Color Grading |
| Karl Vincent | Musician |
| Benjamin A. Burtt | Sound Effects Editor |
| Ryan Heuett | Layout |
| Jude Brownbill | Animation Director |
| Royce Wesley | Animation Director |
| David Torres | Animation |
| Lance Fite | Animation |
| Jason Hudak | Editor |
| Noah Klocek | Art Direction |
| Emily Goldsborough | Production Coordinator |
| Gregory Amundson | Additional Editor |
| Qianbaihui Yang | Foley Editor |
| Aaron Conover | VFX Artist |
| Dave Mullins | Animation |
| Michael Sauls | Animation |
| Neil Helm | Animation |
| Shawn Krause | Animation |
| William Cone | Production Design |
| Sophie Vincelette | Set Dresser |
| Rob Gibbs | Thanks |
| Brian Rankin | Security |
| Anthony David Duran | Post Production Coordinator |
| Dominick Certo | Music Editor |
| Don Williams | Musician |
| Blake Collins | Foley Mixer |
| Lloyd Bernberg | Master Lighting Artist |
| Matt DeMartini | Animation Manager |
| Ben Rush | Animation |
| Mike Stern | Animation |
| Ricky Wight | Animation |
| Michael Yates | Storyboard Artist |
| John Bickford | Thanks |
| Kori Rae | Thanks |
| Nic Bishop | Systems Administrators & Support |
| Chris Wiggum | Publicist |
| Jeff Gordon | Story Consultant |
| Daniel LaPook | Story Coordinator |
| Félix O. Santiago | Software Engineer |
| Jonathan Sacks | Orchestrator |
| Howard London | ADR Mixer |
| James Bartolozzi | Visual Effects Technical Director |
| Jay-Vincent Jones | Stereoscopic Technical Director |
| Burt Peng | Lighting Artist |
| Nick Berry | Art Department Manager |
| Andrew Atteberry | Animation |
| Kim White | Director of Photography |
| Michael Sparber | Director of Photography |
| Nicole Paradis Grindle | Thanks |
| Tom MacDougall | Executive Music Producer |
| Dennie Thorpe | Foley Artist |
| Geoff Vaughan | Foley Artist |
| Stewart Pomeroy | Stereoscopic Technical Director |
| Charu Clark | Master Lighting Artist |
| Eric Lacroix | Visual Effects Technical Director |
| Andrea Goh | Layout |
| Jay Shuster | Production Design |
| Michael Daley | Storyboard Artist |
| Doug Berman | Thanks |
| Gates Roberg-Clark | Software Engineer |
| Joe Garrity | Assistant Editor |
| Amera Rizk | First Assistant Editor |
| Helen Z. Altenbach | Musician |
| Eric Lacroix | VFX Artist |
| Mark C. Harris | Animation Director |
| Stacey Truman | Shading |
| Benjamin Su | Animation |
| Kevin O'Brien | Storyboard Artist |
| Andrea Warren | Co-Producer |
| Laura Phillips | Art Direction |
| Corbin Hayes | Additional Music |
| Andrew Synowiec | Musician |
| Eric Bradley | Musician |
| David Boucher | Scoring Mixer |
| Tom Myers | Supervising Sound Editor |
| Farhez Rayani | Lighting Artist |
| Adam Rodriguez | Animation |
| Scott Morse | Story Supervisor |
| Pamela Darrow | Production Manager |
| Jessie Thiele | Post Production Supervisor |
| Jessica Katz | Script Coordinator |
| Don Davis | Orchestrator |
| Jan Pfenninger | Layout |
| Rejean Bourdages | Storyboard Artist |
| Rick Hendrick | Thanks |
| Jon Vargo | Assistant Editor |
| Jonathan Vargo | Assistant Editor |
| Mike H. Mahony | Software Engineer |
| Serena McKinney | Musician |
| Michael Silvers | ADR Editor |
| Tom Myers | Sound Designer |
| Ryan Kautzman | Software Engineer |
| Ernesto Nemesio | Matte Painter |
| Catherine Hang-Hicks | Animation |
| Erin Crocker | Thanks |
| Ray Evernham | Thanks |
| Joe E. Rand | Music Editor |
| Fred Kron | Musician |
| Jana Vance | Foley Artist |
| Erin Lehmkühl | Stereoscopic Technical Director |
| Brian Boyd | Master Lighting Artist |
| Adam Habib | Layout |
| Simon Christen | Animation |
| Tal Shwarzman | Animation |
| Nathan Wall | Animation |
| Edgar Karapetyan | Storyboard Artist |
| John Walker | Thanks |
| Shaun Brown | Systems Administrators & Support |
| Briana Gardner | Publicist |
| Kate Lardiere | Finance |
| Matt Chamberlain | Musician |
| Vincent Cosson | ADR Mixer |
| Anthony De Francesco | First Assistant Sound Editor |
| Nathan Nance | Sound Re-Recording Mixer |
| Jamie Williams | Visual Effects Technical Director |
| Steve Avoujageli | Visual Effects Technical Director |
| Evan Denmark | VFX Artist |
| Marlena Fecho | VFX Artist |
| Jose Luis Ramos | Master Lighting Artist |
| Linhan Li | Lighting Artist |
| Amit Baadkar | Visual Effects Technical Director |
| Brendan Beesley | Animation |
| Claudio de Oliveira | Animation |
| James W. Brown | Animation |
| Shad Bradbury | Animation |
| Josh Holtsclaw | Graphic Designer |
| Jerome Ranft | Sculptor |
| Kevin Connolly | Musician |
| Wade Culbreath | Musician |
| Teresa Eckton | Foley Editor |
| Jon Reisch | Visual Effects Supervisor |
| Jahkeeli Garnett | Layout |
| Jean-Claude Tran | Animation |
| Jessica Torres | Animation |
| Sam Hood | Story Artist |
| Barbara Harris | ADR Voice Casting |
| Christian Roman | Story Artist |
| Kenny Pickett | Sound Editor |
