 | Will Smith als Dr. Bennet Omalu |
 | Alec Baldwin als Dr. Julian Bailes |
 | Albert Brooks als Dr. Cyril Wecht |
 | Gugu Mbatha-Raw als Prema Mutiso |
 | David Morse als Mike Webster |
 | Arliss Howard als Dr. Joseph Maroon |
 | Mike O'Malley als Daniel Sullivan |
 | Eddie Marsan als Dr. Steven DeKosky |
 | Hill Harper als Christopher Jones |
 | Adewale Akinnuoye-Agbaje als Dave Duerson |
 | Stephen Moyer als Dr. Ron Hamilton |
 | Richard T. Jones als Andre Waters |
 | Paul Reiser als Dr. Elliot Pellman |
 | Luke Wilson als Roger Goodell |
 | Matthew Willig als Justin Strzelczyk |
 | Elizabeth Tulloch als Keana Strzelczyk |
 | Jason Davis als Defense Attorney |
 | Sara Lindsey als Gracie |
 | Kevin Jiggetts als FBI Agent |
 | Gary Grubbs als FBI Agent |
 | L. Scott Caldwell als Waters' Mother |
 | Joni Bovill als Mrs. Scott |
 | Joshua Elijah Reese als Graveyard Tech |
 | Holt McCallany als Angry Neurologist |
 | David Flick als Hospital Security Guard |
| Kelley Davis als Assistant |
 | Samara Lee als Strzelczyk's Daughter |
 | Nathan Hollabaugh als Young Reporter |
 | Britanni Johnson als Rachel Green |
 | Randy Kovitz als Deputy Mayor |
 | Dan Ziskie als Paul Tagliabue |
 | Larry John Meyers als Father D'Amico |
| Dan Anders als College Coach |
| Jeb Keller als High School Coach |
| Jackie Schafer als TV Reporter (Webster Site) |
| Mike Clark als TV Reporter (Interview) |
 | Jared Pfennigwerth als Tech |
 | Phillip Chorba als Tech |
| Alison Moir als Colleen Bailes |
| Dino Rende als Strzelczyk's Son |
 | Cindy Jackson als Paramedic |
| Scott Miller als Contractor |
| Michael Schaich als Security Guard |
| Hennessey Joseph als NFL Employee |
| Antonia Long als Piano Player |
| Lisa Earley als Lodi Morgue Tech |
| Ann B. Betters als Cantor |
 | Joe Fishel als Louisville Head Football Coach |
| Dihlon McManne als Reporter at Westin |
 | Brittney Aleah als Altar Server (uncredited) |
 | Christopher Boyer als Crockett (uncredited) |
| Deborah Charity als Attorney (uncredited) |
| Amy Lyn Elliott als Business Woman (uncredited) |
| Joe Gallipoli als Doctor (uncredited) |
 | Carmen Gangale als Doctor (uncredited) |
| Trevor Lee Georgeson als NFL Mourner (uncredited) |
| David Gragg als Football Coach (uncredited) |
 | Eme Ikwuakor als Amobi Okoye (uncredited) |
| Dontez James als Corpse (uncredited) |
| Wendell Kinney als NFL Football Player (uncredited) |
| David Dale McCue als Pittsburgh Police Officer (uncredited) |
| Ben McDonnell als Young Webster (uncredited) |
 | Robert G. McKay als Mr. Scott (uncredited) |
 | F. Robert McMurray als NFL Lawyer (uncredited) |
| Kimberly Ryans als Business Woman (uncredited) |
| P. Scott Conner als ER Doctor |
 | Jared Scott als Justin Strelczyk (uncredited) |
| Jackson Nunn als Church Member (uncredited) |
| Peter Landesman | Director |
| Peter Landesman | Writer |
| Ridley Scott | Producer |
| Jeanne Marie Laskas | Writer |
| Lindsay Graham Ahanonu | Casting |
| William Goldenberg | Editor |
| Tom Frohling | Art Direction |
| Larry Shuman | Producer |
| Salvatore Totino | Director of Photography |
| David Crank | Production Design |
| Michael Schaefer | Executive Producer |
| David Wolthoff | Producer |
| Giannina Facio-Scott | Producer |
| David Crockett | Executive Producer |
| James Newton Howard | Original Music Composer |
| Elizabeth Cantillon | Producer |
| Mary Vernieu | Casting |
| Amal Baggar | Co-Producer |
| Dayna Pink | Costume Design |
| Michael Dolhi | Greensman |
| Buster Pile | Construction Coordinator |
| Christian P. Minkler | Sound Re-Recording Mixer |
| Kathrine Gordon | Hair Department Head |
| Steve Cohagan | Rigging Gaffer |
| Ray Bivins | Special Effects Coordinator |
| Michael Minkler | Sound Re-Recording Mixer |
| Tracy Scott | Script Supervisor |
| Peter Geraghty | First Assistant Camera |
| Chris Gallaher | Makeup Effects |
| Tami Lane | Makeup Effects |
| Marisol Roncali | Casting Associate |
| Gary A. Hecker | Foley |
| Linda Weaver | Casting Associate |
| Megan Graham | Script Supervisor |
| Sherri Bramlett | Key Hair Stylist |
| David Alonzo | Digital Intermediate |
| Kari Kramer | Seamstress |
| Melinda Sue Gordon | Still Photographer |
| James V. Kent | Set Decoration |
| Yen Do | Set Costumer |
| Antonio Andraus | Leadman |
| Andrew S. Eisen | First Assistant Editor |
| Justin Pelissero | Leadman |
| John S. Moyer | Camera Operator |
| Jamie Dixon | Visual Effects Supervisor |
| Judy Murdock | Makeup Artist |
| Morning Star Schott | Digital Intermediate |
| Michele C. Vallillo | Visual Effects Producer |
| Jacenda Burkett | Makeup Department Head |
| Jenn Albaugh | Art Department Coordinator |
| Stacy Caballero | Assistant Costume Designer |
| Rick Owens | Foley |
| Ando Johnson | Sound Effects Editor |
| David Esparza | Sound Designer |
| Christina Myal | Assistant Art Director |
| Dave McMoyler | Supervising Sound Editor |
| Dylan Goss | Helicopter Camera |
| Pierce Austin | Hairstylist |
| Brian Greenway | First Assistant Camera |
| Marianne Skiba | Makeup Artist |
| Michelle Eisenreich | Visual Effects Producer |
| Dana Kay Hart | Costume Supervisor |
| Jay Kemp | Gaffer |
| Ben Waisbren | Executive Producer |
| Greg Basser | Executive Producer |
| Bruce Berman | Executive Producer |
| Michael Ford | Visual Effects Supervisor |
| Robert Troy | Dialogue Editor |
| Michelle Pazer | Dialogue Editor |
| Matthew Cavaliero | Property Master |
| Doug Delaney | Colorist |
