 | Frank Welker als Curious George (voice) |
 | Angela Bassett als Dr. Kulinda (voice) |
 | John Goodman als Houston (voice) |
 | Jeff Bennett als Ted (voice) |
 | Alexander Polinsky als Tech Andrew (voice) |
| Chuck Tately | Writer |
| Ron Howard | Executive Producer |
| Phil Weinstein | Director |
| Brian Grazer | Executive Producer |
| David Kirschner | Executive Producer |
| Jon Shapiro | Executive Producer |
| Share Stallings | Producer |
| José Zelaya | Character Designer |
| José Zelaya | Prop Designer |
| Andoni Achaval | Line Producer |
| John Dale Cunanan | Production Coordinator |
| Doris Quemado | Production Manager |
