 | Benedict Cumberbatch als Grinch (voice) |
 | Rashida Jones als Donna Lou Who (voice) |
 | Kenan Thompson als Bricklebaum (voice) |
 | Cameron Seely als Cindy Lou Who (voice) |
 | Angela Lansbury als Mayor McGerkle (voice) |
 | Pharrell Williams als Narrator (voice) |
 | Brad O'Hare als Groopert (voice) |
 | Ramone Hamilton als Axl (voice) |
 | Sam Lavagnino als Ozzy (voice) |
 | Scarlett Estevez als Izzy (voice) |
| Tristan O'Hare als Groopert (voice) |
 | Michael Beattie als Store Clerk (voice) |
 | Scott Mosier als Additional Voices (voice) |
 | Lori Alan als Additional Voices (voice) |
 | Carter Hastings als Additional Voices (voice) |
 | Carlos Alazraqui als Additional Voices (voice) |
 | John Kassir als Additional Voices (voice) |
 | Doug Burch als Additional Voices (voice) |
| Evan Kishiyama als Additional Voices (voice) |
 | Cathy Cavadini als Additional Voices (voice) |
 | Danny Mann als Additional Voices (voice) |
| Tucker Chandler als Additional Voices (voice) |
| Michael LeSieur | Screenplay |
| Yarrow Cheney | Director |
| Dr. Seuss | Story |
| Chris Cartagena | Editor |
| Danny Elfman | Music |
| Audrey Geisel | Executive Producer |
| Janet Healy | Producer |
| Brett Hoffman | Associate Producer |
| Christopher Meledandri | Producer |
| Scott Mosier | Producer |
| Chris Renaud | Executive Producer |
| Colin Stimpson | Art Direction |
| Dave Rosenbaum | Production Manager |
| Robert Taylor | Associate Producer |
| Scott Mosier | Director |
| Jeannine Berger | Post Production Supervisor |
| Cinzia Angelini | Storyboard Artist |
| Delphine Le Roch | Production Supervisor |
| Eileen Godoy | Post Production Supervisor |
| Gaëlle Santamarta | Assistant Production Manager |
| Charles Seignolle | VFX Supervisor |
| David Acord | Sound Designer |
| Blake Collins | Foley Mixer |
| Christopher Flick | Foley Supervisor |
| Pascal Garneau | Sound Effects Editor |
| Jonathan Greber | Dialogue Editor |
| Jim Likowski | Foley Editor |
| Dennis Leonard | Supervising Sound Editor |
| John Roesch | Foley Artist |
| Geoff Vaughan | Foley Artist |
| Bonnie Wild | Sound Effects Editor |
| Miguel Jiron | Storyboard Artist |
| Tommy Swerdlow | Screenplay |
