 | Matt Dillon als Bob |
 | Kelly Lynch als Dianne |
 | James Remar als Gentry |
 | James Le Gros als Rick |
 | Heather Graham als Nadine |
 | Beah Richards als Drug Counselor |
 | Grace Zabriskie als Bob's Mother |
 | Max Perlich als David |
 | William S. Burroughs als Tom the Priest |
 | Eric Hull als Druggist |
 | John Kelly als Cop |
 | George Catalano als Trousinski |
| Janet Baumhover als Neighbor Lady |
 | Ted D'Arms als Neighbor Man |
| Neal Thomas als Halamer |
| Stephen Rutledge als Hotel Manager |
| Robert Lee Pitchlynn als Hotel Clerk |
| Roger Hancock als Machinist |
| Michael Parker als Crying Boy |
| Ray Monge als Accomplice |
 | Gus Van Sant als Himself (uncredited) |
| Gus Van Sant | Screenplay |
| Daniel Yost | Screenplay |
| Richard Pagano | Casting |
| Margaret Goldsmith | Set Decoration |
| Robert D. Yeoman | Director of Photography |
| Sharon Bialy | Casting |
| Gus Van Sant | Director |
| Eve Cauley | Art Direction |
| David Brisbin | Production Design |
| Elliot Goldenthal | Original Music Composer |
| Karen Murphy | Producer |
| Nick Wechsler | Producer |
| Cary Brokaw | Executive Producer |
| Mary Bauer | Editor |
| Jane Goldsmith | Script Supervisor |
| Gina Monaci | Hair Designer |
| Lizbeth Williamson | Makeup Artist |
| Joel Iwataki | Sound Engineer |
| Curtiss Clayton | Editor |
| Laurie Parker | Production Executive |
| Claudia Lewis | Production Executive |
| Jerry Trent | Foley Artist |
| Robin Leigh Fleck | Second Assistant Director |
| Les Percy | Key Grip |
| Leslie A. Leitner | Post Production Supervisor |
| Joan Rowe | Foley Artist |
| Matthew Iadarola | Sound Re-Recording Mixer |
| Charles Harrington | Location Manager |
| James Fogle | Novel |
| Robert Jackson | Boom Operator |
| Dane A. Davis | Supervising Sound Editor |
| Wayne Heitman | Sound Re-Recording Mixer |
| Karen Koch | Production Manager |
| Missy Stewart | Set Dresser |
| Mark 'Frito' Long | Sound Recordist |
| Beatrix Aruna Pasztor | Costume Designer |
| John Kwiatkowski | Sound Effects Editor |
| Eric McLeod | Production Coordinator |
| David Boushey | Stunt Coordinator |
| David B. Householter | First Assistant Director |
| Michael Gastaldo | Property Master |
| Eric Alan Edwards | Second Unit Director of Photography |
| Ron Judkins | Sound Mixer |
| Marsha Perloff | Wardrobe Supervisor |
| Chris Morley | Gaffer |
