 | Johnny Depp als Ed Wood |
 | Martin Landau als Bela Lugosi |
 | Sarah Jessica Parker als Dolores Fuller |
 | Patricia Arquette als Kathy O'Hara |
 | Jeffrey Jones als Criswell |
 | Bill Murray als Bunny Breckinridge |
 | Lisa Marie als Vampira |
 | Jim Myers als Tor Johnson |
 | G. D. Spradlin als Reverend Lemon |
 | Vincent D'Onofrio als Orson Welles |
 | Mike Starr als Georgie Weiss |
 | Max Casella als Paul Marco |
 | Brent Hinkley als Conrad Brooks |
 | Juliet Landau als Loretta King |
 | Clive Rosengren als Ed Reynolds |
 | Norman Alden als Cameraman Bill (uncredited) |
 | Leonard Termo als Makeup Man Harry (uncredited) |
 | Ned Bellamy als Dr. Tom Mason (uncredited) |
 | Danny Dayton als Soundman (uncredited) |
 | Ross Manarchy als Camera Assistant (uncredited) |
 | Bill Cusack als Tony McCoy |
 | Stanley DeSantis als Mr. Feldman (uncredited) |
 | Biff Yeager als Rude Boss (uncredited) |
 | Joseph R. Gannascoli als Security Guard (uncredited) |
 | Carmen Filpi als Old Crusty Man (uncredited) |
 | Lisa Malkiewicz als Secretary #1 (uncredited) |
 | Melora Walters als Secretary #2 (uncredited) |
 | Conrad Brooks als Bartender (uncredited) |
 | Don Amendolia als Salesman (uncredited) |
 | Reid Cruickshanks als Stage Guard (uncredited) |
 | Lionel Decker als Executive #1 (uncredited) |
 | Edmund L. Shaff als Executive #2 (uncredited) |
 | Gene LeBell als Ring Announcer (uncredited) |
 | Bobby Slayton als TV Show Host (uncredited) |
 | Gretchen Becker als TV Host's Assistant (uncredited) |
 | John Rice als Conservative Man (uncredited) |
 | Catherine Butterfield als Conservative Wife (uncredited) |
 | Mary Portser als Backer's Wife (uncredited) |
 | King Cotton als Hick Backer (uncredited) |
 | Don Hood als Southern Backer (uncredited) |
 | Matthew Barry als Valet (uncredited) |
 | Ralph Monaco als Waiter (uncredited) |
 | Anthony Russell als Busboy (uncredited) |
 | Gregory Walcott als Potential Backer (uncredited) |
 | Charles C. Stevenson Jr. als Another Backer (uncredited) |
 | Rance Howard als Old Man McCoy (uncredited) |
 | Vasek Simek als Professor Strowski (uncredited) |
| Vinny Argiro als TV Horror Show Director (uncredited) |
 | Korla Pandit als Indian Musician (uncredited) |
 | Patti Tippo als Nurse (uncredited) |
 | Ray Baker als Doctor (uncredited) |
 | Louis Lombardi als Rental House Manager (uncredited) |
 | Jesse Hernandez als Wrestling Opponent (uncredited) |
 | Jim Boyce als Theatre Manager (uncredited) |
 | Ben Ryan Ganger als Angry Kid (uncredited) |
 | Charlie Holliday als Tourist (uncredited) |
 | Tommy Bertelsen als Tough Boy (uncredited) |
 | Adam Drescher als Photographer #1 (uncredited) |
| Ric Mancini als Photographer #2 (uncredited) |
 | Daniel Riordan als Pilot / Strapping Young Man (uncredited) |
 | Mickey Cottrell als Hammy Alien (uncredited) |
| Lena Banks als Sexy Pedestrian (uncredited) |
 | Maurice LaMarche als Orson Welles (voice) (uncredited) |
 | Ada Tai als Vampira's Friend (uncredited) |
 | Arlene Tai als Vampira's Friend (uncredited) |
 | Rayder Woods als Car Vandal (uncredited) |
 | Ralph Moratz als Extra (uncredited) |
 | Bill Blair als Carny (uncredited) |
 | Ryan Holihan als Frantic Usher |
| Cricket Rowland | Set Decoration |
| Tim Burton | Director |
| Howard Shore | Original Music Composer |
| Stefan Czapsky | Director of Photography |
| Tim Burton | Producer |
| Ve Neill | Makeup Artist |
| Denise Di Novi | Producer |
| Chris Lebenzon | Editor |
| Okowita | Art Direction |
| Tom Duffield | Production Design |
| Colleen Atwood | Costume Design |
| Scott Alexander | Screenplay |
| Larry Karaszewski | Screenplay |
| Victoria Thomas | Casting |
| Michael Lehmann | Executive Producer |
| Michael Flynn | Producer |
| Howard Jensen | Special Effects Coordinator |
| Kevin Pike | Special Effects |
| Paul Marco | Thanks |
| Michael Polaire | Unit Production Manager |
| Kathy Wood | Thanks |
| John Branagan | Stunt Coordinator |
| Janna Stern | Script Supervisor |
| Carrie Angland | Makeup Artist |
| Rick Baker | Makeup Designer |
| Ellen Segal | Music Editor |
| John Nutt | Supervising Sound Editor |
| Yolanda Toussieng | Key Hair Stylist |
| Paul Boyington | Visual Effects Supervisor |
| Bridget Cook | Hairstylist |
| Matt Rose | Makeup Artist |
| Philippe Carr-Forster | Camera Operator |
| Lucia Mace | Hairstylist |
| Tim Abbatoye | Transportation Co-Captain |
| Liz Matthews | Location Manager |
| David Gaines | Post Production Supervisor |
| Michelle Skoby | Assistant Costume Designer |
| Anthony G. Schmidt | Stunts |
| Hal Lary | Transportation Captain |
| Kent Burton | Animation |
| Philip Maldonado | Set Costumer |
| Kenn Smiley | Costume Supervisor |
| Nancy McArdle | Costume Supervisor |
| Brian Ruberg | ADR Mixer |
| Mildred Iatrou | Assistant Sound Editor |
| Lisa Chino | Assistant Sound Editor |
| Michael Semanick | Sound Re-Recording Mixer |
| Bill Dance | Extras Casting |
| Scott Levitin | Dialogue Editor |
| Mike Topoozian | First Assistant Director |
| Patrick Dodd | Dialogue Editor |
| David Franklin Bergad | Assistant Sound Editor |
| David Parker | Sound Re-Recording Mixer |
| Ernie Fosselius | Sound Effects Editor |
| Paul J. Zydel | ADR Mixer |
| Margie O'Malley | Foley Artist |
| Rich Schirmer | Sound Re-Recording Mixer |
| Joan E. Chapman | Dialogue Editor |
| Jennifer Myers | Foley Artist |
| Gregory Kent Simmons | Second Assistant Director |
| Samuel H. Hinckley | Sound Effects Editor |
| Edward Tise | Production Sound Mixer |
| Emily Ferry | Property Master |
| Jeff Courtie | ADR Mixer |
| Richard Duarte | Foley Recording Engineer |
| Richard Quinn | Assistant Sound Editor |
| Linda Lew | Foley Recording Engineer |
| Rudolph Grey | Book |
| Joni Avery | Stunts |
| James Leonard | Makeup Artist |
| Bobby Burns | Stunts |
