 | Anamaria Marinca als Rosa Dasque |
 | Michael Nyqvist als Andrei Blok |
 | Sharlto Copley als James Corrigan |
 | Daniel Wu als William Xu |
 | Karolina Wydra als Dr. Katya Petrovna |
 | Christian Camargo als Dr. Daniel Luxembourg |
 | Embeth Davidtz als Dr. Samantha Unger |
 | Dan Fogler als Dr. Sokolov |
 | Isiah Whitlock Jr. als Dr. Pamuk |
| Sebastián Cordero | Director |
| Philip Gelatt | Screenplay |
| Ben Browning | Producer |
| Michael Maher | Executive Producer |
| Jeremy Kipp Walker | Executive Producer |
| Bear McCreary | Original Music Composer |
| Enrique Chediak | Director of Photography |
| Alex Kopit | Editor |
| Craig McKay | Editor |
| Livio Sanchez | Editor |
| Aaron Yanes | Editor |
| Eugenio Caballero | Production Design |
| Anu Schwartz | Art Direction |
| Avy Kaufman | Casting |
| Leeba Zakharov | Casting |
| Anna Terrazas | Costume Design |
| Leo Won | Makeup Department Head |
| David Kalahiki | Makeup Artist |
| Joseph Whitmeyer | Hairstylist |
| Tessa Brophy | Art Department Coordinator |
| Sia Balabanova | Assistant Art Director |
| Casey Smith | Assistant Art Director |
| Peter Wright | Leadman |
| Benji Cox | Set Decoration |
| Douglas Poland | Set Decoration |
| Christopher Kay | Scenic Artist |
| Paul Bercovitch | Dialogue Editor |
| Shaun Brennan | Foley |
| Rich Bologna | Sound Designer |
| Jeff Seelye | Sound Editor |
| Tom Efinger | Sound Re-Recording Mixer |
| Drew Jiritano | Special Effects Coordinator |
| Dave Zeevalk | CGI Supervisor |
| Doug Appleton | Animation |
| John LePore | Animation |
| Andrew Paulus | Animation |
| Renuka Ballal | Visual Effects Producer |
| Raven Sia | Visual Effects Producer |
| John Bair | Visual Effects Supervisor |
| Jeff Wozniak | Visual Effects Supervisor |
| Brian Smyj | Stunt Coordinator |
| K.C. Bailey | Still Photographer |
| Joseph Quirk | Gaffer |
| Deirdra Elizabeth Govan | Costume Supervisor |
| Monika Darby | Set Costumer |
| Robin Fitzgerald | Set Costumer |
| Nat Jencks | Digital Intermediate |
| Dan Evans Farkas | Music Editor |
| Jess Platt | Dialect Coach |
| Atilla Salih Yücer | First Assistant Director |
| Joanna Lara Zuppardi | Production Coordinator |
| Naz Shams | Visual Effects Coordinator |
| Bindy St. Leger | Visual Effects Coordinator |
| Jamie Tracey | Visual Effects Coordinator |
| Bryan Wengroff | Visual Effects Coordinator |
| Jon Goracy | Casting Assistant |
| Aaron Vexler | Stunts |
| Chris Cenatiempo | Stunts |
| Gene Harrison | Stunts |
| Mick O'Rourke | Stunts |
| Michael Matera | Stunts |
| Victor Paguia | Stunt Double |
| Stephanie Stokes | Stunts |
