 | Robert De Niro als Frank Goode |
 | Drew Barrymore als Rosie |
 | Kate Beckinsale als Amy |
 | Sam Rockwell als Robert |
 | Melissa Leo als Colleen |
 | Damian Young als Jeff |
 | James Frain als Tom |
 | Katherine Moennig als Jilly |
 | Brendan Sexton III als Mugger |
 | James Murtaugh als Dr. Ed |
 | Austin Lysy als David |
 | Chandler Frantz als Young David |
 | Lily Mo Sheen als Young Amy |
 | Seamus Davey-Fitzpatrick als Young Robert |
 | Lucian Maisel als Jack |
| Jason Harris als Cab Rider #1 |
 | Ben Schwartz als Writer |
| Kirk Jones | Director |
| Kirk Jones | Screenplay |
| Ted Field | Producer |
| Andrew Jackness | Production Design |
| Meir Teper | Executive Producer |
| Glynis Murray | Producer |
| Gianni Nunnari | Producer |
| Chryss Hionis | Set Decoration |
| Dario Marianelli | Original Music Composer |
| Kerry Barden | Casting |
| Andrew Mondshein | Editor |
| Paul Schnee | Casting |
| Vittorio Cecchi Gori | Producer |
| Drew Boughton | Art Direction |
| Henry Braham | Director of Photography |
| Callum Greene | Executive Producer |
| Aude Bronson-Howard | Costume Design |
| Nathalie Peter-Contesse | Producer |
| Mike Weber | Executive Producer |
| Craig J. Flores | Executive Producer |
| Joe Rosenberg | Executive Producer |
| Ray Fisher | Leadman |
| Giuseppe Tornatore | Original Film Writer |
| Tonino Guerra | Original Film Writer |
| Massimo De Rita | Original Film Writer |
| David Gere | Stunts |
| Craig Clarke | Digital Compositor |
| Alexander H. Gayner | First Assistant Director |
