 | Jack Black als Po (voice) |
 | Awkwafina als Zhen (voice) |
 | Viola Davis als The Chameleon (voice) |
 | Dustin Hoffman als Shifu (voice) |
 | Bryan Cranston als Li (voice) |
 | James Hong als Mr. Ping (voice) |
 | Ian McShane als Tai Lung (voice) |
 | Ke Huy Quan als Han (voice) |
 | Ronny Chieng als Fish (voice) |
 | Lori Tan Chinn als Granny Boar (voice) |
 | Seth Rogen als Mantis (voice) |
 | Jimmy Donaldson als Panda Pig (voice) |
 | James Murray als Various (voice) |
 | James Sie als Bull Officer #2 / Ram Worker / Master Villain #1 (voice) |
 | Cedric Yarbrough als Bull Officer #1 / Ram Foreman / Questioned Boar (voice) |
 | Vic Chao als Bear Crime Boss / Last Ram / Tavern Patron #2 (voice) |
 | Audrey Brooke als Various (voice) |
 | Lincoln Nakamura als Various (voice) |
 | Cece Valentina als Den Bunny #1 / Restaurant Bunny #1 (voice) |
 | April Hong als Pig Patron #2 (voice) |
 | Suzanne Buirgy als Autograph-Seeking Fan #1 (voice) |
 | Logan Kim als Autograph-Seeking Fan #2 (voice) |
 | Reyn Doi als Adoring Fan (voice) |
 | Mick Wingert als Old Bunny Patron (voice) |
 | Peggy Etra als Pig Patron #1 / Questioned Croc (voice) |
 | Gedde Watanabe als Badger Crime Boss (voice) |
 | Karen Maruyama als Various (voice) |
 | Tom McGrath als Croc Crime Boss (voice) |
 | Phil LaMarr als Disheveled Bunny / Pig Thief / Questioned Bull (voice) |
 | Mike Mitchell als Tavern Patron #3 / Citizen #4 (voice) |
 | Colleen Smith als Various (voice) |
 | Sarah Sarang Oh als Questioned Antelope / Citizen #3 (voice) |
 | Paul Pape als Transforming Rhino (voice) |
 | James Taku Leung als Transforming Wolf (voice) |
 | Steve Alterman als Transforming Croc (voice) |
 | Christopher Knights als Annoyed Komodo (voice) |
 | Harry Shum Jr. als Fire-Breathing Croc (voice) |
| Natalia Cronembold | Associate Editor |
| Stephanie Ma Stine | Co-Director |
| Rebecca Huntley | Producer |
| Frank E. Abney III | Animation |
| Mike Mitchell | Director |
| Christopher Knights | Editor |
| Hans Zimmer | Original Music Composer |
| Justin Weg | Animation |
| Paul Duncan | Production Design |
| Steve Mazzaro | Original Music Composer |
| Christi Soper Hilt | Casting |
| Peter Maynez | Art Direction |
| Mary M. Quinn | Associate Producer |
| Betsy Nofsinger | Visual Effects Supervisor |
| Jonathan Aibel | Writer |
| Glenn Berger | Writer |
| Darren Lemke | Writer |
| Mike Mitchell | Executive Producer |
| Steven Schweickart | Co-Producer |
| Jonathan Aibel | Co-Producer |
| Glenn Berger | Co-Producer |
| Sean Sexton | Head of Animation |
| Calvin Tsang | Head of Story |
| Joshua Gunther | Head of Layout |
| Julien Bocabeille | Animation Supervisor |
| Ludovic Bouancheau | Animation Supervisor |
| Brooke Shay Bradford | Animation Supervisor |
| Laurent Caneiro | Animation Supervisor |
| Hans Dastrup | Animation Supervisor |
| Patrick Giusiano | Animation Supervisor |
| Antony Gray | Animation Supervisor |
| Mark Roennigke | Animation Supervisor |
| Max Bruce | Lighting Supervisor |
| Ariel Chisholm | Lighting Supervisor |
| Jonathan Ciscon | Lighting Supervisor |
| C. Jin Im | Lighting Supervisor |
| John J. Lee | Lighting Supervisor |
| Zachary Glynn | Effects Supervisor |
| Carl Hooper | Effects Supervisor |
| Alex Timchenko | Effects Supervisor |
| Andrew Wheeler | Effects Supervisor |
| Ethan van der Ryn | Supervising Sound Editor |
| Erik Aadahl | Supervising Sound Editor |
| Ethan van der Ryn | Sound Designer |
| Erik Aadahl | Sound Designer |
| Julian Slater | Sound Re-Recording Mixer |
| Greg P. Russell | Sound Re-Recording Mixer |
| Mark A. Hester | Associate Editor |
| Chelsea Blecha | Visual Development |
| Felicia Chen | Visual Development |
| Vahe Yefremian | Visual Development |
| Young-Ji Cha | Visual Development |
| Natalia Corsie | Visual Development |
| Hewrin Yoou | Visual Development |
| Wayne Tsay | Visual Development |
| Sabina Vafina | Production Assistant |
| Euni Cho | Lead Character Designer |
| Seth St. Pierre | Character Designer |
| Jorge García | Lead Animator |
| Tyler Phillips | Lead Animator |
| Kitty Fung | Animation |
| Steven Hornby | Animation |
| Prasanjib Nag | Animation |
| Ryan Page | Animation |
| Geoff Wheeler | Animation |
| Steven R.V. Johnson | Animation |
| Carlos F. Puertolas | Animation |
| Nideep Varghese | Animation |
| Janel Drewis | Animation |
| Philippe Le Brun | Animation |
| Daniel Edwards | Animation |
| Maarten Lemmens | Animation |
| Kelly Vawter | Animation |
| Chadd Ferron | Animation |
| David Lisbe | Animation |
| Ryan Vicik | Animation |
| Alex Flesig | Animation |
| Boris Maras | Animation |
| Richard A. Fournier | Animation |
| Brian Menz | Animation |
| Alvaro Michelena | Animation |
| Jeff Williams | Animation |
| Christopher Gonzalez | Animation |
| Bob Wilson | Animation |
| David Guo | Animation |
| Garrett O'Neal | Animation |
| John Wong | Animation |
| Bruno Hamzagic | Animation |
| Ivan Oviedo | Animation |
| Mikey Wong | Animation |
| John Han | Animation |
| Pete Paquette | Animation |
| Manar Al Tawam | Animation |
| Andrew Harkins | Animation |
| Yung Pham | Animation |
| Michael Berardini | Animation |
| Ryan Hobbiebrunken | Animation |
| David Polk | Animation |
| Guillermo Careaga | Animation |
| Anthony Hodgson | Animation |
| Reece Porter | Animation |
| Joseph Chong | Animation |
| Robyne Powell | Animation |
| David Couchariere | Animation |
| Guillaume Jallon | Animation |
| Nicolas Prothais | Animation |
| Michelle Cowart | Animation |
| Tom Davis | Animation |
| Aly Killian | Animation |
| Cory Rogers | Animation |
| Ares Deveaux | Animation |
| Kyle Kim | Animation |
| Matt Shepherd | Animation |
| Bill Diaz | Animation |
| Marek Kochout | Animation |
| Timothy Suarez | Animation |
| Paul Downs | Animation |
| André Lacroix | Animation |
| Liron Topaz | Animation |
| Ryan Rubin | Music Editor |
| Nacho Cantalejo | Orchestrator |
| Joan Martorell | Orchestrator |
| Gavin Greenaway | Conductor |
| Òscar Senén | Orchestrator |
| Simon Wells | Story Artist |
| Carder Scholin | Story Artist |
| Gary Graham | Story Artist |
| Johane Matte | Story Artist |
| Michelle Ku | Story Artist |
| Paulene Phouybanhdyt | Story Artist |
| Sam Szymanski | Story Artist |
| Travis Chen | Story Artist |
| Trey Buongiorno | Story Artist |
| Young Ki Yoon | Story Artist |
| Anna Beatrice Carlos | Production Coordinator |
| Katie Parody | First Assistant Editor |
| Keith Bodmer | Assistant Editor |
| Mark Gillins | Associate Editor |
| Brian Hopkins | Associate Editor |
| Lucy Feng | Character Designer |
| Borja Montoro | Character Designer |
| Sara Elenen | Production Coordinator |
| Avery Stevens | Production Coordinator |
| Charlotte Ruth Tobias | Additional Production Assistant |
| Geoff Foster | Score Engineer |
| Alan Meyerson | Scoring Mixer |
| John Prestage | Other |
| Chris Barrett | Other |
| Brynne Orloski | Post Production Supervisor |
| Dan Gamache | Sound Designer |
| David V. Butler | Dialogue Editor |
| David V. Butler | ADR Editor |
| Xiao'ou Olivia Zhang | Sound Effects Editor |
| Jon Greasley | Sound Effects Editor |
| Malte Bieler | Sound Effects Editor |
| Jesse Rosenman | Assistant Sound Editor |
| Veronica Li | Assistant Sound Editor |
| Jonathan Klein | Foley Editor |
| Dan O'Connell | Foley Artist |
| John T. Cucci | Foley Artist |
| Tavish Grade | Foley Mixer |
| Jack Cucci | Foley Mixer |
| Mikel Parraga-Wills | Foley Mixer |
| Ken Gombos | Other |
| Rick Hromadka | Sound Designer |
| Matt Brandseth | Mixing Engineer |
| Brianna Rivera | Other |
| Kristal Santos Pagan | Post Production Coordinator |
| Yvonne Ontiveros Slobin | Production Coordinator |
| Hadley Roslyn | Production Assistant |
| Erin Caswell | 3D Modeller |
| Catherin Cubillan Reyes | 3D Modeller |
| Chelle Mill | 3D Modeller |
| Kull Shin | 3D Modeller |
| James E. Stapp | 3D Modeller |
| Sarah Vawter | 3D Modeller |
| Christen Rangel | Production Assistant |
| Lara Boushehri | Casting Associate |
| Chloe Joy Schneider | Casting Assistant |
| Alexander Hunt | Production Accountant |
