 | Denzel Washington als Whip Whitaker |
 | Don Cheadle als Hugh Lang |
 | Kelly Reilly als Nicole |
 | John Goodman als Harling Mays |
 | Bruce Greenwood als Charlie Anderson |
 | Brian Geraghty als Ken Evans |
 | Tamara Tunie als Margaret Thomason |
 | Nadine Velazquez als Katerina Marquez |
 | Peter Gerety als Avington Carr |
 | Garcelle Beauvais als Deana |
 | Melissa Leo als Ellen Block |
 | Carter Cabassa als Son on Plane |
 | Adam C. Edwards als Father on Plane |
| Conor O'Neill als Kip |
 | Charlie E. Schmidt als Tiki Pot |
| Will Sherrod als Schecter |
 | Boni Yanagisawa als Camelia Satou |
 | Adam Tomei als Fran |
 | Dane Davenport als Derek Hogue |
 | John Crow als Field Reporter |
 | E. Roger Mitchell als Craig Matson |
 | Ravi Kapoor als Dr. Kenan |
 | Jill Jane Clements als Morning Nurse |
 | Tommy Kane als Mark Mellon |
 | James Badge Dale als Gaunt Young Man |
 | Susie Spear Purcell als Waitress |
 | Philip Pavel als Bartender |
 | Piers Morgan als Himself |
| Jim Tilmon als Himself |
| Charles Z. Gardner als Pentecostal Minister |
 | Tom Nowicki als Len Caldwell |
 | Jason Benjamin als Carr's Business Guy / Stalking Reporter |
 | Ric Reitz als Carr's Attorney |
| Timothy Adams als Whip's Dad |
| Darius Woods als Young Will |
| Ron Caldwell als Trevor |
 | Dylan Kussman als Two Beer Barry |
 | Janet Metzger als Sheila |
 | Bethany Anne Lind als Vicky Evans |
 | Sharon Blackwood als Peach Tree Employee |
 | Pam Smith als Peach Tree Employee |
 | Justin Martin als Will Whitaker Jr. |
| Shannon Walshe als Tilda Banden |
 | Rhoda Griffis als Amanda Anderson |
 | Michael Beasley als Officer Edmonds |
| Ted Hall als TV Reporter |
 | Laila Pruitt als Girl on Elevator |
| Precious Bright als Mom on Elevator |
 | Steve Coulter als NTSB Officer at Hearing |
 | Ted Huckabee als Prison Guard |
| Sarah Clark als Radio Talk Show Host (voice) |
| Vinnie Hasson als Radio Talk Show Host (voice) |
 | Randy Thom als Radio Stock Market Reporter (voice) |
| Dennis P. Wise als Air Traffic Controller (voice) |
| Paul Volle als Air Traffic Controller (voice) |
 | Hal Williams als Whip's Dad (voice) |
 | Kwesi Boakye als Young Will (voice) |
 | Jennifer Olympia Bentley als Naked Girl in Helmet (uncredited) |
| Goro Koyama | Foley |
| Randy Thom | Sound Designer |
| Sarah Carter | Set Decoration Buyer |
| Andy Malcolm | Foley |
| Dennis Leonard | Sound Designer |
| Robert Zemeckis | Director |
| Laurie MacDonald | Producer |
| Walter F. Parkes | Producer |
| Jack Rapke | Producer |
| Steve Starkey | Producer |
| Robert Zemeckis | Producer |
| Don Burgess | Director of Photography |
| Jeremiah O'Driscoll | Editor |
| David Lazan | Art Direction |
| Nelson Coates | Production Design |
| James Edward Ferrell Jr. | Set Decoration |
| Victoria Burrows | Casting |
| Alan Silvestri | Original Music Composer |
| Louise Frogley | Costume Design |
| Charles Croughwell | Stunt Coordinator |
| Robert Presley | Steadicam Operator |
| Alex L. Worman | Unit Publicist |
| Teressa Hill | Hairstylist |
| Katrina Chevalier | Hairstylist |
| Larry M. Cherry | Hairstylist |
| Tracey Moss | Hairstylist |
| Nikoletta Skarlatos | Makeup Department Head |
| Stephanie Barnes | Makeup Artist |
| Carl Fullerton | Makeup Artist |
| Patrice Coleman | Makeup Artist |
| Tracey L. Miller-Smith | Makeup Artist |
| Quintessence Patterson | Makeup Artist |
| Susan Ransom | Makeup Artist |
| Patrick Rofoli | Art Department Coordinator |
| Jon Carlos | Assistant Art Director |
| Jeffrey Schlatter | Construction Coordinator |
| John Berger | Set Designer |
| Danny Brown | Set Designer |
| Leff Lefferts | Sound Effects Editor |
| Dennis S. Sands | Sound Re-Recording Mixer |
| Dennis Leonard | Supervising Sound Editor |
| Jenn Emberly | Animation Supervisor |
| Justin Oliphant | Visual Effects Editor |
| Alisa Simonds | Visual Effects Editor |
| Ryan Tudhope | Visual Effects Producer |
| Hans Bjerno | Helicopter Camera |
| Robert Zuckerman | Still Photographer |
| Daniel George | Set Costumer |
| Sundari Moneek Reid | Set Costumer |
| Sally Wilkerson | Set Costumer |
| Matt Blackshear | Digital Intermediate |
| Des Carey | Digital Intermediate |
| Michael Cioni | Digital Intermediate |
| Peter Cioni | Digital Intermediate |
| Katie Fellion | Digital Intermediate |
| Monique Eissing | Digital Intermediate |
| Peter Oso Snell | Music Editor |
| Dan Marrow | Transportation Coordinator |
| Gary Duncan | Picture Car Coordinator |
| Luca Kouimelis | Script Supervisor |
| Eric Hooge | Location Manager |
| Robert Q. Mathews | Costume Supervisor |
| Alex Madison | Stunts |
| Kim Foscato | Dialogue Editor |
| Pierre Brouard | Dialogue Editor |
| Marilyn McCoppen | Dialogue Editor |
| Daniel Laurie | ADR Supervisor |
| Stuart McCowan | ADR Editor |
| J.P. Jones | Property Master |
| Stephen Urata | Sound Recordist |
| Steve Starkey | Second Unit Director |
| Toby Guidry | Casting Associate |
| Judith Sunga | Casting Associate |
| Cherylanne Martin | Executive Producer |
| Scot Boland | Casting |
| Cherylanne Martin | Unit Production Manager |
| Dana J. Kuznetzkoff | First Assistant Director |
| Greg Gilman | Second Assistant Director |
| Kevin Baillie | Visual Effects Supervisor |
| Heather Kelton | Associate Producer |
| Ryan Chan | Associate Editor |
| Robert Presley | "A" Camera Operator |
| Kevin J. Summers | Boom Operator |
| Michael Lantieri | Special Effects Supervisor |
| Jeannie Epper | Stunts |
| John Gatins | Writer |
| Ashley Rae Trisler | Stunts |
| John Casino | Stunts |
