 | Alex Winter als Ricky Coogan |
 | Randy Quaid als Elijah C. Skuggs |
 | Michael Stoyanov als Ernie |
 | Megan Ward als Julie |
 | Keanu Reeves als Ortiz the Dog Boy |
 | Mr. T als The Bearded Lady |
 | Bobcat Goldthwait als Sockhead |
 | John Hawkes als Cowboy |
 | Jeff Kahn als Nosey |
 | Derek McGrath als Worm |
 | Jaime Cardriche als Toad |
 | Brooke Shields als Skye Daley |
 | William Sadler als Dick Brian |
 | Patti Tippo als Rosie the Pinhead |
 | Lee Arenberg als The Eternal Flame |
 | Alex Zuckerman als Stuey Gluck |
 | Ray Baker als Bill Blazer |
 | Morgan Fairchild als Stewardess |
 | Michael Gilden als Eye |
 | Deep Roy als George Ramirez #3 |
 | Jon M. Chu als Giant Stuey Monster |
 | Gibby Haynes als Cheese Wart |
| Pamela Mant als Nun |
 | Sam Raimi als Crooked Cop (uncredited) |
 | Robert Tapert als Crooked Cop (uncredited) |
| Kevin Kiner | Original Music Composer |
| Vance Hartwell | Makeup Effects |
| Screaming Mad George | Makeup Effects |
| Stephen Chiodo | Producer |
| Jamie Thompson | Director of Photography |
| Alex Winter | Writer |
| Catherine Hardwicke | Production Design |
| Malcolm Campbell | Editor |
| Harry J. Ufland | Producer |
| Mary Jane Ufland | Producer |
| Jene Omens | Director of Photography |
| Tom Stern | Director |
| Alex Winter | Director |
| Tom Stern | Writer |
| Tim Burns | Writer |
| Mary Hidalgo | Casting |
| Bill Corso | Makeup Artist |
| Tom Martinek | I/O Supervisor |
| Kim Hix | Art Direction |
| Brian Kasch | Set Decoration |
| Malissa Daniel | Costume Design |
| Bill Corso | Key Makeup Artist |
| Tony Gardner | Makeup Designer |
| Vance Hartwell | Special Effects Makeup Artist |
| Julie Hewett | Makeup Department Head |
| Steve Johnson | Makeup Effects Designer |
| Margaret Prentice | Makeup Artist |
| Vincent Prentice | Makeup Artist |
| Jim Eustermann | Makeup Artist |
| Screaming Mad George | Makeup Artist |
| Barbara McCullough | Production Manager |
| Marisol Jiménez | Art Department Coordinator |
| Johan le Tenoux | Assistant Art Director |
| Theodore Sharps | Set Designer |
| Robin Solo | Assistant Set Decoration |
| Mark Worthington | Set Designer |
| Gary Gegan | Sound Re-Recording Mixer |
| Kevin Hearst | Sound Editor |
| Michael Hilkene | Supervising Sound Editor |
| Matthew Iadarola | Sound Re-Recording Mixer |
| Eric Lindemann | Sound Effects |
| Brion Paccassi | Sound Recordist |
| Tim Philben | Sound Re-Recording Mixer |
| Jeff Rosen | Sound Editor |
| Wolf Schmidt | Sound Editor |
| John O. Wilde | Sound Editor |
| Kelly Tartan | Sound Effects Editor |
| David Allen | Animation |
| Leslie Huntley | Visual Effects Producer |
| Gene Warren Jr. | Visual Effects Supervisor |
| Bill Sturgeon | Mechanical Designer |
| David Penikas | Mechanical Designer |
| Stephen Chiodo | Animation Director |
| Mette Hansen | Costume Supervisor |
| Screaming Mad George | Special Effects Makeup Artist |
| Dennis Ott | Stunts |
| Debby Porter | Stunts |
| Butthole Surfers | Additional Music |
| Paul Leary | Additional Music |
| Blind Idiot God | Additional Music |
| Pat Romano | Stunts |
