 | Johnny Depp als Inspector Frederick Abberline |
 | Heather Graham als Mary Kelly |
 | Ian Holm als Sir William Gull |
 | Robbie Coltrane als Sergeant Peter Godley |
 | Ian Richardson als Sir Charles Warren |
 | Jason Flemyng als Netley, the Coachman |
 | Katrin Cartlidge als Dark Annie Chapman |
 | Terence Harvey als Benjamin 'Ben' Kidney |
 | Susan Lynch als Liz Stride |
 | Paul Rhys als Dr. Ferral |
 | Lesley Sharp als Kate Eddowes |
 | Estelle Skornik als Ada |
 | Nicholas McGaughey als Officer Bolt |
 | Annabelle Apsion als Polly Nichols |
 | Joanna Page als Ann Crook |
 | Mark Dexter als Albert Sickert / Prince Edward Albert Victor |
 | Danny Midwinter als Constable Withers |
 | Samantha Spiro als Martha Tabram |
 | David Schofield als McQueen |
 | Bryon Fear als Robert Best |
 | Peter Eyre als Lord Hallsham |
 | Cliff Parisi als Mac Bartender |
 | Sophia Myles als Victoria Abberline |
 | Ralph Ineson als Gordie |
 | Amy Huck als Gull's Maid |
 | Rupert Farley als Doss Landlord |
 | Donald Douglas als Hospital Director |
 | John Owens als Marylebone Governor |
| Liz Moscrop als Queen Victoria |
 | Ian McNeice als Coroner Robert Drudge |
 | Steve John Shepherd als Special Branch Constable |
 | Al Hunter Ashton als Stonecutter |
 | Poppy Rogers als Alice Crook |
 | Bruce Byron als Ann Crook's Father |
 | Melanie Hill als Ann Crook's Mother |
 | Andy Linden als Carpenter |
| David Fisher als Carpenter / Letter Writer |
| Gary Powell als Constable #1 |
| Steve Chaplin als Constable #2 |
 | Vincent Franklin als George Lusk |
| Louise Atkins als Bold Hooker |
| Anthony Parker als John Merrick |
 | James Greene als Masonic Governor |
 | Dominic Cooper als Constable #3 |
| Carey Thring als Police Photographer |
| Vladimír Kulhavý als Rag & Bone Man |
| Graham Kent als Records Clerk |
 | Rupert Holliday-Evans als Sailor |
| Simon Harrison als Thomas Bond |
| Paul Moody als Young Doctor |
 | Glen Berry als Young Labourer |
| Charles Parish als Labourer #2 |
| Gerry Grenn als Funeral Minister / Letter Writer |
| Jane Hamsher | Producer |
| Kym Barrett | Costume Design |
| Rafael Yglesias | Screenplay |
| Allen Hughes | Director |
| Sally Osoba | Casting |
| George Bowers | Editor |
| Joyce Gallie | Casting |
| Jindřich Kočí | Art Direction |
| Jill Quertier | Set Decoration |
| Peter Deming | Director of Photography |
| Dan Lebental | Editor |
| Martin Childs | Production Design |
| Terry Hayes | Screenplay |
| Albert Hughes | Director |
| Don Murphy | Producer |
| Trevor Jones | Original Music Composer |
| Tim Gedemer | Sound Designer |
| Vladislav Lew | Scenic Artist |
| Susan Lambie | Script Supervisor |
| Larry Garrison | Publicist |
| Jiří Farkaš | Makeup Artist |
| Stanislava Šlosserová | Set Costumer |
| Roland N. Thai | Sound Effects Editor |
| James Bolt | Sound Re-Recording Mixer |
| Steve Boeddeker | Sound Designer |
| Steven D. Williams | Supervising Sound Editor |
| Tim Wooster | Camera Operator |
| Martin Vačkář | Assistant Art Director |
| Doug Hemphill | Sound Re-Recording Mixer |
| Alicia Stevenson | Foley |
| Paul Massey | Sound Re-Recording Mixer |
| Syd Dutton | Visual Effects |
| Suzi Turnbull | Costume Supervisor |
| Maria Hubackova | Set Costumer |
| Toni-Ann Walker | Hairstylist |
| Jayne Buxton | Hairstylist |
| Beverley Binda | Hairstylist |
| Pavla Lehnerova | Art Department Coordinator |
| Jürgen Vollmer | Still Photographer |
| Petr Konrád | Gaffer |
| Jaroslav Vaculík | Location Manager |
| Steve Artmont | Makeup Artist |
| David Wolowic | First Assistant Sound Editor |
| Bill Taylor | Visual Effects |
| Renata Votrubová | Set Costumer |
| Patty York | Makeup Artist |
| Jiří Farkaš | Hairstylist |
| John Ward | Steadicam Operator |
| Joanna Clack | Visual Effects |
| Sabrina Calley | Set Costumer |
| Alex Gibson | Music Editor |
| Sarah Grispo | Hairstylist |
| Pavel Vokoun | Stunt Coordinator |
| Fumi Mashimo | Animation |
| David Baxa | Set Designer |
| Tim Gomillion | Sound Recordist |
| Dave Kulczycki | Dialogue Editor |
| Vanessa Lapato | ADR Editor |
| Dennis Rogers | Sound Recordist |
| Jim Brookshire | Dialogue Editor |
| Matt Patterson | Sound Recordist |
| Josef Calta | Property Master |
| Amy Robinson | Executive Producer |
| Thomas M. Hammel | Executive Producer |
| Allen Hughes | Executive Producer |
| Albert Hughes | Executive Producer |
| Meg Morman | Casting Assistant |
| Cine Jessy | Casting |
| Brendan Donnison | ADR Voice Casting |
| Vanessa Baker | ADR Voice Casting |
| Gerry Grennell | Dialogue Coach |
| Kamila Skoblova | Stunts |
| Dan Mottl | Stunts |
| Dimo Lipitkovský | Stunts |
| Robert Lahoda | Stunts |
| Blanka Jarosova | Stunts |
| Petr Hnětkovský | Stunts |
| Rebecca Wright | Casting Assistant |
| Alan Moore | Graphic Novel |
| Eddie Campbell | Graphic Novel |
