 | Brendan Fraser als George of the Jungle |
 | Leslie Mann als Ursula Stanhope |
 | Thomas Haden Church als Lyle van de Groot |
 | John Cleese als An Ape Named 'Ape' (voice) |
 | Richard Roundtree als Kwame |
 | Abraham Benrubi als Thor |
 | Holland Taylor als Beatrice Stanhope |
 | John Bennett Perry als Arthur Stanhope |
 | Greg Cruttwell als Max |
 | Kelly Miracco als Betsy |
| Michael Chinyamurindi als N'Dugo |
 | Abdoulaye NGom als Kip |
| Lydell M. Cheshier als Baleto |
| Keith Scott als The Narrator (voice) |
 | Spencer Garrett als Male Guest at Party |
 | Jon Pennell als Male Guest at Party |
 | Lauren Bowles als Ursula's Friend |
| Afton Smith als Ursula's Friend |
 | Samantha Harris als Ursula's Friend |
| Hans Schoeber als Mercenary |
| Alexander Denk als Mercenary |
 | Sven-Ole Thorsen als Mercenary |
| Rodney Louis Johnson als Jailer |
| Peter F. Giddings als TV Weatherman |
| Terilyn Joe als TV Anchor |
| Michel Camus als Cameraman |
| Valerie Perri als TV Reporter |
| Carrie Zanoline als Perfume Lady |
| Garrett Griffin als Fireboat Captain |
| Harve Cook als Bongo Drummer at Dance Studio |
| Richard Elfman als Bongo Drummer at Dance Studio |
| Denise Holland als Dancer |
 | Anne Fletcher als Dancer |
| Kristie Capozzoli als Dancer |
| Sal Vassalo als Dancer |
| Melanie Gage als Dancer |
| Aurorah Allain als Dancer |
 | Diane Mizota als Dancer |
 | Lisa Ratzin als Dancer |
| Joie Shettler als Dancer |
| Sharon Ferrol-Young als Dancer |
 | Tara Nicole Hughes als Dancer |
| Robin Tasha-Ford als Dancer |
| Margo Blas als Caterer |
 | Jake Gentry als Caterer with Tray |
| Tim Glenn als Waiter |
 | Jewel McDonald als Shop Owner |
| Bob Quinn als Party Attendant |
 | Mary Ann Schmidt als Customer at Department Store |
 | Crystal the Monkey als Monkey (uncredited) |
| Sam Weisman | Director |
| Roger Bondelli | Editor |
| Thomas E. Ackerman | Director of Photography |
| Jon Avnet | Producer |
| Stuart H. Pappé | Editor |
| Audrey Wells | Screenplay |
| Dana Olsen | Screenplay |
| David Hoberman | Producer |
| Jordan Kerner | Producer |
| Marc Shaiman | Original Music Composer |
| Amanda Mackey | Casting |
| Cathy Sandrich Gelfond | Casting |
| Lisa Jensen | Costume Design |
| Lou Arkoff | Co-Producer |
| Tim Landry | Visual Effects Supervisor |
| C. Tad Devlin | Executive Producer |
| Stephen Marsh | Production Design |
| Dana Olsen | Story |
| Frederic B. Blankfein | Unit Production Manager |
| C. Tad Devlin | Unit Production Manager |
| K.C. Colwell | First Assistant Director |
| Xochi Blymyer | Second Assistant Director |
| Steve Boyum | Second Unit Director |
| Steve Boyum | Second Unit Director of Photography |
| Phil Adams | Stunt Coordinator |
| Terry Austin | Associate Producer |
| Paula M. Endara | Associate Producer |
| Adam Shankman | Choreographer |
| David M. Haber | Art Direction |
| Mark Zuelzke | Art Direction |
| Kathryn Peters | Set Decoration |
| Greg Wilkinson | Leadman |
| Keith G. Lewis | Costume Supervisor |
| Ben Nye Jr. | Makeup Designer |
| Robert Hallowell II | Hair Designer |
| Heidi Seeholzer | Makeup Artist |
| Voni Hinkle | Hairstylist |
| Douglas Ryan | Camera Operator |
| Terry Anderson | Costumer |
| Steven Hiller | First Assistant "A" Camera |
| Linda Gacsko | Second Assistant "A" Camera |
| Gerrit Dangremond | Steadicam Operator |
| Gerrit Dangremond | "B" Camera Operator |
| Edward A. Gutentag | First Assistant "B" Camera |
| Paul DeMarte | Second Assistant "B" Camera |
| Suzan Lowitz | Script Supervisor |
| David Kelson | Production Sound Mixer |
| Jeffrey A. Humphreys | Boom Operator |
| Steven J. Mikolas | Video Assist Operator |
| Stuart A. Spohn | Chief Lighting Technician |
| Greg Cantrell | Rigging Gaffer |
| Ted Rhodes | Key Grip |
| Bruce Chimerofsky | Best Boy Grip |
| Kurt Young | Dolly Grip |
| Chris Ubick | Property Master |
| Tom Altobello | Assistant Property Master |
| Tracy L. Kettler | Production Coordinator |
| Darrell Woodard | Second Second Assistant Director |
| Les Gobruegge | Set Designer |
| Joe Altadonna | Set Designer |
| John D. Jefferies Sr. | Set Designer |
| Mark Haber | Set Designer |
| David Linck | Unit Publicist |
| Marsha Blackburn | Still Photographer |
| Eddie Lee Voelker | Transportation Coordinator |
| Wayne Roberts | Transportation Captain |
| Kent Beyda | Additional Editor |
| Leigh French | ADR Voice Casting |
| Tim Chau | Supervising Sound Editor |
| Tim Chau | Sound Designer |
| Todd Toon | Supervising Sound Editor |
| Todd Toon | Sound Designer |
| Jim Brookshire | Sound Editor |
| David Kern | Sound Editor |
| Nils C. Jensen | Sound Editor |
| Nancy MacLeod | Sound Editor |
| Doug Jackson | Sound Editor |
| Donald J. Malouf | Sound Editor |
| Albert Gasser | Sound Editor |
| Joe Milner | Sound Editor |
| Jon Title | Sound Editor |
| Kurt Nicholas Forshager | Sound Editor |
| Christopher T. Welch | Supervising ADR Editor |
| Terry Porter | Sound Re-Recording Mixer |
| Mel Metcalfe | Sound Re-Recording Mixer |
| Dean A. Zupancic | Sound Re-Recording Mixer |
| David Orr | Color Timer |
| Nancy Thurston | Stunt Double |
| Jay Ward | Characters |
| John C. Meier | Stunts |
| Steve Blalock | Stunt Double |
| Eddy Donno | Stunts |
| Seth Arnett | Stunt Double |
| John Evanko | Stunts |
| Mark Ginther | Stunts |
| Danny Epper | Stunts |
| Jeff Evans | Stunts |
| Mark Knudsen | Utility Stunts |
| Kevin L. Jackson | Stunts |
| Joey Preston | Stunt Double |
| Patricia M. Peters | Stunt Double |
| Pat McGroarty | Stunts |
| Tim Rigby | Stunt Double |
| J.N. Roberts | Stunts |
| Marlon Rhoden | Stunts |
| George Marshall Ruge | Stunts |
| Pat Romano | Stunts |
| Charlie Sammut | Stunts |
| Michael M. Vendrell | Stunts |
| Guy Manos | Stunts |
