 | Patrick Swayze als Sam Wheat |
 | Demi Moore als Molly Jensen |
 | Whoopi Goldberg als Oda Mae Brown |
 | Tony Goldwyn als Carl Bruner |
 | Vincent Schiavelli als Subway Ghost |
 | Rick Aviles als Willie Lopez |
 | Martina Deignan als Rose |
 | Rick Kleber als Mover |
 | Phil Leeds als Emergency Room Ghost |
 | Armelia McQueen als Oda Mae's Sister |
 | Gail Boggs als Oda Mae's Sister |
 | Stephen Root als Police Sgt. |
 | Alma Beltran als Woman Ghost |
 | Vivian Bonnell als Ortisha |
 | Derek Thompson als Ortisha's Friend |
| Tom Finnegan als Bank Guard |
 | Bruce Jarchow als Lyle Furgeson |
 | Said Faraj als Cab Driver |
 | Dorothy Love Coates als Performer |
| Christopher J. Keene als Elevator Man |
| Susan Breslau als Susan |
 | Macka Foley als Mover |
| John Hugh als Surgeon |
| Sam Tsoutsouvas als Minister |
| Sharon Breslau als Cemetery Ghost |
| Angelina Estrada als Rosa Santiago |
| Thom Curley als Workman in Loft |
| Laura Drake als Policewoman |
| Augie Blunt als Orlando |
| J. Christopher Sullivan als Man Ghost |
 | Charlotte Zucker als Bank Officer |
| Sondra Rubin als Nun |
| Faye Brenner als Nun |
| William Cort als Bank Co-Worker |
| Minnie Summers Lindsey als Apartment Woman |
| Mabel Lockridge als Apartment Woman |
 | Arsenio Hall als Arsenio Hall (uncredited) |
| Stanley Lawrence als Elevator Man |
| Lisa Weinstein | Producer |
| Adam Greenberg | Director of Photography |
| Walter Murch | Editor |
| Clayton Collins | Sound Editor |
| Maurice Jarre | Original Music Composer |
| Jerry Zucker | Director |
| Jane Jenkins | Casting |
| Howard W. Koch | Producer |
| Janet Hirshenson | Casting |
| Ruth Morley | Costume Design |
| Dione Taylor | Hairstylist |
| Ben Nye Jr. | Makeup Artist |
| Stan Tropp | Set Designer |
| Marietta Carter-Narcisse | Makeup Artist |
| Kyle Sweet | Makeup Artist |
| Gary Kudroff | Leadman |
| Steve Maslow | Sound Re-Recording Mixer |
| Walter Murch | Sound Re-Recording Mixer |
| Julia L. Walker | Hairstylist |
| Butch West | Construction Coordinator |
| Mark W. Mansbridge | Art Direction |
| Joe D. Mitchell | Set Decoration |
| Judith Weaver | Animation Supervisor |
| Douglas Greenfield | Dolby Consultant |
| Charlie Clavadetscher | Animation Supervisor |
| Howard Stein | Visual Effects Editor |
| Leslie Shatz | Sound Re-Recording Mixer |
| Jeff Howard | Animation |
| Anthony Stacchi | Animation |
| Martine Tomczyk | Animation |
| Sean Turner | Animation |
| Candace Lewis | Animation |
| Michael Gleason | Visual Effects Editor |
| Gene R. Johnson | Transportation Coordinator |
| Richard Edlund | Visual Effects Supervisor |
| Elizabeth Ziegler | Steadicam Operator |
| Deven Chierighino | Gaffer |
| Katherine Kean | Visual Effects Supervisor |
| Eric Klosterman | Location Manager |
| Dawn J. Jackson | Costume Supervisor |
| Faye Brenner | Script Supervisor |
| John T. Van Vliet | Visual Effects Supervisor |
| Bruce Nicholson | Visual Effects Supervisor |
| Doug Chiang | Visual Effects Art Director |
| Ned Gorman | Visual Effects Producer |
| Mike Benson | Camera Operator |
| Patti Hawn | Unit Publicist |
| Charlie Picerni | Stunt Coordinator |
| Peter Sorel | Still Photographer |
| Gary Davis | Stunt Coordinator |
| Ken Dufva | Foley Artist |
| Laura Graham | Foley Editor |
| Bruce Joel Rubin | Writer |
| Cary Fisher | Second Unit Director of Photography |
| Don Coufal | Boom Operator |
| Lee Haxall | Dialogue Editor |
| David Lee Fein | Foley Artist |
| Greg Curda | Foley Mixer |
| Horst Grandt | Property Master |
| Kathy McCart | Sound Recordist |
| Michael Magill | Dialogue Editor |
| Gary Ritchie | Sound Recordist |
| Bob Baron | ADR Mixer |
| Jeff Wexler | Sound Mixer |
| Michael Tadross | Unit Production Manager |
| Howard W. Koch | Executive Producer |
| Mark Radcliffe | First Assistant Director |
| Joseph Ray | Second Assistant Director |
| Steven-Charles Jaffe | Executive Producer |
| John Hockridge | First Assistant Director |
| Steven-Charles Jaffe | Second Unit Director |
| George Parra | Second Assistant Director |
| Charlie Picerni | Second Unit Director |
| Jane Musky | Production Design |
| Bruce Joel Rubin | Associate Producer |
| Gary McLarty | Stunts |
| Bob K. Cummings | Stunts |
| Shane Dixon | Stunts |
| Sandy Berumen | Stunts |
| Ramiro González | Stunts |
| Peter Hock | Stunts |
| Andy Duppin | Stunts |
| Kym Washington Longino | Stunts |
| Gene McLaughlin | Stunts |
| Harry Madsen | Stunts |
| Jeff Ward | Stunts |
| Dirk Petersmann | Unit Production Manager |
| Allan Graf | Stunt Coordinator |
| John Watson | First Assistant Editor |
