 | Winona Ryder als Susanna Kaysen |
 | Angelina Jolie als Lisa Rowe |
 | Brittany Murphy als Daisy Randone |
 | Clea DuVall als Georgina Tuskin |
 | Elisabeth Moss als Polly Clark |
 | Whoopi Goldberg als Valerie Owens |
 | Vanessa Redgrave als Dr. Wick |
 | Jared Leto als Toby |
 | Jeffrey Tambor als Dr. Melvin Potts |
 | Travis Fine als Nurse John |
 | Angela Bettis als Janet Webber |
 | Jillian Armenante als Cynthia Crowley |
 | Drucie McDaniel als M.G. |
| Christina Myers als Nurse Margie |
 | Mary Kay Place als Barbara Gilcrest |
 | KaDee Strickland als Bonnie Gilcrest |
 | Misha Collins als Tony |
 | Kurtwood Smith als Dr. Crumble |
| David Scott Taylor als Cabby Monty Hoover |
 | Joanna Kerns als Annette |
| Janet Greer als ER Nurse |
| Anne Lewis als Dance Therapist |
| Katie Rimmer als Tiffany |
 | Bruce Altman als Prof. Gilcrest |
 | Ray Baker als Mr. Kaysen |
| Douglas Wick | Producer |
| Kevin Tent | Editor |
| Lisa Loomer | Screenplay |
| James Mangold | Screenplay |
| Anna Hamilton Phelan | Screenplay |
| Mychael Danna | Original Music Composer |
| James Mangold | Director |
| Lisa Beach | Casting |
| Susanna Kaysen | Novel |
| Cathy Konrad | Producer |
| Richard Hoover | Production Design |
| Arianne Phillips | Costume Design |
| Jack N. Green | Director of Photography |
| David Diamond | Boom Operator |
| Gunnar Swanson | Hairstylist |
| Trish Summerville | Assistant Costume Designer |
| Milton Buras | Key Hair Stylist |
| Kathrine Gordon | Hairstylist |
| Julia L. Walker | Hairstylist |
| Janeen Schreyer | Makeup Artist |
| Kathe Swanson | Hair Department Head |
| Jane Galli | Makeup Artist |
| Emanuel Millar | Hairstylist |
| Carol Schwartz | Makeup Department Head |
| Jeff Knipp | Art Direction |
| Ronit Ravich-Boss | Script Supervisor |
| Georgia Kacandes | Co-Producer |
| Susanna Kaysen | Associate Producer |
| Carol Bodie | Executive Producer |
| Winona Ryder | Executive Producer |
| David C. Potter | Leadman |
| Patrick M. Sullivan | Set Designer |
| Mary Finn | Set Designer |
| Jennifer Lamb | Stunt Coordinator |
| David Luckenbach | Camera Operator |
| Bill W. Benton | Sound Re-Recording Mixer |
| Georgia Kacandes | Unit Production Manager |
| Jeffrey J. Haboush | Sound Re-Recording Mixer |
| Dennis McNeill | Color Timer |
| Thomas Milano | Music Editor |
| Maggie Martin | Set Decoration |
| Suzanne Tenner | Still Photographer |
| Joe Everett | Unit Publicist |
| Howell Gibbens | Supervising Sound Editor |
| Michael J. Benavente | Dialogue Editor |
| Hugo Weng | Dialogue Editor |
| George H. Anderson | Sound Effects Editor |
| Linda Grimes | Makeup Artist |
| Diane Maurno | Makeup Artist |
| Ralph Maiers | Visual Effects Supervisor |
