 | Ron Perlman als Hellboy |
 | Selma Blair als Liz Sherman |
 | Doug Jones als Abe Sapien |
 | John Alexander als Johann Krauss / Bethmoora Goblin |
 | Seth MacFarlane als Johann Krauss (voice) |
 | Luke Goss als Prince Nuada |
 | Anna Walton als Princess Nuala |
 | Jeffrey Tambor als Tom Manning |
 | John Hurt als Trevor Bruttenholm |
 | James Dodd als Johann Krauss |
 | Brian Steele als Wink / Cronie / Spice Shop Troll / Cathedral Head / Fragglewump |
 | Andrew Hefler als Agent Flint |
 | Iván Kamarás als Agent Steel |
 | Mike Kelly als Agent Marble |
| Jeremy Zimmermann als Auctioneer |
 | Santiago Segura als Distinguished Buyer |
 | Roy Dotrice als King Balor |
 | Aidan Cook als Two-Headed Shop Owner |
| Jeanne Mockford als Bag Lady |
 | Montse Ribé als Young Hellboy |
 | Ferenc Elek als Fat Slob |
 | Alex McSweeney als Policeman |
| Justin Pierre als Policeman |
| Matthew O'Toole als Limb Vendor |
| Jamie Wilson als Cat Vendor |
 | Clive Llewellyn als Tadpole Vendor |
| Sándor Svigelj als Bagpipe Player |
 | Brian Herring als Silkard / Fish Vendor |
| Pálma Pásztor als Mummy Vendor |
 | Jimmy Kimmel als Jimmy Kimmel |
| Tim Flavin als Newscaster |
| Belinda Henley als Newscaster |
 | Blake Perlman als Newscaster |
 | Matt Rippy als Newscaster |
 | Judit Viktor als Lady with Dog |
 | Szonja Oroszlán als Woman with Baby |
 | Michael Mehlmann als Auction Bidder Man |
| Todd Williams als Auction Bidder Man |
 | Beatrice Zentai als Auction Bidder Woman |
 | Peter Horkay als Steward |
 | Richard Rifkin als TV Pundit |
 | Guillermo del Toro als Creature Vocals (voice) (uncredited) |
| Tim Larsen als Street Thug (uncredited) |
| Gavin McKenzie als Auction Room Steward (uncredited) |
 | Julia Papp als Reporter (uncredited) |
| Guillermo del Toro | Director |
| Guillermo del Toro | Screenplay |
| Danny Elfman | Original Music Composer |
| Lawrence Gordon | Producer |
| Lloyd Levin | Producer |
| Mike Richardson | Producer |
| Zsolt Csutak | Casting |
| Jeremy Zimmermann | Casting |
| Sammy Sheldon | Costume Design |
| Guillermo Navarro | Director of Photography |
| Mike Mignola | Comic Book |
| Mike Mignola | Story |
| Mike Mignola | Co-Executive Producer |
| Géza Kovács | Stunts |
| Montse Ribé | Makeup Effects Designer |
| Mike Elizalde | Makeup Effects Designer |
| Thomas Floutz | Makeup Effects Designer |
| Ildikó Szücs | Stunts |
| Gáspár Szabó | Stunts |
| Ákos Sinkó | Stunts |
| Oliver Simor | Stunt Double |
| Laszlo Ramon | Stunts |
| Gábor Piroch | Stunt Double |
| Jan Petřina | Stunt Double |
| Miklós Pardányi | Stunts |
| Domonkos Párdányi | Stunt Coordinator |
| Domonkos Párdányi | Stunt Double |
| Ferenc Novinecz | Stunts |
| Bonnie Morgan | Stunts |
| Attila Mora | Stunts |
| László Medriczky | Stunts |
| Zsolt Viktor Magyari | Stunts |
| Akos Lenkei | Stunts |
| Balázs Lengyel | Stunts |
| Norbert Kovács | Stunts |
| József Kovalik | Stunts |
| László Kósa | Stunts |
| István Koleszár | Stunts |
| Lou Horvath | Stunts |
| Gábor Hortobágyi | Stunts |
| Gergö Horpácsi | Stunts |
| Justin Rodgers Hall | Stunts |
| Kinga Kosá-Gavalda | Stunts |
| Gao Xiang | Stunts |
| Balázs Farkas | Stunts |
| Gábor Duck | Stunts |
| Erika Cziráky | Stunts |
| Rhye Copeman | Stunts |
| Mark Chapman | Stunts |
| Nick Brett | Stunts |
| Chan Man-Ching | Fight Choreographer |
| Sándor Boros | Stunts |
| Xia Bin | Stunt Double |
| Ferenc Berecz | Stunts |
| Henriett Andrejszky | Stunts |
| Henriett Andrejszky | Stunt Double |
| Bradley James Allan | Stunt Coordinator |
| Harry Szovik | Set Decoration |
| Zsuzsa Mihalek | Set Decoration |
| Elli Griff | Set Decoration |
| Peter Francis | Supervising Art Director |
| Judit Varga | Art Direction |
| Mark Swain | Art Direction |
| Csaba Stork | Art Direction |
| Paul Laugier | Art Direction |
| John Frankish | Art Direction |
| Anthony Caron-Delion | Art Direction |
| Stephen Scott | Production Design |
| Bernat Vilaplana | Editor |
| Sam Conway | Special Effects Technician |
| Chris Symes | Executive Producer |
| John Swallow | Co-Producer |
| Kathy Nelson | Music Supervisor |
| Michael J. Wassel | Visual Effects Supervisor |
| Jo Burn | Unit Production Manager |
| Cliff Lanning | First Assistant Director |
| Miklós Tóth | Production Manager |
| Jaromír Šedina | "A" Camera Operator |
| Jaromír Šedina | Steadicam Operator |
| Juan Leiva | First Assistant "A" Camera |
| Gergely Hajba | Second Assistant "A" Camera |
| László Bille | "B" Camera Operator |
| Zsolt Fehér | First Assistant "B" Camera |
| Ádám Wallner | Second Assistant "B" Camera |
| Nyika Jancsó | "C" Camera Operator |
| Arne Kaupang | Animation |
| Wayne D. Barlowe | Creature Design |
| Nicolas Becker | Foley Artist |
| Harry Barnes | Foley Editor |
| Julie Altus | ADR Recordist |
| Christopher Barnett | Sound Designer |
| Mike Prestwood Smith | Sound Re-Recording Mixer |
| Peter Gleaves | ADR Mixer |
| Peter Burgis | Foley Artist |
| Andie Derrick | Foley Artist |
| Ed Colyer | Foley Mixer |
| Bryan Bowen | Sound Designer |
| Dominique Devoucoux | Foley Editor |
| James Moriana | Foley Artist |
| Jack Stew | Foley Artist |
| Mark Taylor | Sound Re-Recording Mixer |
| Christopher Wilson | Foley Editor |
| Philippe Amouroux | Foley Recordist |
| Nick Foley | ADR Mixer |
| Chris Lyons | Special Effects Makeup Artist |
| Tim Larsen | Special Effects Makeup Artist |
| Ian Morse | Special Effects Makeup Artist |
| Bart Mixon | Special Effects Makeup Artist |
| Deborah Jarvis | Makeup Designer |
| Brendon Heath | Hairstylist |
| Mélanie Gerbeau-Lainé | Hairstylist |
| Mike Elizalde | Special Effects Makeup Artist |
| Norman Cabrera | Prosthetics Sculptor |
| Nigel Booth | Special Effects Makeup Artist |
| Beverley Binda | Makeup Artist |
| Szandra Bíró | Makeup Artist |
| Matthew Sharp | Assistant Director |
