 | Derek Jacobi als Nicodemus (voice) |
 | Elizabeth Hartman als Mrs. Brisby (voice) |
 | Arthur Malet als Mr. Ages (voice) |
 | Dom DeLuise als Jeremy (voice) |
 | Hermione Baddeley als Auntie Shrew (voice) |
 | Shannen Doherty als Teresa (voice) |
 | Wil Wheaton als Martin (voice) |
 | Jodi Hicks als Cynthia (voice) |
| Ina Fried als Timothy (voice) |
 | John Carradine als Great Owl (voice) |
 | Peter Strauss als Justin (voice) |
 | Paul Shenar als Jenner (voice) |
| Tom Hatten als Farmer Fitzgibbons (voice) |
 | Lucille Bliss als Mrs. Fitzgibbons (voice) |
 | Aldo Ray als Sullivan (voice) |
| Norbert Auerbach als Councilman 1 (voice) |
| Dick Kleiner als Councilman 2 (voice) |
| Charles Champlin als Councilman 3 (voice) |
| Joshua Lawrence als Billy Fitzgibbons (voice) |
| Don Bluth | Director |
| Don Bluth | Screenplay |
| Will Finn | Screenplay |
| Gary Goldman | Screenplay |
| Robert C. O'Brien | Novel |
| John Pomeroy | Screenplay |
| Don Bluth | Producer |
| Gary Goldman | Producer |
| Rich Irvine | Executive Producer |
| John Pomeroy | Producer |
| James L. Stewart | Executive Producer |
| Jerry Goldsmith | Original Music Composer |
| Jeffrey C. Patch | Editor |
| Diann Landau | Animation |
| Buck Lewis | Character Designer |
| Don Bluth | Visual Development |
| David M. Horton | Sound Effects Editor |
| Rick Kline | Sound Re-Recording Mixer |
| Donald O. Mitchell | Sound Re-Recording Mixer |
| Dorse A. Lanpher | Visual Effects Supervisor |
| Fred Craig | Visual Effects Director |
| Don Bluth | Animation Director |
| Gary Goldman | Animation Director |
| John Pomeroy | Animation Director |
| Skip Jones | Animation |
| Vera Pacheco | Animation |
