 | Taraji P. Henson als Katherine G. Johnson |
 | Octavia Spencer als Dorothy Vaughan |
 | Janelle Monáe als Mary Jackson |
 | Kevin Costner als Al Harrison |
 | Kirsten Dunst als Vivian Mitchell |
 | Jim Parsons als Paul Stafford |
 | Mahershala Ali als Jim Johnson |
 | Glen Powell als John Glenn |
 | Ariana Neal als Joylette Johnson |
 | Saniyya Sidney als Constance Johnson |
 | Zani Jones Mbayise als Kathy Johnson |
 | Donna Biscoe als Joylette Coleman |
 | Olek Krupa als Karl Zielinski |
 | Aldis Hodge als Levi Jackson |
 | Kimberly Quinn als Ruth |
 | Frank Hoyt Taylor als Judge |
 | Lidya Jewett als Young Katherine |
 | Karan Kendrick als Younger Joylette |
 | Jaiden Kaine als Joshua Coleman |
 | Kurt Krause als Sam Turner |
 | Ken Strunk als Jim Webb |
 | Selah Kimbro Jones als Carolyn Marie Jackson |
 | Tre Stokes als Levi Jackson Jr. |
 | Corey Mendell Parker als Howard Vaughan |
 | Ashton Tyler als Leonard Vaughan |
 | Alkoya Brunson als Kenneth Vaughan |
 | Ron Clinton Smith als White Cop |
 | Gregory Alan Williams als Marion Smithson |
 | Maria Howell als Ms. Sumner |
 | Arnell Powell als Professor Graves |
 | Crystal Lee Brown als Bernie |
 | Tequilla Whitfield als Eleanor |
 | Dane Davenport als Alan Shepard |
 | Evan Holtzman als Deke Slayton |
| Travis Smith als Scott Carpenter |
 | Scott Michael Morgan als Bill Calhoun |
 | Chris Cavalier als IBM Technician |
 | Robert G. McKay als Pastor Ayres |
 | Rhoda Griffis als White Librarian |
 | Karen Wheeling Reynolds als Court Clerk |
 | Kate Kneeland als Court Clerk |
 | Joe Knezevich als Wind Tunnel PA Announcer |
 | Paul Ryden als TV Reporter at Cape Canaveral |
 | John Atwood als Newscaster |
 | Jon Edwin Wright als Newscaster |
 | Wilbur Fitzgerald als Senator Patrick |
| Michael Hartson als Night School Professor |
 | Bob Jennings als Navy Officer |
 | Gary Weeks als Reporter at Press Conference |
 | Afemo Omilami als Man Outside Store |
 | Cullen Moss als Mission Control Commander |
 | Amy Tipton als Woman Crying |
 | Elijah Everett als Man Crying |
 | Andre Pushkin als Russian Scientist |
 | Randall Newsome als Russian Scientist |
| Joe Hardy Jr. als Gordon Cooper |
 | Howie Johnson als Library Security Guard |
 | David Kallaway als NASA Security Guard |
| Addison Rose Melfi als Addie Marcus |
| Paige Nicollette als Eunice (uncredited) |
| Theodore Melfi | Director |
| Wynn Thomas | Production Design |
| Peter Teschner | Editor |
| Jeremy Woolsey | Art Direction |
| Renee Ehrlich Kalfus | Costume Design |
| Missy Parker | Set Decoration |
| Allison Schroeder | Screenplay |
| Theodore Melfi | Screenplay |
| Donna Gigliotti | Producer |
| Peter Chernin | Producer |
| Jenno Topping | Producer |
| Pharrell Williams | Producer |
| Theodore Melfi | Producer |
| Margot Lee Shetterly | Book |
| Ivana Lombardi | Executive Producer |
| Renee Witt | Executive Producer |
| Mimi Valdes | Executive Producer |
| Kevin Halloran | Executive Producer |
| Margot Lee Shetterly | Executive Producer |
| Jamal Daniel | Executive Producer |
| Mandy Walker | Director of Photography |
| Victoria Thomas | Casting |
| Chloe Lipp | Art Department Coordinator |
| Jasmine Alexia Jackson | Art Department Assistant |
| Danny Brown | Assistant Art Director |
| Gail Hunter | Script Supervisor |
| Greg Tresan | Animal Coordinator |
| Richard Ford | Music Editor |
| Catherine Wilson | Music Editor |
| Paula Elins | Assistant Costume Designer |
| Valerie Zielonka | Costume Supervisor |
| Fatima Stripling | Set Costumer |
| Meredith Coats | Set Costumer |
| Kendra L. Patterson | Set Costumer |
| Rebecca Napier White | Set Costumer |
| Dustin Angus | Key Costumer |
| Cha Blevins | Key Costumer |
| Ellen Semones | Key Costumer |
| Bonnie Grisan | Casting Associate |
| Micky Froehlich | Camera Operator |
| Louie Northern | Drone Operator |
| Jason Ellson | Steadicam Operator |
| Hopper Stone | Still Photographer |
| Chris Culliton | Gaffer |
| Chad Schroeder | Rigging Gaffer |
| Justin Yardley Jones | Rigging Grip |
| Scott Sealock | Rigging Grip |
| Edward Young | Rigging Grip |
| Chris Birdsong | Key Grip |
| Sean Pollack | CG Supervisor |
| Mark R. Byers | Special Effects Supervisor |
| Rif Dagher | VFX Supervisor |
| Jason Sanford | Visual Effects Producer |
| Stefan Andersson | Visual Effects Supervisor |
| Chris LeDoux | Visual Effects Supervisor |
| Susan Dawes | ADR Supervisor |
| Derek Vanderhorst | Sound Designer |
| Wayne Lemmer | Sound Designer |
| Phil Barrie | Sound Effects Editor |
| Erin Michael Rettig | Sound Engineer |
| Brian Bair | Sound Re-Recording Mixer |
| Andy Nelson | Sound Re-Recording Mixer |
| Derek Vanderhorst | Sound Re-Recording Mixer |
| Wayne Lemmer | Supervising Sound Editor |
| Melissa Forney | Hair Department Head |
| Beverly Jo Pryor | Makeup Department Head |
| Yolanda Sheridan | Key Makeup Artist |
| Quintessence Patterson | Makeup Artist |
| Selena Evans-Miller | Makeup Artist |
| Thomas Kuo | Digital Intermediate |
| Hans Zimmer | Original Music Composer |
| Pharrell Williams | Original Music Composer |
| Benjamin Wallfisch | Original Music Composer |
| R.J. Kizer | Dialogue Editor |
| David Betancourt | ADR Mixer |
| Matthew Nicolay | Sound Mixer |
| Peter Persaud | Foley Recordist |
| Steve Baine | Foley Artist |
| Luke Schwarzweller | Sound Recordist |
| Carol Francoso | Scenic Artist |
| Greg Harmon | Propmaker |
| Lawrence Heap | Leadman |
| Nathan Krochmal | Set Designer |
| Jason Sweers | Graphic Designer |
| Roman Weaver | Carpenter |
| Angie Woodard | Assistant Property Master |
| Marc Casey | Second Assistant "B" Camera |
| Linton Flowers | Best Boy Grip |
| Jarek Gorczycki | Best Boy Electric |
| Doug Harmes | Electrician |
| Matthew Kelly Jackson | Second Assistant "A" Camera |
| Jonathan McKeown | Electrician |
| Larry Nielsen | First Assistant "A" Camera |
| Louie Northern | Drone Pilot |
| Tony Rivetti Sr. | First Assistant "B" Camera |
| Eric Pagdin | Key Hair Stylist |
| Ashunta Sheriff | Key Makeup Artist |
| Al Watson | Hairstylist |
| Sasha Veneziano | Production Supervisor |
| Gary Marcus | First Assistant Director |
| Helen Luttrell | Dialogue Editor |
| Chris Navarro | ADR Mixer |
| Christine Sirois | ADR Recordist |
| Mark Wilkening | ADR Mixer |
| Keith Adams | Stunt Coordinator |
| Raven-Danielle Baker | Stunts |
| Kirk A. Jenkins | Stunts |
| Bethany Levy | Stunts |
| Nathaniel Perry | Stunts |
| Brandon M. Shaw | Stunts |
| Paul E. Short | Stunts |
| Greg Sproles | Stunts |
| Leah Gunter | Assistant Editor |
| Wes Hagan | Location Manager |
| David J. Krystal | Orchestrator |
| Sean Bankhead | Choreographer |
| Wren Boney | Set Medic |
| Chip Clanton | Production Coordinator |
| Denise Woods | Dialect Coach |
| Jason Inman | Second Assistant Director |
| Craig Henighan | Sound Designer |
