 | Rupert Friend als Agent 47 |
 | Zachary Quinto als John Smith |
 | Hannah Ware als Katia |
 | Emilio Rivera als Fabian |
 | Rolf Kanies als Dr. Delriego |
 | Thomas Kretschmann als Le Clerq |
 | Dan Bakkedahl als Sanders |
 | Ciarán Hinds als Litvenko |
 | Mona Pirzad als Katia's Mother |
| William E. Morris als Surveillance Tech |
 | Michaela Caspar als Hall of Records Clerk |
 | Jerry Hoffmann als Franco |
 | AngelaBaby als Diana |
 | Jürgen Prochnow als Tobias |
| Charlene Beck als Tenement Woman |
| Michael Bornhütter als Berlin Police Officer #1 |
| Melissa Broughton als Gardens by the Bay Woman with Baby |
 | Nils Brunkhorst als Syndicate Doctor |
| Alvin Chan als Gardens by the Bay Man #1 |
| Manuel Depta als Russian Soldier |
| Andrew DiBartolomeo als Gardens by the Bay Man #2 |
| Georg Ebinal als Salzburg Syndicate Operator Driver |
| Jörg Ellmer als Ruassian Soldier |
| Waye Leon Goh als Gardens by the Bay Man #3 |
| Matthias Günther als Marine Task Force |
| Jesse Hergt als Young Agent 47 |
| Florian Hotz als Lead Syndicate Operator |
 | Sebastian Hülk als Garad |
| Michael Knese als Embassy Marine #2 |
| Felix Koch als Salzburg Syndicate Operator Driver #1 |
 | Alrik Kreemke als Salzburg Syndicate Operator #1 |
| Daniel Michael Nelson als Robert - Kid in Elevator |
| Peter Paes als Salzburg Syndicate Operator Driver #2 |
 | Helena Pieske als Young Katia |
| Markus Ranglack als Russian Agent / Driver |
| Kira Smidt als Baby Katia |
 | Daniel Stockhorst als John Smith's G-Wagon Driver |
 | Johannes Suhm als Young Litvenko |
| Eskindir Tesfay als Marine #2 |
| Asuka Tovazzi als Berlin Police Officer #2 |
 | Janice Koh Yu-Mei als Robert's Mum |
| Michael Corcoran als Robert's Dad |
| Melanie Benna als Businesswoman (uncredited) |
 | David Brückner als Syndicate International Hacker (uncredited) |
| Dennis Heath als Bystander in Action Scene (uncredited) |
| Jessica Lois als Woman in Subway Station (uncredited) |
| Chris Theisinger als S.I. Tactical Ops (uncredited) |
 | Joe Tödtling als Marine (uncredited) |
| Tomas Jester als Tenement Man |
 | Gillian Tan als Woman in Airport (uncredited) |
| Ted Caplan | Music Editor |
| Alex Young | Producer |
| Charles Gordon | Producer |
| Adrian Askarieh | Producer |
| Skip Woods | Screenplay |
| Michael Finch | Screenplay |
| Fran Borgia | Line Producer |
| Aleksander Bach | Director |
| Skip Woods | Producer |
| Óttar Guðnason | Director of Photography |
| Nicolas De Toth | Editor |
| Denise Chamian | Casting |
| Sebastian T. Krawinkel | Production Design |
| Sabine Engelberg | Art Direction |
| Bryce Tibbey | Art Direction |
| Yeşim Zolan | Set Decoration |
| Bina Daigeler | Costume Design |
| Robert Blasi | Art Department Coordinator |
| Adolf Wojtinek | Special Effects Coordinator |
| Mario Uy | Armorer |
| Lutz Zeidler | Armorer |
| Liz Ludwitzke | Casting Associate |
| Daniela Backes | Assistant Costume Designer |
| Dietke Brandt | Set Costumer |
| Zoe Simijonovic | Script Supervisor |
| Sharon Martin | Hair Designer |
| Valeska Schitthelm | Hairstylist |
| Jenna Smith | Hairstylist |
| Irina Tübbecke-Bechem | Makeup Artist |
| Dollei Seah | Makeup Artist |
| Christine Herzog | Wigmaker |
| Tim Maxwell | Sound Recordist |
| Ben Barker | Sound Designer |
| Glenn Freemantle | Sound Designer |
| Andrew Caller | Sound Re-Recording Mixer |
| Brendan Nicholson | Sound Re-Recording Mixer |
| Glenn Freemantle | Supervising Sound Editor |
| Claudius Rauch | Special Effects Supervisor |
| Florian Emmerich | Camera Operator |
| Sebastian Meuschel | Camera Operator |
| Adrian Cranage | Camera Operator |
| Norwin Hatschbach | Helicopter Camera |
| Tilman Büttner | Steadicam Operator |
| Reiner Bajo | Still Photographer |
| Stefan Mohn | Still Photographer |
| Björn Susen | Gaffer |
| Dietmar Haupt | Rigging Gaffer |
| Duane Manwiller | Second Unit Cinematographer |
| Skip Woods | Story |
| Daniel Alter | Executive Producer |
| Michael Hendrickson | Executive Producer |
| Marco Mehlitz | Executive Producer |
| Arno Neubauer | Line Producer |
| Mike Wiluan | Co-Producer |
| Freddie Yeo | Co-Producer |
| Little Suzy Yeo | Line Producer |
| Marco Beltrami | Original Music Composer |
| Stephan O. Gessler | Supervising Art Director |
| Jon Valera | Fight Choreographer |
| Chris O'Hara | Stunt Coordinator |
| Volkhart Buff | Stunt Coordinator |
| Jonathan Eusebio | Stunt Coordinator |
| Ralf Häger | Stunt Coordinator |
| Tamar Aviv | Makeup Effects |
| David Leitch | Action Director |
| Chad Stahelski | Action Director |
| Thomas Hacikoglu | Stunts |
| Tanner Foust | Stunt Driver |
| Stefan Müller | Helicopter Camera |
| Matthew Wells | Post Production Coordinator |
| Phong Giang | Stunts |
| Todd Harris | Storyboard Artist |
