 | Jason Bateman als Nick Hendricks |
 | Charlie Day als Dale Arbus |
 | Jason Sudeikis als Kurt Buckman |
 | Kevin Spacey als Dave Harken |
 | Jennifer Aniston als Julia Harris |
 | Colin Farrell als Bobby Pellitt |
 | Jamie Foxx als Motherfucker Jones |
 | Donald Sutherland als Jack Pellit |
 | P.J. Byrne als Kenny Sommerfeld |
 | Julie Bowen als Rhonda Harken |
 | Lindsay Sloane als Stacey |
 | Wendell Pierce als Detective Hagan |
 | Ron White als Detective Samson |
 | John Francis Daley als Carter |
 | Meghan Markle als Jamie |
 | Steve Wiebe als Thomas |
 | Michael Albala als Mr. Anderton |
| Jennifer Hasty als Kurt's Co-Worker |
 | Reginald Ballard als Kurt's Co-Worker |
 | George Back als Kurt's Co-Worker |
 | Barry Livingston als Kurt's Co-Worker |
| Celia Finkelstein als Margie Emerman |
 | Diana Toshiko als Bobby's Girl |
 | Carla Maria Cadotte als Bobby's Girl |
 | Scott Rosendall als Hank Preston |
 | Dave Sheridan als Bartender (Bradford's Bar) |
 | Chad L. Coleman als Bartender (Dive Bar) |
 | Ioan Gruffudd als Wetwork Man |
 | Brian George als Atmanand |
 | Peter Breitmayer als Pharmacist |
 | Isaiah Mustafa als Officer Wilkens |
 | Jimm Giannini als Harken Party Guest |
 | Bob Newhart als Lou Sherman |
 | Seth Gordon als Ralph Peterberg |
 | Christina Blevins als Cute Girl at Bar (uncredited) |
| Seth Gordon | Director |
| Brett Ratner | Producer |
| John Francis Daley | Screenplay |
| John Johnson | Still Photographer |
| Jonathan Goldstein | Screenplay |
| Jay Stern | Producer |
| Michael Markowitz | Screenplay |
| Carol Ramsey | Costume Design |
| Deborah La Mia Denaver | Makeup Department Head |
| Peter Teschner | Editor |
| Sarah Katzman | Casting |
| Shepherd Frankel | Production Design |
| Paul Graff | Visual Effects Supervisor |
| Mike Medina | Construction Coordinator |
| Joyce Kogut | Costume Supervisor |
| Deidra Dixon | Hairstylist |
| Jeremy Hays | Special Effects Coordinator |
| Jay Pelissier | Art Direction |
| Jamie Kelman | Makeup Artist |
| Lisa Beach | Casting |
| David Hennings | Director of Photography |
| Jan Pascale | Set Decoration |
| Chris McMillan | Hairstylist |
| LaLette Littlejohn | Makeup Artist |
| Sara Ghaffar | Art Department Coordinator |
| Angela Levin | Makeup Artist |
| Magdalena Wolf | Visual Effects Producer |
| Ellen Falguiere | Assistant Costume Designer |
| Patricia DeHaney | Key Hair Stylist |
| Mychael Bates | Property Master |
| John Cheng | Co-Producer |
| Elmo Weber | Supervising Sound Editor |
| Elmo Weber | Sound Re-Recording Mixer |
| Alexa Alden | Script Supervisor |
| Denny Caira | Transportation Coordinator |
| Christopher Lennertz | Original Music Composer |
| Jeff Wexler | Production Sound Mixer |
| Dana Sano | Music Supervisor |
| Todd Bozung | Music Editor |
| Michael Markowitz | Story |
| Darin Rivetti | First Assistant Director |
| Joe Lemola | Sound Effects Editor |
| Brad Sherman | Sound Re-Recording Mixer |
| Marc Glassman | Sound Effects Editor |
| Alasdair Boyd | Location Manager |
| Diana Pokorny | Unit Production Manager |
| Christopher T. Welch | Dialogue Editor |
| Russell Farmarco | Dialogue Editor |
| Cameron Steenhagen | Dialogue Editor |
| David Williams | Dialogue Editor |
| Todd Durboraw | Second Assistant Camera |
| James R. Tynes | Chief Lighting Technician |
| John 'Fest' Sandau | Assistant Chief Lighting Technician |
| Gregory W. Smith | Camera Operator |
| Don Coufal | Boom Operator |
| Lamarr Gray | Rigging Gaffer |
| Chad Rivetti | First Assistant Camera |
| Rodney Sandoval | Second Assistant Camera |
| Sean Graham | Stunt Coordinator |
| Don Duffield | First Assistant Camera |
| Kim Marks | Camera Operator |
| Jeremy Reisig | Second Second Assistant Director |
| Helen Medrano | Production Accountant |
| Mary Rohlich | Co-Producer |
| Corey Michael Eubanks | Stunts |
| Samuel J. Brown | Executive Producer |
| Lori Seaman | Stunts |
| Michael Disco | Executive Producer |
| Toby Emmerich | Executive Producer |
| Rick Avery | Stunts |
| Richard Brener | Executive Producer |
| Laura Albert | Stunts |
| Richard Burden | Stunts |
| Diana Pokorny | Executive Producer |
| John Rickard | Co-Producer |
| Chris Regan | Color Timer |
| Natasha Leonnet | Digital Intermediate Colorist |
| Robert E. Phillips | Digital Intermediate Producer |
| Martha Pike | Digital Intermediate Editor |
| Catherine Harper | Foley Artist |
| Christopher Moriana | Foley Artist |
| Darrin Mann | Foley Mixer |
| Howard London | ADR Mixer |
| Eliza Pollack Zebert | ADR Supervisor |
| Matthew P. Hanson | Assistant Sound Editor |
| Michelle Morrissey | Production Supervisor |
| Jay Vinitsky | Post Production Supervisor |
| Calla Klessig | Assistant Art Director |
| Louise Del Araujo | Leadman |
| Conny Boettger-Marinos | Set Designer |
| Robert Hatfield | Digital Imaging Technician |
| Stan Harrison | Video Assist Operator |
| Cary Weitz | Utility Sound |
| Kerri Smeltzer | Production Office Coordinator |
| Francesco Tignini | Second Assistant Director |
| Herb Ault | Key Grip |
| Shannon Deats | Best Boy Grip |
| Tim Christie | Dolly Grip |
| Richard 'Rocky' Nichols | Assistant Property Master |
| Josue Rodriguez | Assistant Property Master |
| Kelcey Fry | Makeup Artist |
| Jason M. Moore | Set Costumer |
| Jamelle Flowers | Set Costumer |
| Christine Jordan | Set Costumer |
| Erin Lenk | Set Costumer |
| Nina Hallworth | Costumer |
| Clare Hallworth | Costumer |
| Steve Borgese | Greensman |
| Matthew Kern Atzenhoffer | Set Dresser |
| Alan Burg | Set Dresser |
| Connie Gackenbach | Set Dresser |
| Deborah Harman | Set Dresser |
| Nina Kawasaki | First Assistant Editor |
| Lauren Connelly | Assistant Editor |
| Claire Raskind | Unit Publicist |
| Dave Kasubowski | Craft Service |
| Mike Shannon | Transportation Captain |
| Tyler W. Gaisford | Picture Car Coordinator |
| Andrew Kinney | Orchestrator |
| Libby Umstead | Music Coordinator |
| Scott Wilder | Stunts |
| Matthew Taylor | Stunts |
| Rich Rutherford | Stunts |
| Jimmy Romano | Stunts |
| Chuck Picerni Jr. | Stunts |
| Robert Nagle | Stunts |
| Tom McComas | Stunts |
| Tony Lazzara | Stunts |
| Les Larson | Stunts |
| Hubie Kerns Jr. | Stunts |
| Steve Kelso | Stunts |
| Keii Johnston | Stunts |
| Buddy Joe Hooker | Stunts |
| Mickey Giacomazzi | Stunts |
| Brent Fletcher | Stunts |
| John T. Cypert | Stunts |
| Charles Croughwell | Stunts |
| Gary Baxley | Stunts |
| Craig Baxley Jr | Stunts |
| Matt Baker | Stunts |
| Mike Avery | Stunts |
| Gregory J. Barnett | Stunts |
| Chris Palermo | Stunt Driver |
| Joe Bucaro III | Stunt Driver |
| Mark Norby | Stunt Driver |
