 | Don Cheadle als Paul Rusesabagina |
 | Sophie Okonedo als Tatiana Rusesabagina |
 | Nick Nolte als Colonel Oliver |
 | Fana Mokoena als General Bizimungu |
 | Joaquin Phoenix als Jack Daglish |
 | Jean Reno als Sabena Airlines President, Mr. Tillens |
 | Desmond Dube als Dube |
 | Ofentse Modiselle als Roger Rusesabagina |
 | Mathabo Pieterson als Diane Rusesabagina |
 | Hakeem Kae-Kazim als George Rutaganda |
 | Tony Kgoroge als Gregoire |
 | Lebo Mashile als Odette |
 | Antonio David Lyons als Thomas Mirama |
 | Leleti Khumalo als Fedens |
 | Neil McCarthy als Jean Jacques |
| Mabutho 'Kid' Sithole als Head Chef |
| Jeremiah Ndlovu als Old Guard |
 | Mosa Kaiser als Elys Rusesabagina |
 | David O'Hara als David |
 | Lennox Mathabathe als Peter |
| Mothusi Magano als Benedict |
 | Simo Mogwaza als Hutu Captain |
 | Cara Seymour als Pat Archer |
 | Roberto Citran als Priest |
 | Mduduzi Mabaso als Hutu Lieutenant |
 | Harriet Lenabe als Alice the Waitress |
 | Xolani Mali als Policeman |
 | Rosie Motene als Receptionist |
| Johnny Breedt | Production Design |
| Keir Pearson | Screenplay |
| A. Kitman Ho | Producer |
| Robert Fraisse | Director of Photography |
| Martin Russell | Original Music Composer |
| Terry George | Author |
| Richard Pagano | Casting |
| Terry George | Director |
| Tony Burrough | Production Design |
| Naomi Geraghty | Editor |
| Moonyeenn Lee | Casting |
| Andrea Guerra | Original Music Composer |
| Rupert Gregson-Williams | Original Music Composer |
| Keir Pearson | Author |
| Terry George | Screenplay |
| Terry George | Producer |
| Sally French | Line Producer |
| Suzanne Stokes-Munton | Hair Department Head |
| Sarah Trevis | Casting |
| Tania Brooke | Makeup Artist |
| Vanessa Baker | Casting |
| Emma MacDevitt | Art Direction |
| Ruy Filipe | Costume Design |
| Alistair Hopkins | Post Production Supervisor |
| Roberto Cicutto | Executive Producer |
| Graham Press | Stunt Coordinator |
| Brendan Donnison | Casting |
| Belinda Kruger | Casting Associate |
| Lisa Vick | Script Supervisor |
| Nicci Van Niekerk | Assistant Editor |
| Vincent G. Cox | Camera Operator |
| Kenny Becker | Color Timer |
| Blid Alsbirk | Still Photographer |
| Paula Jalfon | Unit Production Manager |
| Suzanne Belcher | Makeup Department Head |
| Duncan Reid | Executive Producer |
| Hal Sadoff | Executive Producer |
| Martin Katz | Executive Producer |
| Sam Bhembe | Executive Producer |
| Francesco Melzi d'Eril | Executive Producer |
| Keir Pearson | Co-Executive Producer |
| Nicolas Meyer | Co-Executive Producer |
| Izidore Codron | Co-Executive Producer |
| Bridget Pickering | Co-Producer |
| Luigi Musini | Co-Producer |
| A. Kitman Ho | Unit Production Manager |
| Lionel Steketee | First Assistant Director |
| Alex Oakley | Second Assistant Director |
| A. Kitman Ho | Second Unit Director |
| Tom Johnson | Sound Re-Recording Mixer |
| Doug Cooper | Sound Re-Recording Mixer |
| John Midgley | Production Sound Mixer |
| Kevin Jewison | "A" Camera Operator |
| Deon Vermeulen | "B" Camera Operator |
| Deon Vermeulen | Steadicam Operator |
| Alistair Thompson | Production Accountant |
| Elaine Burt | Production Coordinator |
| Bruce Thomas | Chief Lighting Technician |
| Charl Phyfer | Key Grip |
| Andy Kennedy | Sound Effects Editor |
| Nigel Stone | Dialogue Editor |
| Nick Lowe | ADR Editor |
| Conor Mackey | ADR Editor |
| Mike Wood | Foley Editor |
| Andie Derrick | Foley Artist |
| Peter Burgis | Foley Artist |
| Paul Carr | Foley Mixer |
| Mark Paterson | Foley Mixer |
| June Prinz | Boom Operator |
| David Sutton | Boom Operator |
| Michael Connell | Music Editor |
| Gavin Meadon | Special Effects Supervisor |
| David Mahlangu | Special Effects Coordinator |
| Jane Trower | First Assistant Accountant |
| Guy Fletcher | Sound Mixer |
