 | Reese Witherspoon als Lisa Jorgenson |
 | Paul Rudd als George |
 | Owen Wilson als Manny |
 | Jack Nicholson als Charles |
 | Kathryn Hahn als Annie |
 | Molly Price als Coach Sally |
 | Shelley Conn als Terry |
 | Tony Shalhoub als Psychiatrist |
 | Mark Linn-Baker als Ron |
 | Lenny Venito als Al |
 | Ron McLarty als George's Lawyer |
 | Domenick Lombardozzi als Bullpen Pitcher |
 | John Tormey als Doorman |
 | Teyonah Parris als Riva |
 | Dean Norris als Softball Coach |
 | Tara Subkoff als Subpoena Woman |
 | Kimberly Spak als Baseball Fan (uncredited) |
 | David A. Gregory als Matty's Teammate (as David Gregory) |
 | Donna Dundon als Annie's Mom |
| Cyrus Newitt als Annie's Dad |
 | Will Blagrove als Matty's Teammate |
 | Andrew Wilson als Matty's Teammate |
 | Yuki Matsuzaki als Tori |
 | Bill McKinney als Maitre d' |
 | Jim Bouton als Bullpen Coach |
| Ken Farnell als Bus Driver (as Kenny Farnell) |
 | Mary Gallagher als Other Female Coach |
| Aileen Zoccola als Player's Wife |
| Sachi Jonas als Player's Wife |
| Amanda Moshay als Player's Wife |
 | Lyssa Roberts als Groped Girl (as Lyssa Lee Roberts) |
| Seth Sanders als Cocky Agent |
| Elyse Braner als U.S. National Team |
| Ryann Hendricks als U.S. National Team |
| Jessi Sheldon als U.S. National Team (as Jessi Moore) |
| Amanda Freed als U.S. National Team |
| Jaime Wohlbach als U.S. National Team |
| Anjelica Selden als U.S. National Team |
| Lovieanne Jung als U.S. National Team |
| Suze Kilner als U.S. National Team |
 | Brian Distance als U.S. National Team |
| Michael Toolan-Roche als U.S. National Team |
| Caitlin Hanrahan als U.S. National Team |
| Deanna Vecchio als U.S. National Team |
| Samantha Yodowitz als U.S. National Team |
| Crystl Bustos als U.S. National Team |
| Andrea Duran als U.S. National Team |
| Jackie Dempsey als U.S. National Team |
| Tara Henry als U.S. National Team |
| Carri Martin als U.S. National Team |
| Greg Pronko als Security Guard #2 |
| Daymien Valentino als Translator |
| Jeff Ayars als Job Fair Candidate (uncredited) |
| Nate Bailey als Dr. J. Ford (uncredited) |
| Scott Barry als Driver (Precision) (uncredited) |
| Terrence Beasor als Lisa's Dad (uncredited) |
| Alexandra Begg als Baseball Player's Wife (uncredited) |
 | Jacob Bertrand als Boy (uncredited) |
 | Robert Bizik als Locksmith (uncredited) |
| Ian Bonner als Lawyer (uncredited) |
| Charlie Bonnin als Young Lisa's Dad (uncredited) |
 | Anthony Bradford als Partygoer #1 (uncredited) |
 | Rachel Breitag als Gorgeous Girl #1 (uncredited) |
| Ernest E. Brown als Restaurant Patron (uncredited) |
| Laura Bryce als Gorgeous Girl SI (uncredited) |
 | Jennifer Butler als Charles' Paralegal (uncredited) |
| Catherine Cahill als Wealthy Woman (uncredited) |
| Kimberly Lynn Campbell als U.S. National Team (uncredited) |
| Maria Cecile Callier als Spectator and Pedestrian (uncredited) |
| Mustafa Cimen als Foreign Diplomat (uncredited) |
| Sheri Cohen als Frisbee Player (uncredited) |
| Chris Conlon als Bullpen Pitcher (uncredited) |
| Moogega Cooper als College Student (uncredited) |
| Kirk Curran als College Student (uncredited) |
| Jessica Czop als Groupie (uncredited) |
| Tom Delconte als Charles' Lawyer (uncredited) |
 | Patricia DiZebba als Condo Resident (uncredited) |
| Robin Dorsey als Upscale Shopper (uncredited) |
| Bennett Dunn als Restaurant Bartender (uncredited) |
| Cindy Engle als Pedestrian (uncredited) |
| Amy Gieske als Nationals Fan (uncredited) |
| Philip Greene als Baseball Fan (uncredited) |
| Philip Greene als Baseball Fan (uncredited) |
| Doug Henderson als Tourist (uncredited) |
| Ken Holliday als Baseball Fan (uncredited) |
| Sidmar Holloman als Fan (uncredited) |
| George Kardulias als Baseball Fan in the Bleachers (uncredited) |
| Jonathan Karp als Busboy (uncredited) |
 | Basil Kershner als Player's Parent (uncredited) |
| Steven J. Klaszky als Pedestrian (uncredited) |
| Michael J. Kraycik als Cafe Patron (uncredited) |
| Atif Lanier als U.S. National Team (uncredited) |
| Traci Law als Lawyer (uncredited) |
| Alexander Lee als DC Businessman (uncredited) |
 | Michael James Levy als Waiter (uncredited) |
| Chris Luensman als Bar Patron (uncredited) |
| Quang Ly als Computer Tech (uncredited) |
| Brian M. Martin als Backpacking Student (uncredited) |
| Cindy Marie Martin als Nationals Fan (uncredited) |
| Marguerite Mastromatto als Hospital Nurse (uncredited) |
| Christian Polk McRee als Softball Player (uncredited) |
 | Patsy Meck als Charles' Maid (uncredited) |
 | John Mitchell als Aussie Baseball Fan (uncredited) |
| Mike Monroe als Bartender (uncredited) |
| Paul Monte Jr. als Drunk Teammate (uncredited) |
| Christian Monturano als Rich Baseball Player (uncredited) |
 | Noah Baron als Baseball Fan (uncredited) |
| Julie Ansell | Producer |
| James L. Brooks | Writer |
| Laurence Mark | Producer |
| James L. Brooks | Director |
| John D. Schofield | Executive Producer |
| James L. Brooks | Producer |
| Paula Weinstein | Producer |
| Richard Marks | Editor |
| Kevin Kaska | Orchestrator |
| Anthony Dunne | Art Direction |
| Janusz Kamiński | Director of Photography |
| Merideth Boswell | Set Decoration |
| Jeannine Oppewall | Production Design |
| David Blass | Art Direction |
| Tracey Wadmore-Smith | Editor |
| Francine Maisler | Casting |
| Hans Zimmer | Original Music Composer |
| Nancy Nye | Set Decoration |
| Shay Cunliffe | Costume Design |
| BJ Davis | Stunt Coordinator |
| Aaron Vexler | Stunt Double |
| Matt Leonard | Utility Stunts |
| Francine Maisler | Co-Producer |
| Richard Marks | Co-Producer |
| Amanda Moshay | Associate Producer |
| Aldric La'Auli Porter | Co-Producer |
| Richard Sakai | Executive Producer |
| Seth Sanders | Associate Producer |
| Aldric La'Auli Porter | First Assistant Director |
| Maggie Murphy | Second Assistant Director |
| Jessica Franks | Additional Second Assistant Director |
| Brett Robinson | Second Second Assistant Director |
| Alison C. Rosa | Additional Second Assistant Director |
| Denise Sirkot | Executive In Charge Of Production |
| Yvonne Yaconelli | Production Supervisor |
| John D. Schofield | Unit Production Manager |
| Carol Flaisher | Production Supervisor |
| Lydia Bensimmon | Key Hair Stylist |
| June Brickman | Key Makeup Artist |
| Ljiljana Lee Cado | Assistant Makeup Artist |
| Robin Fredriksz | Makeup Artist |
| Michael Germain | Makeup Artist |
| Daniel Howell | Hairstylist |
| Janice Innella | Hairstylist |
| Lindsay Irish-Desarno | Makeup Artist |
| Geraldine Jones | Hairstylist |
| Christina Smith | Makeup Department Head |
| Lona Vigi | Hairstylist |
| Michael White | Hair Department Head |
| Patty York | Makeup Artist |
| Joy Zapata | Hairstylist |
| Lisa Hans-Wolf | Makeup Artist |
| Sandra Linn Koepper | Makeup Artist |
| Sherri Bramlett | Hairstylist |
| Dennis Bradford | Assistant Art Director |
| Thomas E. Brown | Paint Coordinator |
| Sarah Contant | Set Designer |
| Luke A. Dean | Painter |
| Michael T. Galvin | Leadman |
| Halina Gebarowicz | Assistant Art Director |
| Edward R. Geller | Construction Grip |
| Antony Graf | Key Construction Grip |
| Jon E. Graf | Construction Foreman |
| Amy Heinz-Barnett | Set Designer |
| Lori A. Lopes | Art Department Coordinator |
| Dennis Madigan | Set Dresser |
| C.J. Maguire | Property Master |
| Paul Maiello | Construction Coordinator |
| Mark Moretti | Storyboard Artist |
| Dan Pemberton | Construction Coordinator |
| Roger Prater | Greensman |
| Rudy Reachi | Assistant Property Master |
| Michael Sabo | Property Master |
| Mark Skversky | Set Dresser |
| Scott Taft | Carpenter |
| Dave Trevino | Painter |
| Deb Adair | Additional Sound Re-Recording Mixer |
| Ulrika Akander | Dialogue Editor |
| Brian Armstrong | Foley Editor |
| Bill Burns | Assistant Sound Editor |
| Anita Cannella | Foley Artist |
| Dennis Drummond | Supervising Sound Editor |
| Kim Drummond | Dialogue Editor |
| Ann Ducommun | Assistant Sound Editor |
| Carl Fischer | Boom Operator |
| David Giammarco | Sound Re-Recording Mixer |
| Laura Graham | ADR Editor |
| Jeff Gross | Foley Mixer |
| Scott G.G. Haller | Dialogue Editor |
| Kimberly Harris | Supervising ADR Editor |
| Petur Hliddal | Sound Mixer |
| Scott A. Jennings | Sound Effects Editor |
| Amy Kane | Foley Artist |
| Rick Kline | Sound Re-Recording Mixer |
| Howard London | ADR Mixer |
| Melissa Lytle | Assistant Sound Editor |
| James Matheny | Dialogue Editor |
| Will Riley | Foley Editor |
| Michael Semanick | Sound Re-Recording Mixer |
| D. Chris Smith | Sound Effects Editor |
| Paul Vigil | Special Effects Coordinator |
| David H. Watkins | Special Effects Coordinator |
| Raoul Bolognini | Visual Effects Producer |
| Joey Bonander | Visual Effects Coordinator |
| Syd Dutton | Matte Painter |
| Rocco Passionino | Visual Effects Supervisor |
| Tristan Porter | Digital Compositor |
| Phil Adams | Stunt Coordinator |
| Mark Robert Ellis | Stunt Coordinator |
| Liam Ferguson | Stunt Driver |
| Johnny Becker | Stunt Double |
| Alex Applefeld | Video Assist Operator |
| Shawn C.H. Baron | Dolly Grip |
| Chris Beattie | Key Rigging Grip |
| George Billinger III | "B" Camera Operator |
| George Billinger III | Steadicam Operator |
| Mark Catania | Dolly Grip |
| Molly Cheshire | Lighting Technician |
| Anthony DeFrancesco | Loader |
| David Devlin | Gaffer |
| Mitch Dubin | "A" Camera Operator |
| Frank Grasso | Best Boy Grip |
| Samuel R. Harrison III | Video Assist Operator |
| Edward Hohman | Best Boy Grip |
| David James | Still Photographer |
| John Keating | Best Boy Electric |
| Jay Kemp | Rigging Gaffer |
| Jim Kwiatkowski | Key Grip |
| James 'Otis' Mayfield | Second Assistant "B" Camera |
| David Noble | Key Rigging Grip |
| David O'Brien | Second Assistant "A" Camera |
| Earl Perque | Best Boy Grip |
| Lawrence Price | Rigging Gaffer |
| Larry J. Richardson | Best Boy Electric |
| Dan Ming | First Assistant "B" Camera |
| Mark Spath | First Assistant "A" Camera |
| Diana Ulzheimer | Loader |
| Elizabeth Chodar | Casting Assistant |
| Kathy Driscoll-Mohler | Casting Associate |
| Jennifer Euston | Casting Associate |
| Diane Heery | Extras Casting |
| Dagmar Wittmer | Extras Casting |
| Chris Bustard | Extras Casting |
| Jaime Dollhopf | Set Costumer |
| Rocio Estrada Blackwell | Costumer |
| Catharine Fletcher Incaprera | Costume Supervisor |
| Mara Majorowicz | Key Costumer |
| Helen Monaghan | Costume Supervisor |
| Daniel Grant North | Key Costumer |
| Katie Saunders | Assistant Costume Designer |
| Hans Georg Struhar | Key Costumer |
| Debbie Travis | Costumer |
| Teresa Binder Westby | Costumer |
| Angeline Zeigler | Costumer |
| Sherry Gallarneau | Script Supervisor |
| David Marks | First Assistant Editor |
| John Persichetti | Digital Colorist |
| Shelly Westerman | Additional Editor |
| Abbi Jutkowitz | Assistant Editor |
| Mo Henry | Negative Cutter |
| Alex Brownley | Dailies Operator |
