 | Michelle Pfeiffer als Rosie |
 | Paul Rudd als Adam Perl |
 | Saoirse Ronan als Izzie Mensforth |
 | Stacey Dash als Brianna Minx |
 | Fred Willard als Marty |
 | Jon Lovitz als Nathan Mensforth |
 | Sarah Alexander als Jeannie |
 | Yasmin Paige als Melanie |
 | Graham Norton als Taylor |
 | David Mitchell als David - Writer |
 | O.T. Fagbenle als Sean Jamal Knight |
 | Rory Copus als Dylan |
 | Tracey Ullman als Mother Nature |
 | Steve Pemberton als Censor |
 | Henry Winkler als Self |
 | Twink Caplan als Sissy |
 | Ashley Lloyd als Zak |
 | Wallace Shawn als Izzie's Teacher |
 | Mackenzie Crook als Producer |
 | Peter Polycarpou als 2nd Producer |
 | Olivia Colman als Hairdresser |
 | Archie Panjabi als Casting Girl |
 | Ed Byrne als Delivery Boy |
 | Chike Chan als Allergy Actor |
 | Troy Gentile als Fighting Boy |
 | Sally Kellerman als Self |
 | Phil Cornwell als Cameraman |
 | Iddo Goldberg als Director |
| Noah Lee Margetts als Monty |
 | Jonathan Ryland als Prop Guy |
 | Simon Kunz als Intruder |
 | Victoria Chalaya als Nathan's Wife |
 | Doña Croll als Marty's Secretary |
 | Cassandra Bell als Pretty Waitress |
 | Sam Fusaro als Bouncer |
| Jennifer Sims als Parent 2 |
| Joe Montana als Very Large Guy |
 | Melanie Martin als Sean's Wife (uncredited) |
| Wallace Shawn als Math Teacher (uncredited) |
 | Kya Garwood als You go girl crew (uncredited) |
 | Erin Gavin als Dancer (uncredited) |
 | David Cassidy als Self (archive footage) (uncredited) |
 | Richard Nixon als Self (archive footage) (uncredited) |
 | Benito Mussolini als Self (archive footage) (uncredited) |
| Amy Heckerling | Director |
| Cerise Hallam Larkin | Producer |
| Alan Latham | Producer |
| Philippe Martinez | Producer |
| Brian Tufano | Director of Photography |
| Kate Coggins | Editor |
| Anne McCarthy | Casting |
| Jay Scully | Casting |
| Kelly Valentine Hendry | Casting Associate |
| Freddy Luis | Casting Associate |
| Wayne Morse | Casting Associate |
| Kellie Roy | Casting Associate |
| Jon Henson | Production Design |
| Patrick Rolfe | Art Direction |
| Robert Wischhusen-Hayes | Set Decoration |
| Elizabeth Wilson | Assistant Costume Designer |
| Rebecca Duncan | Costume Supervisor |
| Lisa Lovaas | Costume Supervisor |
| Yulia Gershenzon | Set Costumer |
| Phillip Howard | Set Costumer |
| Jennifer Lewicki | Art Department Coordinator |
| Barbara Olvera | Hair Department Head |
| Aileen Seaton | Hair Designer |
| Carol Hemming | Hairstylist |
| Michelle Bühler | Makeup Department Head |
| Aileen Seaton | Makeup Designer |
| Louise Constad | Makeup Artist |
| Naomi Donne | Makeup Artist |
| Claudine Strasser | Script Supervisor |
| Tom Chichester-Clark | Music Editor |
| Matthieu Clouard | Music Editor |
| Phil Hope | Music Supervisor |
| Steven Finestone | Camera Operator |
| Mike Scott | Steadicam Operator |
| Chuck Zlotnick | Still Photographer |
| Nick Wall | Still Photographer |
| Randy Paik | Additional Camera |
| Liam McGill | Gaffer |
| Caroline Hewson | Visual Effects Coordinator |
| Jola Piesakowska | Visual Effects Supervisor |
| Tim Hands | Supervising Sound Editor |
| Jessica Hurles-Laws | Second Assistant Director |
| Wayne Michaels | Stunt Coordinator |
| Gary Combs | Stunt Coordinator |
| Tracey Eddon | Stunt Coordinator |
| Chris Thompson | Line Producer |
| Hugh Spurling | Associate Producer |
| Elie Samaha | Executive Producer |
| Trish Hofmann | Line Producer |
| David Gorton | Executive Producer |
| George Edde | Co-Producer |
| Twink Caplan | Associate Producer |
| Alastair Burlingham | Executive Producer |
| Karinne Behr | Executive Producer |
| Jonathan Harvey | Second Unit Director of Photography |
| Ron Veto | Steadicam Operator |
| Dan Hubbard | Casting Director |
| Shay Cunliffe | Costume Designer |
| Michael Hedges | Original Music Composer |
| Amy Heckerling | Writer |
