 | Joaquin Phoenix als Larry "Doc" Sportello |
 | Josh Brolin als Lt. Det. Christian F. "Bigfoot" Bjornsen |
 | Owen Wilson als Coy Harlingen |
 | Katherine Waterston als Shasta Fay Hepworth |
 | Reese Witherspoon als Deputy D.A. Penny Kimball |
 | Benicio del Toro als Sauncho Smilax |
 | Jena Malone als Hope Harlingen |
 | Joanna Newsom als Sortilège |
 | Jordan Christian Hearn als Denis |
 | Hong Chau als Jade |
 | Jeannie Berlin als Aunt Reet |
 | Maya Rudolph als Petunia Leeway |
 | Michael Kenneth Williams als Tariq Khalil |
 | Martin Short als Dr. Rudy Blatnoyd, D.D.S. |
 | Sasha Pieterse als Japonica Fenway |
 | Martin Donovan als Crocker Fenway |
 | Eric Roberts als Michael Z. Wolfmann |
 | Serena Scott Thomas als Sloane Wolfmann |
 | Christopher Allen Nelson als Glenn Charlock |
 | Sam Jaeger als Agent Flatweed |
 | Timothy Simons als Agent Borderline |
 | Jillian Bell als Chlorinda |
 | Taylor Bonin als Ensenada Slim |
 | Martin Dew als Dr. Buddy Tubeside |
 | Shannon Collis als Bambi |
 | Catherine Haena Kim als News Reporter |
| Vivienne Khaledi als Amethyst Harlingen |
 | Yvette Yates Redick als Luz |
| Andrew Simpson als Riggs Warbling |
 | Joe Dioletto als Cop with Bigfoot |
 | Jack Kelly als Burke Stodger (archive footage) |
| The Growlers als The Boards |
 | Belladonna als Clancy Charlock |
| Alina Gatti als Howdy Doper's Phone Voice (voice) |
 | Elaine Tan als Xandra |
 | Wilson Bethel als LAPD Officer #1 |
 | Anders Holm als LAPD Officer #2 |
| Emmet Unverzagt als Bigfoot's Kid |
 | Erica Sullivan als Dr. Lily Hammer |
 | Eva Fisher als Dr. Threeply's Assistant #1 |
 | Jackie Michele Johnson als Dr. Threeply's Assistant #2 |
 | Katie Schwartz als Kimberly |
 | Charley Morgan als Dr. Igor |
 | Keith Jardine als Puck Beaverton |
 | Delaina Mitchell als Mrs. Chastity Bjornsen |
| Michael Cotter als Rhus Frothingham |
 | Peter McRobbie als Adrian Prussia |
| Shannon C. Sullivan als Adrian Prussia's Secretary |
 | Samantha Lemole als Golden Fang Mother |
 | Madison Leisle als Golden Fang Daughter |
| Liam Van Joosten als Golden Fang Son |
| Matt Doyle als Golden Fang Father |
 | Christian Williams als Smedley |
 | Jefferson Mays als Dr. Threeply |
 | David Prak als Buddhist Monk |
 | Amy Ferguson als Bodhi |
 | Emma Dumont als Zinnia |
| Scott Aschenbrenner als Jesus Guard (uncredited) |
 | Christina Bobrowsky als Patient (uncredited) |
| Peter Bonilla als Police Officer (uncredited) |
| Gregoer Boru als Recording Tech (uncredited) |
 | Marianne Bourg als Beach Girl (uncredited) |
| Toyia Brown als Harmony (uncredited) |
| Stu Brumbaugh als Groupie (uncredited) |
| Seth Cash als Detective (uncredited) |
 | Laura Lyon Rossi als Groupie (uncredited) |
 | Ashleigh Biller als Patient (uncredited) |
 | Elizabeth Colunga als Patient (uncredited) |
| Emma Cooper als Groupie (uncredited) |
 | Nick de Graffenreid als Patient (uncredited) |
 | Adam Dorsey als Jesus Guard (uncredited) |
 | Ken Edling als Judge (uncredited) |
| Jenna Emery als Groupie (uncredited) |
| Al Function als Biker (uncredited) |
 | Brandy Futch als Flight Attendant (uncredited) |
| Lauren Goncher als Dental Assistant (uncredited) |
| Ellen Ho als Chinese Waitress (uncredited) |
 | Jessica Huss als Speed Freak (uncredited) |
 | Raiden Integra als Patient (uncredited) |
| Dallas James als Auto Mechanic (uncredited) |
 | Christopher Karl Johnson als Mr. Robinson (uncredited) |
| Timothy Lally als Commando (uncredited) |
 | Adeana Lane als Beach Girl (uncredited) |
 | Kira Legg als Groupie (uncredited) |
| Tracy Ann Lisa als District Attorney (uncredited) |
 | Blue LoLan als Patient (uncredited) |
| Jacob Lyman als Mormon FBI Agent (uncredited) |
 | Amanda Maddox als Flight Attendant (uncredited) |
 | Emilee Madrak als Groupie (uncredited) |
 | Kirstin Masters als Dental Assistant (uncredited) |
| Zach McMahon als Police Officer (uncredited) |
 | Chelsea O'Toole als Patient (uncredited) |
| Shaun Parker als Commando (uncredited) |
| Rodney J. Richards als Adrian Prussia's Friend (uncredited) |
| Philip Roosevelt als Hippie in Commune (uncredited) |
| Osamu Saito als Japanese Waiter (uncredited) |
| Joel Shock als Police Officer (uncredited) |
 | Matthew Skomo als Detective (uncredited) |
 | Chantal Thuy als Groupie (uncredited) |
 | Diana Elizabeth Torres als Lourdes (uncredited) |
| JoAnne Sellar | Producer |
| Paul Thomas Anderson | Director |
| Paul Thomas Anderson | Producer |
| Daniel Lupi | Producer |
| Amy Wells | Set Decoration |
| Cassandra Kulukundis | Casting |
| David Crank | Production Design |
| Jonny Greenwood | Original Music Composer |
| Ruth De Jong | Art Direction |
| Mark Bridges | Costume Design |
| Leslie Jones | Editor |
| Robert Elswit | Director of Photography |
| Adam Somner | Executive Producer |
| Thomas Pynchon | Novel |
| Albert Chi | Co-Producer |
| Paul Thomas Anderson | Writer |
| Eli Bush | Co-Producer |
| Chris Scarabosio | Sound Designer |
| Linda Cohen | Music Supervisor |
| Erica Frauman | Post Production Supervisor |
| Demelza Cronin | Production Coordinator |
| John Barba | Casting Associate |
| Karen Ruth Getchell | Production Supervisor |
| Jillian Giacomini | Script Supervisor |
| Scott Rudin | Executive Producer |
| Steven Mnuchin | Executive Producer |
| Daniel Lupi | Unit Production Manager |
| Adam Somner | First Assistant Director |
| Eric Richard Lasko | Second Assistant Director |
| Michael Bauman | Chief Lighting Technician |
| Jeff Kunkle | Key Grip |
| Erik L. Brown | First Assistant Camera |
| John Pritchett | Sound Mixer |
| David M. Roberts | Boom Operator |
| Kelly Doran | Utility Sound |
| Trevor Tavares | Second Second Assistant Director |
| Conner McKinley | Art Department Coordinator |
| Anthony D. Parrillo | Set Designer |
| Colin Anderson | Steadicam Operator |
| Aaron Ali Tichenor | Second Assistant Camera |
| Matthew Mebane | Camera Loader |
| Matthew Cavaliero | Property Master |
| Wilson Webb | Still Photographer |
| Kim Richey | Assistant Property Master |
| Andy Jurgensen | First Assistant Editor |
| Cortney Lynn Kammerer | Post Production Coordinator |
| Myke Schwartz | Stunt Coordinator |
| Karen Teneyck | Graphic Designer |
| John W. Micheletos | Leadman |
| Tyler Kettenburg | Set Dresser |
| Stephen Lauritzen | Set Dresser |
| Marco López | Set Dresser |
| Michael Murray Jr. | Set Dresser |
| Michael Tolochko | Assistant Chief Lighting Technician |
| Mike Bonnaud | Rigging Gaffer |
| Brad Rea | Dolly Grip |
| Joe Chouchanian | Best Boy Grip |
| Jamie Franta | Grip |
| Nicholas Kirsten | Grip |
| John Barba | Casting Assistant |
| Larry Ring | Location Manager |
| Kelly A. Snyder | Production Accountant |
| Brandon Linville | First Assistant Accountant |
| Aaron Walrod | Payroll Accountant |
| Kristen Kopp | Assistant Costume Designer |
| Wendy M. Craig | Costume Supervisor |
| Grace Lambert Pyke | Key Costumer |
| David 'Goldy' Goldsmith | Video Assist Operator |
| Gigi Williams | Makeup Department Head |
| Susan Stepanian | Key Makeup Artist |
| Miia Kovero | Hair Department Head |
| Patricia DeHaney | Key Hair Stylist |
| Roxane Griffin | Key Hair Stylist |
| Chris Scarabosio | Supervising Sound Editor |
| Chris Scarabosio | Sound Re-Recording Mixer |
| Matthew Wood | Supervising Sound Editor |
| David Acord | Sound Re-Recording Mixer |
| Graeme Stewart | Music Editor |
| Richard Quinn | Supervising Dialogue Editor |
| Steve Slanec | Dialogue Editor |
| Brad Semenoff | Dialogue Editor |
| Luke Dunn Gielmuda | Sound Effects Editor |
| Doug Winningham | Foley Editor |
| Coya Elliott | First Assistant Sound Editor |
| Frank Rinella | Foley Supervisor |
| Andrea Gard | Foley Artist |
| Frank Rinella | Foley Artist |
| Lars Petersen | Construction Coordinator |
| Paul E. Stroh | Transportation Coordinator |
| Chris Raines | Transportation Captain |
| Robert T. Chestnut | Transportation Co-Captain |
| Robert Ziegler | Conductor |
| Dan Muscarella | Color Timer |
| Mo Henry | Negative Cutter |
| Ed Begley Jr. | Thanks |
| Tom Ajar | Projection |
| Rachel Berry | Visual Effects Producer |
| Christina Graff | Visual Effects Producer |
| Paul Graff | Visual Effects Supervisor |
| Shye Ben Tzur | Music |
| Sally Potters | Assistant Production Coordinator |
| Jack Anderson | Thanks |
| Lucille Anderson | Thanks |
| Minnie Ida Anderson | Thanks |
| Pearl Minnie Anderson | Thanks |
| Jeremy Fry | Stunts |
| Dennis Keiffer | Stunts |
| Tom McComas | Stunts |
| Benjamin Hoffman | Stunts |
| Rick Miller | Stunts |
| Kenny Richards | Stunts |
| Jim Palmer | Stunts |
| Jimmy N. Roberts | Stunts |
| Mark Aaron Wagner | Stunts |
| Monty L. Simons | Stunts |
| Eric Linden | Stunts |
