 | Kevin Costner als Jim Garrison |
 | Tommy Lee Jones als Clay Shaw / Clay Bertrand |
 | Gary Oldman als Lee Harvey Oswald |
 | Kevin Bacon als Willie O'Keefe |
 | Michael Rooker als Bill Broussard |
 | Jack Lemmon als Jack Martin |
 | Laurie Metcalf als Susie Cox |
 | Sissy Spacek als Liz Garrison |
 | Joe Pesci als David Ferrie |
 | John Candy als Dean Andrews |
 | Pruitt Taylor Vince als Lee Bowers |
 | Jay O. Sanders als Lou Ivon |
 | Walter Matthau als Senator Long |
 | Sally Kirkland als Rose Cheramie |
 | Donald Sutherland als X |
 | Ed Asner als Guy Bannister |
 | Brian Doyle-Murray als Jack Ruby |
 | Ray LePere als Abraham Zapruder |
 | Vincent D'Onofrio als Bill Newman |
| Tom Howard als Lyndon B. Johnson |
 | Lolita Davidovich als Beverly Oliver |
| Jim Garrison als Earl Warren |
 | Wayne Knight als Numa Bertel |
 | Gary Grubbs als Al Oser |
 | Beata Pozniak als Marina Oswald |
 | Tony Plana als Carlos Bringuier |
 | John William Galt als L.B.J. (voice) |
| Ron Jackson als FBI Spokesman |
 | Sean Stone als Jasper Garrison |
 | John S. Davies als Hobo #2 |
 | Tomas Milian als Leopoldo |
 | Raul Aranas als Angelo |
 | Gail Cronauer als Janet Williams |
 | Gary Carter als Bill Williams |
| James N. Harrell als Sam Holland |
 | Ellen McElduff als Jean Hill |
 | Jo Anderson als Julia Ann Mercer |
 | Marco Perella als Mercer Interrogator |
 | Edwin Neal als Mercer Interrogator |
 | Darryl Cox als FBI Agent #2 with Hill |
 | T.J. Kennedy als Hill Interrogator |
 | J.J. Johnston als Mobster with Broussard |
| R. Bruce Elliott als Bolton Ford Dealer |
| William Larsen als Will Fritz |
 | Wayne Tippit als FBI Agent - Frank |
 | Dale Dye als General Y |
 | Jerry Douglas als Board Room Man |
| Ryan MacDonald als Board Room Man |
 | Duane Grey als Board Room Man |
 | George R. Robertson als White House Man |
| Baxter Harris als White House Man |
 | John Seitz als General Lemnitzer |
 | Alex Rodine als White House Man |
| Sam Stoneburner als White House Man |
 | Bob Gunton als TV Newsman #3 |
 | John Finnegan als Judge Haggerty |
| Walter Breaux als Vernon Bundy |
| Melodee Bowman als FBI Receptionist |
 | Peter Maloney als Colonel Finck |
 | Richard Rutowski als Fence Shooter |
 | Bill Bolender als Prisoner Powell |
 | Price Carson als Tippet |
 | Gil Glasgow als Tippet Shooter |
 | Bob Orwig als Officer Poe |
| Hugh Feagin als Dr. Rose (credited in Director's Cut) |
| George Kelly als Jerry Johnson's Sidekick (credited in Director's Cut) |
| Victor Kempster als Samuel (credited in Director's Cut) |
 | John Larroquette als Jerry Johnson (credited in Director's Cut) |
 | Maria Mason als Garrison's Secretary (credited in Director's Cut) |
 | Ron Rifkin als Mr. Goldberg / Spiesel (credited in Director's Cut) |
 | Frank Whaley als Oswald Imposter (credited in Director's Cut) |
| Kevin Beard als (uncredited) |
| Jeffrey Bornstein als Hitman (uncredited) |
 | Marie Del Marco als Secretary in Window (uncredited) |
| Alan Donnes als Reporter (uncredited) |
 | Orlando Gallegos als Plaza Witness (uncredited) |
| Robert J. Groden als Courtroom Projectionist (uncredited) |
 | Chuck Kelley als Dallas County Sherriff (uncredited) |
| Codie Scott als Man in Court (uncredited) |
 | Martin Sheen als Narrator (voice) (uncredited) |
 | John F. Kennedy als Self (archive footage) |
| Anthony Ramirez als Epileptic |
| Stanley White als B Team Shooter |
 | Fidel Castro als Self (archive footage) |
 | Jacqueline Kennedy als Self (archive footage) |
 | John Connally als Self (archive footage) |
 | Richmond Hoxie als TV Reporter |
| Allison Pratt Davis als Elizabeth Garrison |
| Scott Krueger als Snapper Garrison |
 | Ngô Đình Diệm als Self - Walking with Stick (archive footage) |
| Oliver Stone | Screenplay |
| Zachary Sklar | Screenplay |
| A. Kitman Ho | Producer |
| Oliver Stone | Producer |
| Arnon Milchan | Executive Producer |
| Clayton Townsend | Producer |
| John Williams | Original Music Composer |
| Robert Richardson | Director of Photography |
| Joe Hutshing | Editor |
| Pietro Scalia | Editor |
| Risa Bramon Garcia | Casting |
| Heidi Levitt | Casting |
| Billy Hopkins | Casting |
| Victor Kempster | Production Design |
| Derek R. Hill | Art Direction |
| Alan Tomkins | Art Direction |
| Crispian Sallis | Set Decoration |
| Marlene Stewart | Costume Design |
| Randy E. Moore | Special Effects Coordinator |
| Bob Shelley | Special Effects |
| Miller Drake | Visual Effects |
| Webster Whinery | Stunt Coordinator |
| Sidney Ray Baldwin | Still Photographer |
| Susan Malerstein | Script Supervisor |
| Kenneth Wannberg | Music Editor |
| J. Michael Muro | Steadicam Operator |
| John Shoemaker | Rigging Gaffer |
| Michael D. Wilhoit | Supervising Sound Editor |
| Wylie Stateman | Supervising Sound Editor |
| Scott Martin Gershin | Sound Effects Editor |
| Mark Lanza | Sound Effects Editor |
| Jay B. Richardson | Sound Effects Editor |
| Martha Marek Beresford | Hairstylist |
| Bonnie Clevering | Hairstylist |
| Kelvin R. Trahan | Hairstylist |
| Ron Scott | Hairstylist |
| Wade Daily | Makeup Artist |
| Elaine Thomas | Makeup Artist |
| Cassandra Scott | Makeup Artist |
| Elle Elliott | Key Hair Stylist |
| Deborah Mills-Whitlock | Hairstylist |
| Craig Berkeley | Makeup Artist |
| Ron Berkeley | Makeup Artist |
| Kevin Beard | Utility Stunts |
| Mark Burchard | Costume Design |
| Michael F. Burke | Electrician |
| William H. Brown | Post Production Supervisor |
| Margaret Johnson | Special Effects Supervisor |
| Warren Keillor | Special Effects |
| Kate Crossley | Assistant Editor |
| David Orr | Color Timer |
| Christopher Assells | Dialogue Editor |
| David A. Arnold | Dialogue Editor |
| Willy Allen | Dialogue Editor |
| Richard Dwan Jr. | Dialogue Editor |
| Alison Fisher | Dialogue Editor |
| Mark Gordon | Dialogue Editor |
| Bob Newlan | Dialogue Editor |
| Dan M. Rich | Dialogue Editor |
| Hugo Weng | Dialogue Editor |
| Mary Andrews | ADR Editor |
| Avram D. Gold | ADR Supervisor |
| Jerelyn J. Harding | ADR Editor |
| Philip C. Pfeiffer | Camera Operator |
| J. Grey Smith | Property Master |
| Joseph P. Reidy | First Assistant Director |
| Joseph P. Reidy | Associate Producer |
| Joe Burns | Second Assistant Director |
| Jerry G. Callaway | Additional Camera |
| J. Michael McClary | Additional Camera |
| Tana Bishop | Art Department Coordinator |
| Margery Z. Gabrielson | Assistant Art Director |
| Rodney Armanino | Construction Coordinator |
| Jack Kostelnik | Construction Foreman |
| Dennis Collins | Painter |
| Barby Kirk | Props |
| Mary Saisselin | Set Designer |
| Mandy Brou | Set Dresser |
| Bill Darrow | Standby Painter |
| Mark A. Hatley | Grip |
| Chris Centrella | Key Grip |
| Lisa Lovaas | Assistant Costume Designer |
| Dan Bronson | Costume Supervisor |
| Ron Berkeley | Key Makeup Artist |
| Derek Abernathy | Carpenter |
| Kayla Chaillot | Craft Service |
| Brooks Baldwin | Dialect Coach |
| Patrick Hogan | Driver |
| Budd Carr | Executive Music Producer |
| Tutt Esquerre | Picture Car Coordinator |
| Romy Stevenson | Production Intern |
| John A. Kelly | Scenic Artist |
| Charlie French | Set Medic |
| Daniel Burns | Set Production Assistant |
| Mark Thomason | Stand In |
| Jamie Dierlam | Stunts |
| William B. Borges | Transportation Captain |
| Alvin L. Milliken Sr. | Transportation Coordinator |
| Roger Armstrong | Unit Publicist |
| F. Paul Benz | First Assistant Editor |
| Juel Bestrop | Casting Associate |
| Patricia Anne Doherty | Location Manager |
| Leeann Stonebreaker | Production Coordinator |
| Clayton Townsend | Production Manager |
| Dianne E. Collins | Publicist |
| Thomas Hayslip | Research Assistant |
| Robert Batha | Assistant Sound Editor |
| T.J. O'Mara | Boom Operator |
| Sandy Berman | Foley Editor |
| Tim Morrison | Musician |
| John Neufeld | Orchestrator |
| Tod A. Maitland | Production Sound Mixer |
| Joseph Holsen | Sound Editor |
| Joseph A. Brennan | Sound Engineer |
| Gregg Landaker | Sound Re-Recording Mixer |
| Mark 'Frito' Long | Sound Recordist |
| Fran Allgood | Costumer |
| Deborah Lupard | Second Second Assistant Director |
| Philip C. Pfeiffer | Second Unit Director |
| Carl Catanese | Set Buyer |
| Lance Cheatham | Swing |
| Charleen Richards-Steeves | ADR Mixer |
| Judson Leach | Apprentice Sound Editor |
| Dan O'Connell | Foley Artist |
| Greg Orloff | Foley Mixer |
| David M. Roberts | Utility Sound |
| Eddie Perez | Stunt Driver |
| Michael Off | Assistant Camera |
| Jeff Kluttz | Best Boy Grip |
| Richard Sobin | Camera Loader |
| Kenny Davis | Dolly Grip |
| Faires A. Sekiya | Second Assistant Camera |
| Ann Goulder | Casting Assistant |
| Julie Monroe | Associate Editor |
| Donah Bassett | Negative Cutter |
| Gary Huckabay | Assistant Location Manager |
| Sandra Dawes | Location Casting |
| Frank Scheidbach | Assistant Chief Lighting Technician |
| Margaret Lancaster | Assistant Production Coordinator |
| Reinhart Peschke | Chief Lighting Technician |
| Jonathan M. Abrams | Production Assistant |
| Liam Finn | Production Secretary |
| Numa V. Bertel Jr. | Technical Advisor |
| Paul Etheredge | Art Department Assistant |
| Oliver Stone | Director |
| Jim Garrison | Book |
| Jim Marrs | Book |
| Michael Johnson | Production Assistant |
| Bill Daly | Sound Mixer |
| Andria Litto | Wardrobe Assistant |
| John Stockwell | Technical Advisor |
| Donald Carlson | First Assistant Camera |
