 | Keanu Reeves als Johnny Mnemonic |
 | Dina Meyer als Jane |
 | Takeshi Kitano als Takahashi |
 | Ice-T als J-Bone |
 | Dolph Lundgren als Street Preacher |
 | Denis Akiyama als Shinji |
 | Henry Rollins als Spider |
 | Barbara Sukowa als Anna Kalmann |
 | Udo Kier als Ralfi |
 | Tracy Tweed als Pretty |
 | Falconer Abraham als Yomamma |
 | Don Francks als Hooky |
 | Diego Chambers als Henson |
 | Sherry Miller als Takahashi's Secretary |
 | Arthur Eng als Viet |
 | Von Flores als Viet |
| Victoria Tengelis als Pharmakom Receptionist |
 | Warren Sulatycky als Yakuza Operator |
| Celina Wu als Mikiyo |
 | Jamie Elman als Toad |
 | Simon Sinn als Man in Hotel Lobby |
| Caitlin Carmody als Twin in Hotel Lobby |
| Erin Carmody als Twin in Hotel Lobby |
 | Douglas O'Keeffe als Pharmakom Security Officer |
| Marlow Vella als Lotek Kid |
| Howard Szafer als Strike |
| Paul Brogren als Stump |
| Arthi Sambasivan als Nurse |
 | Michael A. Miranda als Stick |
| Coyote Shivers als Buddy |
 | Lynne Adams als Yakuza with Rocket Launcher |
 | Michael Shearer als Yakuza Partner |
| Susan Tsagkaris als Opera Singer |
 | Christopher Comrie als Beijing Riot Newscaster |
| Robin Crosby als Girl in Hotel Room |
 | Glenn Bang als Bandleader (uncredited) |
| Natalie Gray als Tall Chinese Man (uncredited) |
| Gene Mack als Laslo |
| Robert Longo | Director |
| François Protat | Director of Photography |
| Ronald Sanders | Editor |
| Staffan Ahrenberg | Executive Producer |
| Victoria Hamburg | Executive Producer |
| Robert Lantos | Executive Producer |
| Don Carmody | Producer |
| Brad Fiedel | Original Music Composer |
| Tig Fong | Stunts |
| Mychael Danna | Original Music Composer |
| Nilo Rodis-Jamero | Production Design |
| Dennis Davenport | Art Direction |
| Enrico Campana | Set Decoration |
| Olga Dimitrovová | Costume Design |
| Linda Gill | Key Makeup Artist |
| Marilyn Terry | Assistant Makeup Artist |
| Fred C. Blau Jr. | Tattoo Designer |
| Ian McDougall | Production Manager |
| Jean Desormeaux | Supervising Producer |
| Bernard Vincent | Unit Production Manager |
| Pierre Laberge | Unit Production Manager |
| Michael Jewison | Post Production Supervisor |
| Gregor Hutchison | Post Production Supervisor |
| Mike Franklin | Set Dresser |
| Kim Karon | Assistant Art Director |
| Don McQueen | Assistant Set Decoration |
| Michèle Nolet | Set Decoration |
| Andrew M. Stearn | First Assistant Art Direction |
| Ian Hall | First Assistant Art Direction |
| Richard Tassé | Set Decoration |
| Dan Wladyka | Assistant Set Decoration |
| Jay Boekelheide | Sound Effects Editor |
| Patrick Dodd | Supervising Sound Editor |
| Douglas Ganton | Sound Mixer |
| Mark Lanza | Sound Effects Editor |
| Michael Mennies | Sound Effects Editor |
| Douglas Murray | Sound Designer |
| Jonathan Null | Sound Effects Editor |
| Scott Purdy | Sound Re-Recording Mixer |
| Leslie Shatz | Sound Re-Recording Mixer |
| Don White | Sound Re-Recording Mixer |
| Mark Jan Wlodarkiewicz | Sound Effects Editor |
| Bill Birrell | Visual Effects Producer |
| Anthony Ceccomancini | Visual Effects Coordinator |
| Cat Chapman | Visual Effects Coordinator |
| Ryan Berg | Visual Effects Coordinator |
| Leslie Huntley | Visual Effects Producer |
| George Merkert | Visual Effects Producer |
| Gene Warren Jr. | Visual Effects Supervisor |
| David Worman | Animation |
| Artie Romero | Animation |
| Linda Gill | Makeup Artist |
| William Gibson | Short Story |
| William Gibson | Screenplay |
| Alison Reid | Stunts |
| Shelley Cook | Stunts |
