 | Dwayne Johnson als Hank Parsons |
 | Josh Hutcherson als Sean Anderson |
 | Vanessa Hudgens als Kailani Laguatan |
 | Luis Guzmán als Gabato Laguatan |
 | Michael Caine als Alexander Anderson |
 | Kristin Davis als Elizabeth Parsons |
 | Anna Colwell als Jessica |
 | Stephen Caudill als Cop |
 | Branscombe Richmond als Tour Guide |
 | Walter Bankson als Hockey Player |
 | Cody Easterbrook als Palauan (uncredited) |
| Paul Leo Klink als Nautilus Passenger (uncredited) |
| Michael Bostick | Executive Producer |
| Evan Turner | Executive Producer |
| Mark Gunn | Screenplay |
| Brad Peyton | Director |
| Brian Gunn | Story |
| Charlotte Huggins | Producer |
| Mark Gunn | Story |
| Beau Flynn | Producer |
| Tripp Vinson | Producer |
| Brian Gunn | Screenplay |
| Larry White | Animation |
| Anthony Rizzo | Animation |
| James Baker | Visual Effects |
| Rick Avery | Pilot |
| Anna Rane | Script Supervisor |
| Mike Repeta | Camera Operator |
| Ron Phillips | Still Photographer |
| Andrew Lockington | Original Music Composer |
| Lisa Mae Fincannon | Casting |
| Andrew H. Leung | Conceptual Illustrator |
| Chad S. Frey | Set Designer |
| Peter Chesney | Special Effects Supervisor |
| Scott Anderson | Visual Effects Editor |
| Stephen Lotwis | Supervising Music Editor |
| Chun Ho Ray Leung | Modeling |
| Boyd Shermis | Visual Effects Supervisor |
| Sandra Collier | Key Costumer |
| Joy Zapata | Hair Department Head |
| Daryl Sawchuk | Animation Supervisor |
| Alex Daniels | Stunt Coordinator |
| John Casey | Costume Supervisor |
| Randy Thom | Sound Designer |
| Terri Watanabe | Visual Effects Coordinator |
| Gregory W. Smith | Camera Operator |
| Tarra D. Day | Makeup Department Head |
| Colette D. Dahanne | Foley Editor |
| Leona Naidoo | Visual Effects Editor |
| Julie Orosz | Visual Effects Producer |
| Andrea von Foerster | Music Supervisor |
| David Tattersall | Director of Photography |
| Gian Ganziano | Visual Effects Editor |
| Nick Pill | Visual Effects Supervisor |
| James Greig | Visual Effects Coordinator |
| Randy Starr | Visual Effects Producer |
| Bill Boes | Production Design |
| Adolfo Castanon | Greensman |
| Dean Wolcott | Set Designer |
| Leff Lefferts | Sound Effects Editor |
| Gary A. Krakoff | Construction Coordinator |
| Jenne Lee | Art Department Coordinator |
| Lindsey Suggs | Art Department Coordinator |
| Gwendolyn Yates Whittle | ADR Supervisor |
| John Bankson | Property Master |
| Darrell Tachibana | Greensman |
| Josh Gold | Sound Effects Editor |
| Steve Cypreos | Modeling |
| Suchitra Keshri | Modeling |
| Greg Papalia | Set Designer |
| Isaia Robins | Greensman |
| James Van Houten | Sculptor |
| Charles W. Kaeo | Key Costumer |
| David Metzner | Music Editor |
| Chuck Potter | Set Decoration |
| John Eaves | Conceptual Illustrator |
| Craig Fincannon | Casting |
| Bruce Robert Hill | Art Direction |
| John Hockridge | First Assistant Director |
| Kip Bartlett | Set Dresser |
| David Rennie | Editor |
| Gary Fettis | Set Decoration |
| Denise Wingate | Costume Design |
| Alex McCarroll | Set Designer |
| Cory Ching | Set Costumer |
| Miles Teves | Conceptual Illustrator |
| Al Nelson | Supervising Sound Editor |
| Whitney Hagan | Visual Effects Coordinator |
| Hyun Bo Park | Modeling |
| Trevor Wyatt | Visual Effects Coordinator |
| Cameron Doyle | Key Costumer |
| Christie Kwan | Production Coordinator |
| Vacheh Shahmoradian | Other |
| Boyd Shermis | Second Unit Director |
| Marilyn McCoppen | Dialogue Editor |
| Douglas Murray | Dialogue Editor |
| Stephanie Meyerink | Visual Effects Coordinator |
| Tanoai Reed | Stunt Double |
| Tim Jarvis | Stunts |
| Jennifer Brusciano | Stunt Double |
| Ralf Koch | Stunt Double |
| Craig H. Davidson | Stunts |
| Erik Parzwardek | Set Dresser |
| Benjamin Patterson | Set Dresser |
| Michael Anthony Jackson | Conceptual Illustrator |
| Richard Outten | Story |
| Daren Dochterman | Conceptual Illustrator |
| Richard Brener | Executive Producer |
| Clay Cullen | Stunts |
| Hiroshi Mori | Visual Effects |
