 | Dwayne Johnson als Frank Wolff |
 | Emily Blunt als Dr. Lily Houghton |
 | Edgar Ramírez als Lope de Aguirre |
 | Jack Whitehall als McGregor Houghton |
 | Jesse Plemons als Prince Joachim |
 | Paul Giamatti als Nilo |
 | Veronica Falcón als Trader Sam |
 | Dani Rovira als Sancho |
 | Quim Gutiérrez als Melchor |
 | Dan Dargan Carter als Gonzalo |
 | Andy Nyman als Sir James Hobbs-Coddington |
 | Raphael Alejandro als Zaqueu |
 | Simone Lockhart als Anna |
 | Pedro Lopez als Chief |
 | Sulem Calderon als Quila |
| Sebastian Blunt als Society Guard |
 | Mark Ashworth als Society Member 1 |
 | Allan Poppleton als Society Worker |
| Caroline Paige als Kid Tourist |
 | James Quattrochi als Italian Tourist |
 | Stephen Dunlevy als Middlepart |
| Philipp Maximilian als Axel |
 | Romualdo Castillo als Animal Vendor |
| Pedro Haro als Bird Vendor |
| Christina Souza als Barmaid |
 | Michael H. Cole als Bus Conductor |
 | Hector Banos als Puka Michuna Warrior |
 | Peter Luis Zimmerman als Puka Michuna Warrior |
 | Travis Gomez als Puka Michuna Warrior |
 | David Lengel als Boat Tourist |
 | Justin Randell Brooke als Boat Tourist |
| Piper Collins als Boat Tourist |
 | Keith Arthur Bolden als Boat Tourist |
 | Marcus Young als Goon (uncredited) |
| Jaume Collet-Serra | Director |
| Flavio Martínez Labiano | Director of Photography |
| Jean-Vincent Puzos | Production Design |
| Paco Delgado | Costume Design |
| John Davis | Producer |
| John Fox | Producer |
| Dany Garcia | Producer |
| Hiram Garcia | Producer |
| Douglas C. Merrifield | Executive Producer |
| Stacy Horn | Costume Supervisor |
| Joe Howes | Visual Effects |
| Tim McGovern | Digital Effects Supervisor |
| James Newton Howard | Original Music Composer |
| Joel Negron | Editor |
| Scott Sheldon | Executive Producer |
| Beau Flynn | Producer |
| Dwayne Johnson | Producer |
| John Norville | Screenstory |
| Josh Goldstein | Screenstory |
| John Requa | Screenstory |
| Michael Green | Screenplay |
| Glenn Ficarra | Screenplay |
| John Requa | Screenplay |
| Chris Hansen | Art Direction |
| Gregory S. Hooper | Art Direction |
| David Lazan | Supervising Art Director |
| Leslie McDonald | Art Direction |
| Drew Monahan | Art Direction |
| Nic Pallace | Art Direction |
| Stella Vaccaro | Art Direction |
| Thomas P. Wilkins | Art Direction |
| Dean Wolcott | Art Direction |
| Larry Dias | Set Decoration |
| Erik Aadahl | Sound Designer |
| Erik Aadahl | Supervising Sound Editor |
| Ignacio Arrojo | ADR Recordist |
| Ron Bartlett | Sound Re-Recording Mixer |
| Ian Bender | Boom Operator |
| Hunter Berk | ADR Mixer |
| Malte Bieler | Sound Editor |
| Matt Cavanaugh | Sound Effects Editor |
| Kevin Cerchiai | Boom Operator |
| Jack Cucci | Foley Mixer |
| Joel Erickson | ADR Supervisor |
| Goeun Lee Everett | Sound Effects Editor |
| Lee Gilmore | Sound Effects Editor |
| Robert Jackson | Dialogue Editor |
| Brandon Jones | Sound Designer |
| John Marquis | Sound Designer |
| Victor Mercader | Sound Editor |
| Dan O'Connell | Foley Artist |
| Jason Oliver | ADR Mixer |
| Ralph Osborn | Dialogue Editor |
| Willard Overstreet | Foley Editor |
| Aaron Southerland | ADR Mixer |
| Greg ten Bosch | Sound Effects Editor |
| Ethan van der Ryn | Supervising Sound Editor |
| Ethan van der Ryn | Sound Designer |
| Stuart Welch | ADR Recordist |
| Jim Berney | Visual Effects Supervisor |
| Gaia Bussolati | Visual Effects Supervisor |
| Christopher Downs | Visual Effects Supervisor |
| John Knoll | Visual Effects Supervisor |
| Luke Millar | Visual Effects Supervisor |
| Jake Morrison | Visual Effects Supervisor |
| Viktor Müller | Visual Effects Supervisor |
| Stephane Paris | Visual Effects Supervisor |
| Jordann Aguon | Makeup Artist |
| Laura Aguon | Makeup Artist |
| Ozzy Alvarez | Makeup Artist |
| Merc Arceneaux | Makeup Artist |
| Rachel Bongard | Makeup Artist |
| Natalie Bruce | Makeup Artist |
| Chris Diamantides | Makeup Artist |
| Addison Foreman | Makeup Artist |
| André Freitas | Makeup Artist |
| Derek Garcia | Makeup Artist |
| Melody Levy | Makeup Artist |
| Devin Shayla Morales | Makeup Artist |
| Karen Iboshi Preiser | Makeup Artist |
| Mark James Ross | Makeup Artist |
| Aida Scuffle | Makeup Artist |
| Matt Sprunger | Makeup Artist |
| Jordan Venetis | Makeup Artist |
| Michael Furniss | Visual Effects |
| Kay Hoddy | Rotoscoping Artist |
| Nicole Vela-Bailey | Stunts |
| Erika Takacs | Stunts |
| Lauren Shaw | Stunt Double |
| Lauren Shaw | Stunt Driver |
| Lauren Shaw | Utility Stunts |
| Maya Santandrea | Stunts |
| Maya Santandrea | Utility Stunts |
| Alice Rietveld | Stunt Double |
| Suzanne Reed | Stunts |
| Allan Poppleton | Stunt Coordinator |
| Zoey Chang | Stunts |
| Stacey Carino | Stunts |
| Bonnie Campanella | Stunts |
| Hannah Betts | Stunt Double |
| Hannah Betts | Stunts |
| Hannah Betts | Utility Stunts |
| Kelly Bellini | Stunts |
| Adrienne Ballenger | Stunt Double |
| Adrienne Ballenger | Stunts |
| Mary Vernieu | Casting Director |
| Marisol Roncali | Casting Director |
| Douglas C. Merrifield | Unit Production Manager |
| David H. Venghaus Jr. | First Assistant Director |
| Eric Richard Lasko | Second Assistant Director |
| Marla Neto Henshaw | Visual Effects Producer |
| Amber Kirsch | Visual Effects Producer |
| Larry J. Franco | Consulting Producer |
| Petra Holtorf | Co-Producer |
| Lacey Darlene Paulson | Associate Producer |
| David H. Venghaus Jr. | Associate Producer |
| Jeanette Surga | Supervising Music Editor |
| Mare McIntosh | Visual Effects Production Manager |
| Sarah Stauffer | Visual Effects Coordinator |
| David Gullman | Visual Effects Coordinator |
| Peter Calvillo | Visual Effects Coordinator |
| Robert Mazaraki | Production Supervisor |
| Margaret Hungerford | Assistant Set Decoration |
| Nathan Krochmal | Assistant Art Director |
| Kristen Nowotarski | Assistant Art Director |
| Joel Harlow | Makeup Department Head |
| Adruitha Lee | Hair Department Head |
| Vanessa Davis | Key Hair Stylist |
| Kimberly Felix | Key Makeup Artist |
| Anna Rane | Script Supervisor |
| Michael B. Koff | Sound Mixer |
| J.D. Schwalm | Special Effects Supervisor |
| Eric Cook | Special Effects Coordinator |
| Marc Zakalik | Production Coordinator |
| Greg Tresan | Animal Wrangler |
| Carol Tresan | Animal Wrangler |
| Jim Weidman | Music Editor |
| David Olson | Music Editor |
| Paul Ramsden | Animation Supervisor |
| David Conley | Executive Visual Effects Producer |
| Andy Taylor | Visual Effects Producer |
| Reetu Aggarwal | 3D Artist |
| Alexander Witt | Second Unit Director |
| John C. Meier | Stunts |
| Tanoai Reed | Stunt Double |
| Mike Rufino | Stunts |
| Shawn Kautz | Stunts |
| Brian L. Keaulana | Stunts |
| Thomas Robinson Harper | Stunts |
| Kris A. Jeffrey | Stunts |
| Darin Fujimori | Stunts |
| John Gilbert | Utility Stunts |
| Kent De Mond | Stunts |
| Nick Epper | Stunts |
| Sala Baker | Stunts |
| Isaac Hughes | Stunts |
| Anthony N. | Stunts |
| Dario Perez | Stunts |
| Nikolas Pelekai | Stunts |
| Gary Price | Stunts |
| Remington Steele | Stunts |
| George Quinones | Stunts |
| Nick Stanner | Stunts |
| Steve Upton | Utility Stunts |
| Robert Tinsley | Stunts |
| Jason A. Triplett | Stunts |
| Nico Woulard | Stunts |
| Marcus Young | Stunts |
| Thom Williams | Stunts |
| Tony Vittorioso | Stunts |
| Tyler Witte | Stunts |
| Riley Flanagan | Key Set Production Assistant |
| Matt Leonard | Stunts |
| Kevin Houlihan | Set Designer |
