 | Benjamin Bratt als Superman / Hernan Guerra (voice) |
 | Michael C. Hall als Batman / Kirk Langstrom (voice) |
 | Tamara Taylor als Wonder Woman / Bekka (voice) |
 | Jason Isaacs als Lex Luthor (voice) |
 | C. Thomas Howell als Dr. Will Magnus (voice) |
 | Paget Brewster als Lois Lane (voice) |
 | Kari Wahlgren als Karen Beecher / Livewire (voice) |
 | Grey DeLisle als Tina / Platinum (voice) |
 | Larry Cedar als Pete Ross (voice) |
 | Eric Bauza als Ryan Choi / Stephen Shin (voice) |
 | Penny Johnson Jerald als President Waller (voice) |
 | Dee Bradley Baker als Ray Palmer / Tin (voice) |
 | Richard Chamberlain als Highfather (voice) |
 | Trevor Devall als Emil Hamilton (voice) |
 | Dan Gilvezan als Pat Dugan (voice) |
 | Daniel Hagen als Dr. Sivana (voice) |
 | Josh Keaton als Orion (voice) |
 | Arif S. Kinchen als Michael Holt / Bronze Tiger (voice) |
 | Yuri Lowenthal als Jor-El / Jimmy Olsen (voice) |
 | Carl Lumbly als Silas Stone (voice) |
 | Jim Meskimen als Victor Fries (voice) |
 | Taylor Parks als Victor Stone (voice) |
 | Khary Payton als John Henry Irons / Granny Goodness / Mugger (voice) |
 | Tahmoh Penikett als Steve Trevor (voice) |
 | Andrea Romano als Jean Palmer (voice) |
 | André Sogliuzzo als Cop / Mr. Guerra (voice) |
 | Bruce Thomas als General Zod / Darkseid (voice) |
 | Lauren Tom als Lara Lor-Van (voice) |
 | Marcelo Tubert als Tough Guy (voice) |
 | Bruce Timm als Blockbuster (voice) (uncredited) |
| Sam Liu | Director |
| Bruce Timm | Executive Producer |
| Alan Burnett | Writer |
| Jay Oliva | Storyboard |
| Andrea Romano | Casting |
| Christopher D. Lozinski | Editor |
| Jose Delbo | Characters |
| Frederik Wiedmann | Original Music Composer |
| Alan Burnett | Story |
| Bruce Timm | Story |
| Alan Burnett | Screenplay |
| Bob Kane | Characters |
| William Moulton Marston | Characters |
| Jerry Siegel | Characters |
| Joe Shuster | Characters |
| John Ostrander | Characters |
| Marv Wolfman | Characters |
| Jerry Ordway | Characters |
| Louise Simonson | Characters |
| Jon Bogdanove | Characters |
| Bob Rozakis | Characters |
| Neal Adams | Characters |
| Jack Kirby | Characters |
| Gardner Fox | Characters |
| George Pérez | Characters |
| Alan Burnett | Co-Producer |
| Amy McKenna | Line Producer |
| Benjamin Melniker | Co-Executive Producer |
| Sam Register | Executive Producer |
| Michael Uslan | Co-Executive Producer |
| Matthew Mahoney | Assistant Production Manager |
| Sunisa Petchpoo | Production Manager |
| Jake Castorena | Storyboard Artist |
| Tim Divar | Storyboard Artist |
| Hayley Foster | Storyboard |
| Gabriel Thorburn | Assistant Editor |
