 | Hideaki Anno als Jiro Horikoshi (voice) |
 | Hidetoshi Nishijima als Honjô (voice) |
 | Miori Takimoto als Naoko Satomi (voice) |
 | Masahiko Nishimura als Kurokawa (voice) |
 | Stephen Alpert als Castorp (voice) |
 | Mansai Nomura als Giovanni Battista (voice) |
 | Jun Kunimura als Hattori (voice) |
 | Mirai Shida als Kayo Horikoshi (voice) |
 | Shinobu Otake als Mrs. Kurokawa (voice) |
 | Morio Kazama als Satomi (voice) |
 | Keiko Takeshita als Jirô's mother (voice) |
| Sascha als German Security Guard / Flight Engineer (voice) |
| Kaichi Kaburagi als Young Jiro Horikoshi (voice) |
 | Maki Shinta als Young Kayo Horikoshi (voice) |
| Hayao Miyazaki | Screenplay |
| Tatsuo Hori | Novel |
| Hayao Miyazaki | Director |
| Naoya Fujimaki | Producer |
| Ryoichi Fukuyama | Producer |
| Toshio Suzuki | Producer |
| Koji Hoshino | Executive Producer |
| Seiji Okuda | Producer |
| Joe Hisaishi | Original Music Composer |
| Hideki Hamasu | Key Animation |
| Michiyo Yasuda | Color Designer |
| Atsushi Okui | Director of Photography |
| Yoji Takeshige | Art Direction |
| Takeshi Seyama | Editor |
| Atsuko Tanaka | Key Animation |
| Eiji Yamamori | Key Animation |
| Taichi Furumata | Key Animation |
| Atsushi Tamura | Key Animation |
| Yoshimi Itazu | Key Animation |
| Kazuki Hoshino | Key Animation |
| Kitarou Kousaka | Character Designer |
| Kitarou Kousaka | Animation Director |
| Katsuya Kondo | Key Animation |
| Takeshi Inamura | Key Animation |
| Hiroomi Yamakawa | Key Animation |
| Akihiko Yamashita | Key Animation |
| Fumie Imai | Key Animation |
| Sachiko Sugino | Key Animation |
| Shinji Otsuka | Key Animation |
| Hiroko Minowa | Key Animation |
| Masaaki Endou | Key Animation |
| Takeshi Honda | Key Animation |
| Michiyo Suzuki | Key Animation |
| Atsuko Otani | Key Animation |
| Hiroyuki Aoyama | Key Animation |
| Shinya Ohira | Key Animation |
| Tsutomu Awata | Key Animation |
| Kiyotaka Oshiyama | Key Animation |
| Kazuhide Tomonaga | Key Animation |
| Akiyo Okuda | Key Animation |
| Tomoko Miura | Key Animation |
| Shunsuke Hirota | Key Animation |
| Shougo Furuya | Key Animation |
| Hideaki Yoshio | Key Animation |
| Makiko Futaki | Key Animation |
| Masafumi Yokota | Key Animation |
| Hiromasa Yonebayashi | Key Animation |
| Kazuyoshi Onoda | Key Animation |
| Kenichi Yamada | Key Animation |
| Megumi Kagawa | Key Animation |
| Eiko Matsushima | Painter |
| Jiro Horikoshi | Book |
| Hayao Miyazaki | Comic Book |
| Aya Suzuki | 2D Artist |
| Aya Suzuki | Key Animation |
